Protein Overview: ERBB2_RAT

General Information:
Name(s) found:	ERBB2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|3915663\|sp\|P06494.3\|ERBB2_RAT RecName: Full=Receptor tyrosine-protein kinase erbB-2; AltName: Full=p185erbB2; AltName: Full=C-erbB-2; AltName: Full=NEU proto-oncogene; AltName: Full=Epidermal growth factor receptor-related protein; AltName: CD_antigen= [NCBI NR] Receptor tyrosine-protein kinase erbB-2 OS=Rattus norvegicus GN=Erbb2 PE=1 SV=3 [Swiss-Prot] (P06494) Receptor protein-tyrosine kinase erbB-2 precursor (EC 2.7.1.112) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Epidermal growth factor receptor-related protein) [Swiss-Prot] Ensembl_locations(Chr-bp):10-85616323 Receptor protein-tyrosine kinase erbB-2 precursor [hmr_yeast5_DM3-1_pombe.fasta] Receptor protein-tyrosine kinase erbB-2 precursor (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Epidermal growth factor receptor-related protein) [nrdb_11152004_Chlamydomonas] Receptor tyrosine-protein kinase erbB-2 precursor (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Epidermal growth factor receptor-related protein) (CD340 antigen) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Receptor tyrosine-protein kinase erbB-2 precursor (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Epidermal growth factor receptor-related protein) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Erbb2 Receptor tyrosine-protein kinase erbB-2 [rat-ipi-250309-contam.fasta] Receptor tyrosine-protein kinase erbB-2 OS=Rattus norvegicus GN=Erbb2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1257 amino acids
Gene Ontology:
Cellular Component:	lateral loop [IDA] nucleus [IDA] basal plasma membrane [IDA] perinuclear region of cytoplasm [IDA] cytoplasm [UNKNOWN][IEA] microvillus [IDA] postsynaptic membrane [IDA] membrane raft [IDA] integral to membrane [IEA] receptor complex [UNKNOWN][IEA] basolateral plasma membrane [UNKNOWN][IDA] apical plasma membrane [UNKNOWN][IDA]
Biological Process:	positive regulation of MAP kinase activity [UNKNOWN][IEA] peptidyl-tyrosine phosphorylation [IEA] positive regulation of phosphoinositide 3-kinase cascade [IMP] motor axon guidance [UNKNOWN][IEA] phosphoinositide 3-kinase cascade [UNKNOWN] negative regulation of immature T cell proliferation in the thymus [UNKNOWN][IEA] positive regulation of cell proliferation [IMP] response to progesterone stimulus [IEP] nervous system development [UNKNOWN] positive regulation of Ras protein signal transduction [IMP] protein amino acid autophosphorylation [UNKNOWN][IDA] myelination [UNKNOWN][IEA] response to axon injury [IDA] tongue development [IEP] positive regulation of cell adhesion [UNKNOWN][IEA] estrus [IMP] neuromuscular junction development [UNKNOWN][IEA] sympathetic nervous system development [IMP] heart development [UNKNOWN][IEA] wound healing [UNKNOWN][IEA] regulation of cell differentiation [TAS] liver development [IEP] positive regulation of epithelial cell proliferation [UNKNOWN][IEA] mammary gland involution [IEP] signal transduction [UNKNOWN] transmembrane receptor protein tyrosine kinase signaling pathway [UNKNOWN][IEA] peripheral nervous system development [UNKNOWN][IMP] cell surface receptor linked signaling pathway [UNKNOWN] positive regulation of MAPKKK cascade [IMP] regulation of cell proliferation [TAS] central nervous system development [TAS] skeletal muscle tissue development [IEP] response to drug [IEP] negative regulation of apoptosis [IMP] glial cell differentiation [IGI]
Molecular Function:	growth factor binding [UNKNOWN][IEA] identical protein binding [UNKNOWN][IEA] protein phosphatase binding [UNKNOWN][IEA] protein C-terminus binding [UNKNOWN][IEA] receptor activity [IEA] nucleotide binding [IEA] ATP binding [IEA] protein tyrosine kinase activity [UNKNOWN][IDA] transmembrane receptor activity [UNKNOWN][IEA] protein binding [UNKNOWN][IPI] ubiquitin protein ligase binding [IPI] transmembrane receptor protein tyrosine kinase activity [UNKNOWN][IEA] protein heterodimerization activity [UNKNOWN][IPI] receptor signaling protein tyrosine kinase activity [IEA] glycoprotein binding [IPI] Hsp90 protein binding [IPI] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELAAWCRWG FLLALLPPGI AGTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL  60
   61 ELTYVPANAS LSFLQDIQEV QGYMLIAHNQ VKRVPLQRLR IVRGTQLFED KYALAVLDNR 120
  121 DPQDNVAAST PGRTPEGLRE LQLRSLTEIL KGGVLIRGNP QLCYQDMVLW KDVFRKNNQL 180
  181 APVDIDTNRS RACPPCAPAC KDNHCWGESP EDCQILTGTI CTSGCARCKG RLPTDCCHEQ 240
  241 CAAGCTGPKH SDCLACLHFN HSGICELHCP ALVTYNTDTF ESMHNPEGRY TFGASCVTTC 300
  301 PYNYLSTEVG SCTLVCPPNN QEVTAEDGTQ RCEKCSKPCA RVCYGLGMEH LRGARAITSD 360
  361 NVQEFDGCKK IFGSLAFLPE SFDGDPSSGI APLRPEQLQV FETLEEITGY LYISAWPDSL 420
  421 RDLSVFQNLR IIRGRILHDG AYSLTLQGLG IHSLGLRSLR ELGSGLALIH RNAHLCFVHT 480
  481 VPWDQLFRNP HQALLHSGNR PEEDLCVSSG LVCNSLCAHG HCWGPGPTQC VNCSHFLRGQ 540
  541 ECVEECRVWK GLPREYVSDK RCLPCHPECQ PQNSSETCFG SEADQCAACA HYKDSSSCVA 600
  601 RCPSGVKPDL SYMPIWKYPD EEGICQPCPI NCTHSCVDLD ERGCPAEQRA SPVTFIIATV 660
  661 VGVLLFLILV VVVGILIKRR RQKIRKYTMR RLLQETELVE PLTPSGAMPN QAQMRILKET 720
  721 ELRKVKVLGS GAFGTVYKGI WIPDGENVKI PVAIKVLREN TSPKANKEIL DEAYVMAGVG 780
  781 SPYVSRLLGI CLTSTVQLVT QLMPYGCLLD HVREHRGRLG SQDLLNWCVQ IAKGMSYLED 840
  841 VRLVHRDLAA RNVLVKSPNH VKITDFGLAR LLDIDETEYH ADGGKVPIKW MALESILRRR 900
  901 FTHQSDVWSY GVTVWELMTF GAKPYDGIPA REIPDLLEKG ERLPQPPICT IDVYMIMVKC 960
  961 WMIDSECRPR FRELVSEFSR MARDPQRFVV IQNEDLGPSS PMDSTFYRSL LEDDDMGDLV1020
 1021 DAEEYLVPQQ GFFSPDPTPG TGSTAHRRHR SSSTRSGGGE LTLGLEPSEE GPPRSPLAPS1080
 1081 EGAGSDVFDG DLAMGVTKGL QSLSPHDLSP LQRYSEDPTL PLPPETDGYV APLACSPQPE1140
 1141 YVNQSEVQPQ PPLTPEGPLP PVRPAGATLE RPKTLSPGKN GVVKDVFAFG GAVENPEYLV1200
 1201 PREGTASPPH PSPAFSPAFD NLYYWDQNSS EQGPPPSNFE GTPTAENPEY LGLDVPV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ERBB2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: