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Protein Overview: TSC2_MOUSE

General Information:
Name(s) found: TSC2_MOUSE [Swiss-Prot]
Description(s) found:
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  • gi|9297076|sp|Q61037.1|TSC2_MOUSE RecName: Full=Tuberin; AltName: Full=Tuberous sclerosis 2 homolog protein [NCBI NR]
  • ref|NP_035777.1| tuberous sclerosis 2 [Mus musculus] [NCBI NR]
  • gi|1236402|gb|AAB18754.1| tuberin [Mus musculus] [NCBI NR]
  • Tuberin OS=Mus musculus GN=Tsc2 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):17-23284110 Splice isoform G of Q61037 Tuberin [hmr_yeast5_DM3-1_pombe.fasta]
  • tuberous sclerosis 2 [HMR_022704-rand.fasta]
  • Splice Isoform G of Tuberin [ipi.MOUSE.v3.06.fasta]
  • tuberous sclerosis 2 [Mus musculus]gi|9297076|sp|Q61037|TSC2_MOUSE Tuberin (Tuberous sclerosis 2 homolog protein)gi|1236402|gb|AAB18754.1| tuberin [Mus musculus] [nrdb_11152004_Chlamydomonas]
  • (NM_011647) tuberous sclerosis 2 [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • tuberous sclerosis 2 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta]
  • Tax_Id=10090 Splice Isoform G of Tuberin [EBI-IPI_mouse_3.06_05-10-2005_origrev_con.fasta]
  • Tuberin (Tuberous sclerosis 2 homolog protein) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • tuberin [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10090 SPLICE ISOFORM 1 OF TUBERIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10090 Gene_Symbol=Tsc2 Isoform G of Tuberin [mouse-ipi-250309-contam.fasta]
  • Tax_Id=10090 Gene_Symbol=Tsc2 Isoform G of Tuberin ENSMUSG00000002496 IPI00620969 IPI00468568 IPI00230482 IPI00875520 IPI00230479 IPI00874661 IPI00230481 IPI00230478 IPI00230480 [IPIxENS.MOUSE_plus_REVERSE.fasta]
  • IPI:IPI00620969.2|SWISS-PROT:Q61037-1|ENSEMBL:ENSMUSP00000085764 Tax_Id=10090 Gene_Symbol=Tsc2 Isoform G of Tuberin [ipi.MOUSE.fasta.20090209]
  • Isoform G of Tuberin OS=Mus musculus GN=Tsc2 [011711_HMR.fasta]
  • sp|Q61037|TSC2_MOUSE Tuberin OS=Mus musculus GN=Tsc2 PE=1 SV=1 [uniprot.sptr.mouse.20130102]
    • Organism: Mus musculus
    Length: 1814 amino acids

    Gene Ontology:
    Cellular Component: microsome [UNKNOWN]
    neuronal cell body [UNKNOWN]
    protein complex [UNKNOWN]
    neuron projection [UNKNOWN]
    intracellular [IEA]
    growth cone [UNKNOWN]
    nucleus [UNKNOWN]
    dendrite [UNKNOWN]
    caveola [UNKNOWN]
    perinuclear region of cytoplasm [UNKNOWN]
    cytoplasm [IDA]
    cytoskeletal part [UNKNOWN]
    membrane [IEA]
    membrane raft [UNKNOWN]
    cytosol [UNKNOWN]
    Biological Process: negative regulation of phosphoinositide 3-kinase cascade [IMP]
    negative regulation of MAP kinase activity [UNKNOWN]
    phosphoinositide 3-kinase cascade [IMP]
    positive chemotaxis [IMP]
    negative regulation of cell proliferation [UNKNOWN][IGI][IMP]
    cell projection organization [UNKNOWN]
    protein localization [IDA]
    regulation of stress fiber assembly [UNKNOWN]
    protein heterooligomerization [UNKNOWN]
    negative regulation of protein kinase activity [IMP]
    positive regulation of GTPase activity [IEA]
    heart development [IMP]
    protein kinase B signaling cascade [IGI][IMP]
    neural tube closure [IMP]
    negative regulation of cell size [UNKNOWN]
    regulation of cell cycle [UNKNOWN]
    regulation of endocytosis [IMP]
    negative regulation of TOR signaling pathway [UNKNOWN]
    signal transduction [UNKNOWN]
    protein homooligomerization [UNKNOWN]
    insulin-like growth factor receptor signaling pathway [IGI][IMP]
    regulation of insulin receptor signaling pathway [IMP]
    acute-phase response [UNKNOWN]
    establishment of protein localization [UNKNOWN]
    regulation of focal adhesion assembly [UNKNOWN]
    regulation of actin cytoskeleton organization [UNKNOWN]
    regulation of small GTPase mediated signal transduction [IEA]
    protein import into nucleus [IMP]
    negative regulation of epithelial cell proliferation [UNKNOWN]
    negative regulation of Wnt receptor signaling pathway [UNKNOWN]
    negative regulation of protein kinase B signaling cascade [IGI][IMP]
    Molecular Function: protein binding [IPI]
    protein heterodimerization activity [UNKNOWN]
    GTPase activator activity [UNKNOWN]
    GTPase regulator activity [UNKNOWN]
    binding [IEA]
    receptor binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKPTSKDSG LKEKFKILLG LGTSRPNPRC AEGKQTEFII TSEILRELSG ECGLNNRIRM  60
   61 IGQICDVAKT KKLEEHAVEA LWKAVSDLLQ PERPPEARHA VLTLLKAIVQ GQGDRLGVLR 120
  121 ALFFKVIKDY PSNEDLHERL EVFKALTDNG RHITYLEEEL AEFVLQWMDV GLSSEFLLVL 180
  181 VNLVKFNSCY LDEYIASMVH MICLLCIRTV SSVDIEVSLQ VLDAVVCYNC LPAESLPLFI 240
  241 ITLCRTINVK ELCEPCWKLM RNLLGTHLGH SAIYNMCRIM EDRSYMEDAP LLRGAVFFVG 300
  301 MALWGAHRLY SLKNSPTSVL PSFYEAMTCP NEVVSYEIVL SITRLIKKYR KELQAVTWDI 360
  361 LLDIIERLLQ QLQNLDSPEL KTIVHDLLTT VEELCDQNEF HGSQERYYEL VESYADQRPE 420
  421 SSLLNLISYR AQSIHPAKDG WIQNLQLLME RFFRNECRSA VAIKVLDVLS FVLLIIRQFY 480
  481 EEELINSVVI SQLSHIPEDK DHQVRKLATQ LLVDLAEGCH THHFNSLLDI IEKVMARSLS 540
  541 PPPELEERDL AVHSASLEDV KTAVLGLLVI LQTKLYTLPA SHATRVYESL ISHIQLHYKH 600
  601 GYSLPIASSI RLQAFDFLLL LRADSLHRLG LPNKDGVVRF SPYCLCDCME LDRASEKKAS 660
  661 GPLSPPTGPP SPVPMGPAVR LGYLPYSLLF RVLLQCLKQE SDWKVLKLVL SRLPESLRYK 720
  721 VLIFTSPCSV DQLSSALCSM LSAPKTLERL RGTPEGFSRT DLHLAVVPVL TALISYHNYL 780
  781 DKTRQREMVY CLEQGLIYRC ASQCVVALAI CSVEMPDIII KALPVLVVKL THISATASMA 840
  841 IPLLEFLSTL ARLPHLYRNF VPEQYASVFA ISLPYTNPSK FNQYIVCLAH HVIAMWFIRC 900
  901 RLPFRKDFVP YITKGLRSNV LLSFDDTPEK DSFRARSTSL NERPKSLRIA RAPKQGLNNS 960
  961 PPVKEFKESC AAEAFRCRSI SVSEHVVRSR IQTSLTSASL GSADENSMAQ ADDNLKNLHL1020
 1021 ELTETCLDMM ARYVFSNFTA VPKRSPVGEF LLAGGRTKTW LVGNKLVTVT TSVGTGTRSL1080
 1081 LGLDSGDLQG GSDSSSDPST HVRQTKEAPA KLESQAGQQV SRGARDRVRS MSGGHGLRVG1140
 1141 VLDTSAPYSP GGSASLGPQT AVAAKPEKPP AGAQLPTAEK TNLAAYVPLL TQGWAEILVR1200
 1201 RPTGNTSWLM SLENPLSPFS SDINNMPLQE LSNALMAAER FKEHGHAPVQ VIVSATGCTA1260
 1261 KPPTLPRSNT VASFSSLYQP SCQGQLHRSV SWADSAMVLE EGSPGETQVP VEPPELEDFE1320
 1321 AALGTDRHCQ RPDTYSRSSS ASSQEEKSHL EELAAGGIPI ERAISSEGAR PAVDLSFQPS1380
 1381 QPLSKSSSSP ELQTLQDILG DLGDKIDIGR LSPEAKVRSQ SGILDGEAAT WSATGEESRI1440
 1441 TVPPEGPLPS SSPRSPSGLR PRGYTISDSA PSRRGKRVER DNFKSRAAAS SAEKVPGINP1500
 1501 SFVFLQLYHS PFFGDESNKP ILLPNESFER SVQLLDQIPS YDTHKIAVLY VGEGQSSSEL1560
 1561 AILSNEHGSY RYTEFLTGLG RLIELKDCQP DKVYLGGLDV CGEDGQFTYC WHDDIMQAVF1620
 1621 HIATLMPTKD VDKHRCDKKR HLGNDFVSII YNDSGEDFKL GTIKQGQFNF VHVIITPLDY1680
 1681 KCNLLTLQCR KDGPACKCEW WRQPGEIVVW ALPVVMELTV TILLCHLQMA SQVHHSRSNP1740
 1741 TDIYPSKWIA RLRHIKRLRQ RIREEVHYSN PSLPLMHPPA HTKAPAQAPE ATPTYETGQR1800
 1801 KRLISSVDDF TEFV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.35

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle