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Protein Overview: DRD1_RAT

General Information:
Name(s) found: DRD1_RAT [Swiss-Prot]
Description(s) found:
Found 14 descriptions.
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  • D(1A) dopamine receptor OS=Rattus norvegicus GN=Drd1 PE=1 SV=2 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 446 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [UNKNOWN][IEA]
    endoplasmic reticulum membrane [IEA]
    nucleus [UNKNOWN][IEA]
    dendrite [IDA]
    caveola [IDA]
    dendritic spine [IDA]
    integral to membrane [IDA]
    endoplasmic reticulum [IDA]
    neuronal cell body [IDA]
    plasma membrane [UNKNOWN][IDA]
    axon [IDA]
    Biological Process: dopamine transport [UNKNOWN][IEA]
    phosphatidylinositol catabolic process [IDA]
    dopamine receptor signaling pathway [UNKNOWN][IDA][IMP][TAS]
    visual learning [UNKNOWN][IMP]
    positive regulation of adenylate cyclase activity [IDA]
    striatum development [UNKNOWN][IEA]
    intracellular protein transport [IMP]
    learning [UNKNOWN]
    associative learning [UNKNOWN][IMP]
    memory [UNKNOWN][IEA]
    regulation of ion transport [IDA]
    behavior [UNKNOWN]
    regulation of long-term neuronal synaptic plasticity [IMP]
    elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger [UNKNOWN][IEA]
    phosphoinositide metabolic process [IDA]
    long-term synaptic potentiation [UNKNOWN][IEA]
    positive regulation of synaptic transmission, glutamatergic [UNKNOWN][IEA]
    long term synaptic depression [UNKNOWN][IEA]
    calcium-mediated signaling [IDA]
    G-protein coupled receptor protein signaling pathway [UNKNOWN]
    G-protein signaling, coupled to cyclic nucleotide second messenger [UNKNOWN][IEA]
    positive regulation of cAMP biosynthetic process [UNKNOWN][IMP]
    response to cocaine [UNKNOWN]
    activation of adenylate cyclase activity by G-protein signaling pathway [UNKNOWN]
    activation of phospholipase C activity by dopamine receptor signaling pathway [UNKNOWN][IEA]
    dentate gyrus development [UNKNOWN][IEA]
    mating behavior [UNKNOWN][IEA]
    synapse assembly [IEP]
    protein import into nucleus [UNKNOWN][IEA]
    negative regulation of cell migration [IMP]
    positive regulation of cell migration [UNKNOWN][IEA]
    operant conditioning [UNKNOWN][IMP]
    activation of adenylate cyclase activity by dopamine receptor signaling pathway [UNKNOWN][IDA]
    astrocyte development [UNKNOWN][IEA]
    feeding behavior [UNKNOWN]
    cerebral cortex GABAergic interneuron migration [UNKNOWN][IEA]
    negative regulation of protein kinase activity [IMP]
    eating behavior [IMP]
    cellular response to insulin stimulus [IEP]
    adult walking behavior [UNKNOWN][IEA]
    grooming behavior [UNKNOWN][IEA]
    synaptic transmission, dopaminergic [UNKNOWN][IDA][IMP]
    locomotory behavior [UNKNOWN][IMP]
    [NOT]startle response [UNKNOWN]
    behavioral response to cocaine [UNKNOWN][IMP]
    sensitization [UNKNOWN][IEA]
    muscle contraction [UNKNOWN][IEA]
    activation of adenylate cyclase activity [UNKNOWN][IDA]
    transmission of nerve impulse [UNKNOWN]
    regulation of action potential in neuron [UNKNOWN][IEA]
    [NOT]prepulse inhibition [UNKNOWN]
    signal transduction [IEA]
    hippocampus development [UNKNOWN]
    negative regulation of circadian sleep/wake cycle, sleep [IDA]
    glucose import [UNKNOWN][IEA]
    positive regulation of release of sequestered calcium ion into cytosol [UNKNOWN][IEA]
    conditioned taste aversion [UNKNOWN][IEA]
    behavioral fear response [UNKNOWN][IEA]
    response to amphetamine [UNKNOWN][IEA]
    regulation of dopamine metabolic process [UNKNOWN][IEA]
    response to drug [UNKNOWN][IEA][IEP]
    temperature homeostasis [UNKNOWN][IEA]
    peristalsis [UNKNOWN][IEA]
    Molecular Function: G-protein coupled receptor activity [UNKNOWN][IDA]
    dopamine receptor activity [UNKNOWN][IEA]
    dopamine receptor activity, coupled via Gs [UNKNOWN]
    protein binding [UNKNOWN][IPI]
    drug binding [IDA]
    dopamine binding [UNKNOWN]
    dopamine D1 receptor activity [UNKNOWN][IDA][IMP]
    receptor activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPNTSTMDE AGLPAERDFS FRILTACFLS LLILSTLLGN TLVCAAVIRF RHLRSKVTNF  60
   61 FVISLAVSDL LVAVLVMPWK AVAEIAGFWP LGPFCNIWVA FDIMCSTASI LNLCVISVDR 120
  121 YWAISSPFQY ERKMTPKAAF ILISVAWTLS VLISFIPVQL SWHKAKPTWP LDGNFTSLED 180
  181 TEDDNCDTRL SRTYAISSSL ISFYIPVAIM IVTYTSIYRI AQKQIRRISA LERAAVHAKN 240
  241 CQTTAGNGNP VECAQSESSF KMSFKRETKV LKTLSVIMGV FVCCWLPFFI SNCMVPFCGS 300
  301 EETQPFCIDS ITFDVFVWFG WANSSLNPII YAFNADFQKA FSTLLGCYRL CPTTNNAIET 360
  361 VSINNNGAVV FSSHHEPRGS ISKDCNLVYL IPHAVGSSED LKKEEAGGIA KPLEKLSPAL 420
  421 SVILDYDTDV SLEKIQPVTH SGQHST

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle