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Protein Overview: PLF4_RAT

General Information:
Name(s) found: PLF4_RAT [Swiss-Prot]
Description(s) found:
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  • pir||A26774 platelet factor 4 precursor - rat [NCBI NR]
  • gi|56090531|ref|NP_001007730.1| platelet factor 4 [Rattus norvegicus] [NCBI NR]
  • ref|XP_341193.1| similar to Platelet factor 4 precursor (PF-4) (CXCL4) [Rattus norvegicus] [NCBI NR]
  • gi|206091|gb|AAA41832.1| platelet factor 4 precursor [NCBI NR]
  • gi|149033771|gb|EDL88567.1| chemokine (C-X-C motif) ligand 4, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|130305|sp|P06765.1|PLF4_RAT RecName: Full=Platelet factor 4; Short=PF-4; AltName: Full=C-X-C motif chemokine 4; Flags: Precursor [NCBI NR]
  • Platelet factor 4 OS=Rattus norvegicus GN=Pf4 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):None Platelet factor 4 precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • similar to Platelet factor 4 precursor (PF-4) (CXCL4) [HMR_022704-rand.fasta]
  • similar to Platelet factor 4 precursor (PF-4) (CXCL4) [Rattus norvegicus]gi|130305|sp|P06765|PLF4_RAT Platelet factor 4 precursor (PF-4) (CXCL4)gi|92621|pir||A26774 platelet factor 4 precursor - ratgi|206091|gb|AAA41832.1| platelet factor 4 precursor [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Platelet factor 4 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • platelet factor 4 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Platelet factor 4 precursor (PF-4) (C-X-C motif chemokine 4) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • chemokine (C-X-C motif) ligand 4, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • platelet factor 4 precursor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 PLATELET FACTOR 4 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Platelet factor 4 precursor (PF-4) (CXCL4) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Pf4 Platelet factor 4 [rat-ipi-250309-contam.fasta]
  • Platelet factor 4 OS=Rattus norvegicus GN=Pf4 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 105 amino acids

    Gene Ontology:
    Cellular Component: platelet alpha granule lumen [UNKNOWN]
    extracellular space [IEA]
    platelet alpha granule [IDA]
    vesicle [IDA]
    protein complex [IDA]
    extracellular region [UNKNOWN][IEA]
    Biological Process: negative regulation of angiogenesis [UNKNOWN][ISS]
    protein complex assembly [IPI]
    negative regulation of cytolysis [UNKNOWN]
    negative regulation of MHC class II biosynthetic process [UNKNOWN]
    negative regulation of megakaryocyte differentiation [UNKNOWN][ISS]
    chemotaxis [IEA]
    immune response [IDA]
    positive regulation of macrophage differentiation [UNKNOWN]
    positive regulation of gene expression [UNKNOWN]
    cytokine-mediated signaling pathway [UNKNOWN][ISS]
    negative regulation of apoptosis [UNKNOWN]
    positive regulation of tumor necrosis factor production [UNKNOWN]
    positive regulation of macrophage derived foam cell differentiation [UNKNOWN]
    leukocyte chemotaxis [UNKNOWN][ISS]
    platelet activation [UNKNOWN][ISS]
    Molecular Function: heparin binding [UNKNOWN][ISS]
    chemokine activity [IEA]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAAAVFRGL RPSPELLLLG LLLLPAVVAV TRASPEESDG DLSCVCVKTS SSRIHLKRIT  60
   61 SLEVIKAGPH CAVPQLIATL KNGSKICLDR QVPLYKKIIK KLLES

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..105] PSI-BLAST 15.69897 CRYSTAL STRUCTURE OF CONNECTIVE TISSUE ACTIVATING PEPTIDE-III(CTAP-III) COMPLEXED WITH POLYVINYLSULFONIC ACID


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle