Protein Overview: TSC2_RAT

General Information:
Name(s) found:	TSC2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|31543896\|ref\|NP_036812.2\| tuberous sclerosis 2 [Rattus norvegicus] [NCBI NR] gi\|1717800\|sp\|P49816.1\|TSC2_RAT RecName: Full=Tuberin; AltName: Full=Tuberous sclerosis 2 homolog protein [NCBI NR] gi\|1061325\|gb\|AAC52289.1\| tuberous sclerosis 2 homolog [NCBI NR] Tuberin OS=Rattus norvegicus GN=Tsc2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):10-11911249 Splice isoform 1 of P49816 [hmr_yeast5_DM3-1_pombe.fasta] tuberous sclerosis 2; Tuberous sclerosis 2 (renal carcinoma); Tuberous sclerosis 2, (renal carcinoma); renal carcinoma [HMR_022704-rand.fasta] tuberous sclerosis 2 [Rattus norvegicus]gi\|1717800\|sp\|P49816\|TSC2_RAT Tuberin (Tuberous sclerosis 2 homolog protein)gi\|1061325\|gb\|AAC52289.1\| tuberous sclerosis 2 homolog [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform 1 of Tuberin [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Tuberin (Tuberous sclerosis 2 homolog protein) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] tuberous sclerosis 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] tuberous sclerosis 2 homolog [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF TUBERIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Tsc2 Isoform 1 of Tuberin [rat-ipi-250309-contam.fasta] Isoform 1 of Tuberin OS=Rattus norvegicus GN=Tsc2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1809 amino acids
Gene Ontology:
Cellular Component:	microsome [IDA] [NOT]Golgi apparatus [UNKNOWN][IEA] neuronal cell body [IDA] protein complex [IDA][IMP] neuron projection [IDA] intracellular [IEA] membrane fraction [UNKNOWN][IEA] growth cone [IDA] nucleus [UNKNOWN][IEA] dendrite [IDA] caveola [IDA] perinuclear region of cytoplasm [UNKNOWN][IDA] cytoplasm [UNKNOWN][IEA] cytoskeletal part [IDA] membrane raft [IDA] cytosol [UNKNOWN][IDA] TSC1-TSC2 complex [UNKNOWN][IEA]
Biological Process:	negative regulation of phosphoinositide 3-kinase cascade [UNKNOWN][IEA] negative regulation of MAP kinase activity [IMP] phosphoinositide 3-kinase cascade [UNKNOWN] positive chemotaxis [UNKNOWN][IEA] negative regulation of cell proliferation [UNKNOWN][IMP] cell projection organization [IMP] protein localization [UNKNOWN] regulation of stress fiber assembly [IMP] protein heterooligomerization [IDA][IMP] negative regulation of protein kinase activity [UNKNOWN] positive regulation of GTPase activity [IEA] heart development [UNKNOWN][IEA] protein kinase B signaling cascade [UNKNOWN] neural tube closure [UNKNOWN][IEA] negative regulation of cell size [IMP] regulation of endocytosis [UNKNOWN][IEA] regulation of cell cycle [IMP] negative regulation of TOR signaling pathway [IDA] signal transduction [IDA] insulin-like growth factor receptor signaling pathway [UNKNOWN][IEA] protein homooligomerization [IDA][IMP] regulation of insulin receptor signaling pathway [UNKNOWN][IEA] acute-phase response [IMP] establishment of protein localization [IMP] regulation of focal adhesion assembly [IMP] regulation of actin cytoskeleton organization [IMP] regulation of small GTPase mediated signal transduction [IEA] protein import into nucleus [UNKNOWN][IEA] negative regulation of epithelial cell proliferation [IDA] negative regulation of Wnt receptor signaling pathway [IDA] negative regulation of protein kinase B signaling cascade [UNKNOWN][IEA]
Molecular Function:	protein binding [UNKNOWN][IMP][IPI] protein homodimerization activity [UNKNOWN][IEA] protein heterodimerization activity [IPI] Rab GTPase activator activity [TAS] GTPase activator activity [UNKNOWN][IDA] GTPase regulator activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKPTSKDSG LKEKFKILLG LGTSRPNPRC AEGKQTEFII TAEILRELSG ECGLNNRIRM  60
   61 IGQICDVAKT KKLEEHAVEA LWKAVSDLLQ PERPPEARHA VLALLKAIVQ GQGDRLGVLR 120
  121 ALFFKVIKDY PSNEDLHERL EVFKALTDNG RHITYLEEEL AEFVLQWMDV GLSSEFLLVL 180
  181 VNLVKFNSCY LDEYIAPMVH MICLLCIRTV SSVDIEVSLQ VLDAVVCYNC LPAESLPLFI 240
  241 ITLCRTVNVK ELCEPCWKLM RNLLGTHLGH SAIYNMCRIM ENRSYMEDAP LLRGAVFFVG 300
  301 MALWGAHRLY SLKNSPTSVL PSFYEAMTCP NEVVSYEIVL SITRLIKKYR KELQAVTWDI 360
  361 LLDIIERLLQ QLQNLDSPEL RTIVHDLLTT VEELCDQNEF HGSQERYYEL VESYADQRPE 420
  421 SSLLNLITYR AQSIHPAKDG WIQNLQLLME RFFRNECRSA VRIKVLDVLS FVLLINRQFY 480
  481 EEELINSVVI SQLSHIPEDK DHQVRKLATQ LLVDLAEGCH THHFNSLLDI IEKVMARSLS 540
  541 PPLELEERDL AVYSASLEDV KTAVLGLLVI LQTKLYTLPA SHATRVYETL ISHIQLHYKH 600
  601 GYSLPIASSI RLQAFDFLLL LRADSLHRLG LPNKDGVVRF SPYCLCDCAE LDRASEKKAS 660
  661 GPLSPPTGPP SPVPTGPAVR LGHLPYSLLF RVLLQCLKQE TDWKVLKLVL SKLPESLRYK 720
  721 VLIFTSPCSV DQLSSALCSM LSAPKTLERL RGTPEGFSRT DLHLAVVPVL TALISYHNYL 780
  781 DKTRQREMVY CLEQGLIYRC ASQCVVALAI CSVEMPDIII KALPVLVVKL THISATASMA 840
  841 IPLLEFLSTL ARLPHLYRNF AAEQYASVFA ISLPYTNPSK FNQYIVCLAH HVIAMWFIRC 900
  901 RLPFRKDFVP YITKGLRSNV LLSFDDTPEK DKFRARSTSL NERPKSLRIA RAPKQGLNNS 960
  961 PPVKEFKESC AAEAFRCRSI SVSEHVVRSR IQTSLTSASL GSADENSMAQ ADDNLKNLHL1020
 1021 ELTETCLDMM ARYVFSNFTA VPKRSPVGEF LLAGGRTKTW LVGNKLVTVT TSVGTGTRSL1080
 1081 LGLDSGDLQG GSASSSDPGT HVRQTKEAPA KLESQAGQQV SRGARDRVRS MSGGHGLRVG1140
 1141 VLDTSAPYTP GGPASLGAQA APAARPEKPC AGAQLPAAEK ANLAAYVPLL TQGWAEILVR1200
 1201 RPTGNTSWLM SLENPLSPFS SDINNMPLQE LSNALMAAER FKEHRDTALY KSLSVPAAGT1260
 1261 AKPPTLPRSN TVASFSSLYQ PSCQGQLHRS VSWADSAVVL EEGSPGEAHV PVEPPELEDF1320
 1321 EAALGTDRHC QRPDAYSRSS SASSQEEKSH LEELAAGGIP IERAISSEGA RPTVDLSFQP1380
 1381 SQPLSKSSSS PELQTLQDIL GDLGDKTDIG RLSPEAKVRS QSGILDGEAA TWSAPGEESR1440
 1441 ITVPPEGPLP SSSPRSPSGL RPRGYTISDS APSRRGKRVE RDNFKSRTAA SSAEKVPGIN1500
 1501 PSFVFLQLYH SPFCGDESNK PILLPNESFE RSVQLLDQIP SYDTHKIAVL YVGEGQSSSE1560
 1561 LAILSNEHGS YRYTEFLTGL GRLIELKDCQ PDKVYLGGLD VCGEDGQFTY CWHDDIMQAV1620
 1621 FHIATLMPTK DVDKHRCDKK RHLGNDFVSI IYNDSGEDFK LGTIKGQFNF VHVIITPLDY1680
 1681 KCNLLTLQCR KDMEGLVDTS VAKIVSDRNL SFVARQMALH ANMASQVHHR RSNPTDIYPS1740
 1741 KWIARLRHIK RLRQRIREEV HYSNPSLPLM HPPAHTKVPA QAPTEATPTY ETGQRKRLIS1800
 1801 SVDDFTEFV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.44

Protein Overview: TSC2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: