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Protein Overview: NCS1_RAT

General Information:
Name(s) found: NCS1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|7259217|emb|CAA57678.1| frequenin-like protein [Rattus norvegicus] [NCBI NR]
  • gi|498032|gb|AAA88510.1| neuronal calcium sensor [NCBI NR]
  • gi|49065665|sp|P62168.2|NCS1_RAT RecName: Full=Neuronal calcium sensor 1; Short=NCS-1; AltName: Full=Frequenin homolog; AltName: Full=Frequenin-like protein; AltName: Full=Frequenin-like ubiquitous protein [NCBI NR]
  • gi|13242261|ref|NP_077342.1| neuronal calcium sensor-1 [Rattus norvegicus] [NCBI NR]
  • Neuronal calcium sensor 1 OS=Rattus norvegicus GN=Ncs1 PE=1 SV=2 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):3-10382266 neuronal calcium sensor-1 [hmr_yeast5_DM3-1_pombe.fasta]
  • neuronal calcium sensor-1 [HMR_022704-rand.fasta]
  • frequenin homolog [Mus musculus]gi|17738308|ref|NP_055101.2| frequenin homolog [Homo sapiens]gi|13242261|ref|NP_077342.1| neuronal calcium sensor-1 [Rattus norvegicus]gi|33150756|gb|AAP97256.1| neuronal calcium sensor [Homo sapiens]gi|45382423|ref|NP_ [nrdb_11152004_Chlamydomonas]
  • (NM_024366) neuronal calcium sensor-1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • neuronal calcium sensor-1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • frequenin-like protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • neuronal calcium sensor [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 NEURONAL CALCIUM SENSOR-1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Freq Neuronal calcium sensor 1 [rat-ipi-250309-contam.fasta]
  • neuronal calcium sensor 1 [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Neuronal calcium sensor 1 OS=Rattus norvegicus GN=Ncs1 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 190 amino acids

    Gene Ontology:
    Cellular Component: postsynaptic density [IEA]
    Golgi cisterna membrane [IEA]
    Golgi apparatus [IEA]
    synapse [IEA]
    plasma membrane [UNKNOWN][IEA]
    dendrite [UNKNOWN][IEA]
    perinuclear region of cytoplasm [IEA]
    cytoplasm [UNKNOWN][IEA]
    postsynaptic membrane [IEA]
    cytosol [IPI]
    cell junction [IEA]
    dense core granule [IDA]
    axon [UNKNOWN][IEA]
    Biological Process: phosphoinositide-mediated signaling [IDA]
    negative regulation of calcium ion transport via voltage-gated calcium channel activity [IMP]
    regulation of neuron projection development [IMP]
    positive regulation of exocytosis [IDA]
    Molecular Function: protein binding [UNKNOWN][IPI]
    calcium ion binding [TAS]
    calcium-dependent protein kinase inhibitor activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKSNSKLKP EVVEELTRKT YFTEKEVQQW YKGFIKDCPS GQLDAAGFQK IYKQFFPFGD  60
   61 PTKFATFVFN VFDENKDGRI EFSEFIQALS VTSRGTLDEK LRWAFKLYDL DNDGYITRNE 120
  121 MLDIVDAIYQ MVGNTVELPE EENTPEKRVD RIFAMMDKNA DGKLTLQEFQ EGSKADPSIV 180
  181 QALSLYDGLV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] PSI-BLAST 35.045757 Frequenin (neuronal calcium sensor 1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.47426847861728 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.37104157544514 bayes_pls_golite062009
  • phosphatase activity
    		•  6.28157965296365 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.17799259119197 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  5.58369939851095 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.11186887221409 bayes_pls_golite062009
  • calcium ion binding
    		•  3.79609619542776 bayes_pls_golite062009
  • binding
    		•  3.17556402087346 bayes_pls_golite062009
  • cation binding
    		•  2.62077305565026 bayes_pls_golite062009
  • metal ion binding
    		•  2.62077305565026 bayes_pls_golite062009
  • ion binding
    		•  2.61312132078717 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.57032504567157 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.55650624542181 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37465721152046 bayes_pls_golite062009
  • clathrin binding
    		•  2.36616108128297 bayes_pls_golite062009
  • protein binding
    		•  2.21291432166051 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase regulator activity
    		•  2.11312280020523 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.99763594451773 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.9739523190593 bayes_pls_golite062009
  • DNA binding
    		•  1.55722307354604 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.53225451586959 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.30577051923353 bayes_pls_golite062009
  • calcium-dependent protein kinase inhibitor activity
    		•  1.29632226581856 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • phosphatase regulator activity
    		•  0.87149881541475 bayes_pls_golite062009
  • guanylate cyclase regulator activity
    		•  0.84389905735679 bayes_pls_golite062009
  • cyclase regulator activity
    		•  0.84389905735679 bayes_pls_golite062009
  • protein phosphatase regulator activity
    		•  0.822713961141111 bayes_pls_golite062009
  • cation channel activity
    		•  0.802117767859521 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.787740261079819 bayes_pls_golite062009
  • kinase activity
    		•  0.782396352346639 bayes_pls_golite062009
  • calcium channel regulator activity
    		•  0.7164851905066 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.666488715029225 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.654002071540024 bayes_pls_golite062009
  • calcium sensitive guanylate cyclase activator activity
    		•  0.630360514213104 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.386960491413065 bayes_pls_golite062009
  • channel activity
    		•  0.386960491413065 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.362205423422174 bayes_pls_golite062009
    		• 0.34446792626966 bayes_pls_golite062009
  • ion channel activity
    		•  0.343477643719352 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.308919475701377 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.304496519713588 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.278054748078249 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.27738240687034 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • potassium channel activity
    		•  0.200283164564768 bayes_pls_golite062009
  • gated channel activity
    		•  0.150185445887481 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  0.109511951498555 bayes_pls_golite062009
  • motor activity
    		•  0.0886596083402598 bayes_pls_golite062009
  • protein complex binding
    		•  0.0676093357928913 bayes_pls_golite062009
  • structural molecule activity
    		•  0.048100972187449 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle