Protein Overview: GHRL_RAT

General Information:
Name(s) found:	GHRL_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6691570\|dbj\|BAA89370.1\| ghrelin precursor [Rattus norvegicus] [NCBI NR] gi\|17865453\|sp\|Q9QYH7.1\|GHRL_RAT RecName: Full=Appetite-regulating hormone; AltName: Full=Growth hormone secretagogue; AltName: Full=Growth hormone-releasing peptide; AltName: Full=Motilin-related peptide; Contains: RecName: Full=Ghrelin; Contains: RecNam [NCBI NR] gi\|149036939\|gb\|EDL91557.1\| ghrelin precursor, isoform CRA_a [Rattus norvegicus] [NCBI NR] pir\|\|B59316 ghrelin precursor - rat [NCBI NR] gi\|11067387\|ref\|NP_067701.1\| ghrelin/obestatin prepropeptide precursor [Rattus norvegicus] [NCBI NR] Appetite-regulating hormone OS=Rattus norvegicus GN=Ghrl PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):4-154913631 Splice isoform 1 of Q9QYH7 [hmr_yeast5_DM3-1_pombe.fasta] ghrelin precursor [HMR_022704-rand.fasta] ghrelin precursor [Rattus norvegicus]gi\|11381447\|pir\|\|B59316 ghrelin precursor - ratgi\|6691570\|dbj\|BAA89370.1\| ghrelin precursor [Rattus norvegicus]gi\|17865453\|sp\|Q9QYH7\|GHRL_RAT Ghrelin precursor (Growth hormone secretagogue) (Growth hormone releasing [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform 1 of Appetite-regulating hormone precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tax_Id=10116 Splice Isoform 1 of Ghrelin precursor [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] (NM_021669) ghrelin precursor [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] ghrelin precursor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Appetite-regulating hormone precursor (Growth hormone secretagogue) (Growth hormone-releasing peptide) (Motilin-related peptide) [Contains: Ghrelin; Obestatin-23; Obestatin-13] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ghrelin precursor, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF GHRELIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] ghrelin/obestatin prepropeptide precursor [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Ghrl Isoform 1 of Appetite-regulating hormone [rat-ipi-250309-contam.fasta] Isoform 1 of Appetite-regulating hormone OS=Rattus norvegicus GN=Ghrl [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	117 amino acids
Gene Ontology:
Cellular Component:	extracellular space [UNKNOWN][IC][ISS] cytoplasm [UNKNOWN][IEA] extracellular region [UNKNOWN][IEA][ISS] axon [UNKNOWN][ISS]
Biological Process:	negative regulation of tumor necrosis factor biosynthetic process [UNKNOWN][ISS] negative regulation of interleukin-6 biosynthetic process [UNKNOWN][ISS] regulation of response to food [IDA] negative regulation of locomotion [UNKNOWN][IEA] response to estrogen stimulus [UNKNOWN][ISS] positive regulation of growth hormone secretion [UNKNOWN][IEA] positive regulation of response to food [IDA] negative regulation of interleukin-1 beta production [UNKNOWN][ISS] decidualization [UNKNOWN][ISS] adult feeding behavior [ISS] negative regulation of insulin secretion [UNKNOWN][IDA] activation of MAPK activity [UNKNOWN][ISS] positive regulation of cortisol secretion [UNKNOWN][IEA] anti-apoptosis [IDA] positive regulation of adrenocorticotropin secretion [UNKNOWN][IEA] positive regulation of appetite [UNKNOWN][ISS] positive regulation of insulin secretion [IDA] positive regulation of synaptogenesis [UNKNOWN][IEA] dendrite development [UNKNOWN][IEA] regulation of excitatory postsynaptic membrane potential [UNKNOWN][IEA] G-protein coupled receptor protein signaling pathway [IDA] actin polymerization or depolymerization [UNKNOWN][ISS] negative regulation of inflammatory response [UNKNOWN][ISS] negative regulation of circadian sleep/wake cycle, REM sleep [UNKNOWN][IEA] response to hormone stimulus [UNKNOWN][ISS] regulation of cell proliferation [UNKNOWN][ISS] elevation of cytosolic calcium ion concentration [IDA] gastric acid secretion [IDA] positive regulation of circadian sleep/wake cycle, non-REM sleep [UNKNOWN][IEA] negative regulation of apoptosis [UNKNOWN][ISS] negative regulation of endothelial cell proliferation [UNKNOWN][ISS]
Molecular Function:	G-protein-coupled receptor binding [IPI] ghrelin receptor binding [IMP] growth hormone-releasing hormone activity [IDA][IEA] protein tyrosine kinase activator activity [UNKNOWN][ISS] hormone activity [IDA]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MVSSATICSL LLLSMLWMDM AMAGSSFLSP EHQKAQQRKE SKKPPAKLQP RALEGWLHPE 60 61 DRGQAEEAEE ELEIRFNAPF DVGIKLSGAQ YQQHGRALGK FLQDILWEEV KEAPANK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

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No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..117]	Pfam	35.154902	No description for PF04643.3 was found. No confident structure predictions are available.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

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Source: Reynolds et al. 2008. Manuscript submitted

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