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The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Any process that modulates the frequency, rate or extent of a signaling pathway. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade. Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade. A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of phosphoinositide 3-kinase cascade
Acc: GO:0014067
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by the phosphoinositide 3-kinase cascade.
Synonyms:
  • inhibition of phosphoinositide 3-kinase cascade
  • downregulation of phosphoinositide 3-kinase cascade
  • negative regulation of PI 3-kinase cascade
  • down-regulation of phosphoinositide 3-kinase cascade
  • negative regulation of PI3K cascade
  • down regulation of phosphoinositide 3-kinase cascade
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 5 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0014067 - negative regulation of phosphoinositide 3-kinase cascade (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle