Protein Overview: NRG1_RAT

General Information:
Name(s) found:	NRG1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|9297000\|sp\|P43322.1\|NRG1_RAT RecName: Full=Pro-neuregulin-1, membrane-bound isoform; Short=Pro-NRG1; Contains: RecName: Full=Neuregulin-1; AltName: Full=Neu differentiation factor; AltName: Full=Heregulin; Short=HRG; AltName: Full=Acetylcholine recepto [NCBI NR] pir\|\|I61722 neu differentiation factor - rat [NCBI NR] gi\|408395\|gb\|AAA19947.1\| neu differentiation factor [NCBI NR] Pro-neuregulin-1, membrane-bound isoform OS=Rattus norvegicus GN=Nrg1 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):16-60291391 Splice isoform Beta4 of P43322 [hmr_yeast5_DM3-1_pombe.fasta] Pro-neuregulin-1 precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Acetylcholine receptor inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)]gi\|7459673\|pir\|\|I61722 neu diff [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform Beta4 of Pro-neuregulin-1, membrane-bound isoform precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 Splice Isoform Beta4 of Pro-neuregulin-1 precursor [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta] Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] neu differentiation factor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF PRO-NEUREGULIN-1 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Nrg1 Isoform Beta4 of Pro-neuregulin-1, membrane-bound isoform [rat-ipi-250309-contam.fasta] Isoform Beta4 of Pro-neuregulin-1, membrane-bound isoform OS=Rattus norvegicus GN=Nrg1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	662 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [UNKNOWN] extracellular space [UNKNOWN] cytoplasm [UNKNOWN] integral to membrane [IEA] synapse [UNKNOWN] extracellular region [IEA] plasma membrane [UNKNOWN][IEA] apical plasma membrane [UNKNOWN]
Biological Process:	activation of transmembrane receptor protein tyrosine kinase activity [UNKNOWN] cell proliferation [UNKNOWN] embryonic development [IEA] positive regulation of cardiac muscle cell proliferation [UNKNOWN] ventricular cardiac muscle cell differentiation [UNKNOWN] nervous system development [UNKNOWN] positive regulation of Ras protein signal transduction [UNKNOWN] myelination [IEP] positive regulation of cell adhesion [UNKNOWN] cellular protein complex disassembly [UNKNOWN] negative regulation of secretion [UNKNOWN] MAPKKK cascade [UNKNOWN] heart development [UNKNOWN] positive regulation of cell growth [UNKNOWN] wound healing [UNKNOWN] locomotory behavior [UNKNOWN] anti-apoptosis [UNKNOWN] regulation of cell differentiation [UNKNOWN] neuron fate commitment [UNKNOWN] cell migration [UNKNOWN] cell morphogenesis [UNKNOWN] regulation of protein heterodimerization activity [UNKNOWN] transmembrane receptor protein tyrosine kinase signaling pathway [UNKNOWN] peripheral nervous system development [UNKNOWN] neurotransmitter receptor metabolic process [UNKNOWN] regulation of blood pressure [IEP] muscle organ development [UNKNOWN] synapse assembly [UNKNOWN] positive regulation of protein kinase activity [UNKNOWN] negative regulation of transcription [UNKNOWN] negative regulation of cardiac muscle cell apoptosis [UNKNOWN] glucose transport [IMP] glial cell differentiation [UNKNOWN]
Molecular Function:	growth factor activity [UNKNOWN][IEA] transcription cofactor activity [UNKNOWN] protein binding [UNKNOWN] ErbB-2 class receptor binding [UNKNOWN] protein tyrosine kinase activator activity [UNKNOWN] ErbB-3 class receptor binding [UNKNOWN][IMP] receptor binding [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSERKEGRGK GKGKKKDRGS RGKPGPAEGD PSPALPPRLK EMKSQESAAG SKLVLRCETS  60
   61 SEYSSLRFKW FKNGNELNRK NKPENIKIQK KPGKSELRIN KASLADSGEY MCKVISKLGN 120
  121 DSASANITIV ESNEFITGMP ASTETAYVSS ESPIRISVST EGANTSSSTS TSTTGTSHLI 180
  181 KCAEKEKTFC VNGGECFTVK DLSNPSRYLC KCPNEFTGDR CQNYVMASFY MTSRRKRQET 240
  241 EKPLERKLDH SLVKESKAEE LYQKRVLTIT GICIALLVVG IMCVVAYCKT KKQRQKLHDR 300
  301 LRQSLRSERS NLVNIANGPH HPNPPPENVQ LVNQYVSKNV ISSEHIVERE VETSFSTSHY 360
  361 TSTAHHSTTV TQTPSHSWSN GHTESVISES NSVIMMSSVE NSRHSSPAGG PRGRLHGLGG 420
  421 PRDNSFLRHA RETPDSYRDS PHSERYVSAM TTPARMSPVD FHTPSSPKSP PSEMSPPVSS 480
  481 MTVSMPSVAV SPFVEEERPL LLVTPPRLRE KKYDHHPQQL NSFHHNPAHQ STSLPPSPLR 540
  541 IVEDEEYETT QEYESVQEPV KKVTNSRRAK RTKPNGHIAN RLEMDSNTSS VSSNSESETE 600
  601 DERVGEDTPF LGIQNPLAAS LEVAPAFRLA ESRTNPAGRF STQEELQARL SSVIANQDPI 660
  661 AV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: NRG1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: