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Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells. Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. Any process that modulates the frequency, rate or extent of the regulated release of insulin. Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion. The regulated release of a peptide hormone from vesicles or secretory granules. The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin. Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of insulin.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of insulin secretion
Acc: GO:0046676
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of insulin.
Synonyms:
  • inhibition of insulin secretion
  • down-regulation of insulin secretion
  • downregulation of insulin secretion
  • down regulation of insulin secretion
Proteins in PDR annotated with:
   This term: 47 [Search]
   Term or descendants: 47 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0046676 - negative regulation of insulin secretion (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle