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Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines. Any process that modulates the frequency, rate, or extent of tumor necrosis factor production. The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis. The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of tumor necrosis factor biosynthetic process
Acc: GO:0042536
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
Synonyms:
  • negative regulation of tumor necrosis factor synthesis
  • negative regulation of tumor necrosis factor-alpha biosynthesis
  • negative regulation of tumor necrosis factor anabolism
  • down-regulation of tumor necrosis factor biosynthetic process
  • negative regulation of TNF biosynthetic process
  • negative regulation of TNF-alpha biosynthesis
  • negative regulation of TNF biosynthesis
  • down regulation of tumor necrosis factor biosynthetic process
  • inhibition of tumor necrosis factor biosynthetic process
  • negative regulation of tumor necrosis factor biosynthesis
  • negative regulation of TNF alpha biosynthesis
  • negative regulation of TNF alpha biosynthetic process
  • negative regulation of TNF-alpha biosynthetic process
  • negative regulation of tumor necrosis factor formation
  • negative regulation of tumor necrosis factor-alpha biosynthetic process
  • downregulation of tumor necrosis factor biosynthetic process
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 6 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0042536 - negative regulation of tumor necrosis factor biosynthetic process (interactive image map)
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