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A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG). The lipid bilayer surrounding the platelet alpha granule. A membrane-bounded vesicle found in the cytoplasm of the cell. The volume enclosed by the membrane of the platelet alpha granule. A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: platelet alpha granule
Acc: GO:0031091
Aspect: Cellular Component
Desc: A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).
Synonyms:
  • platelet alpha-granule
Proteins in PDR annotated with:
   This term: 18 [Search]
   Term or descendants: 96 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031091 - platelet alpha granule (interactive image map)

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