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Protein Overview: APC_MOUSE

General Information:
Name(s) found: APC_MOUSE [Swiss-Prot]
Description(s) found:
Found 20 descriptions.
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  • Adenomatous polyposis coli protein OS=Mus musculus GN=Apc PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 2845 amino acids

    Gene Ontology:
    Cellular Component: growth cone [UNKNOWN][IDA]
    nucleus [UNKNOWN][IDA]
    lateral plasma membrane [UNKNOWN]
    cytoplasm [UNKNOWN][IDA]
    cell junction [IEA]
    axon part [IDA]
    cell projection membrane [IDA]
    cytoplasmic microtubule [IDA]
    neuron projection [UNKNOWN]
    cell projection [IDA]
    microtubule [UNKNOWN]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [UNKNOWN]
    retina development in camera-type eye [IMP]
    axis specification [IMP]
    anterior/posterior pattern formation [IMP]
    regulation of nitrogen compound metabolic process [IMP]
    skin development [IMP]
    proximal/distal pattern formation [IMP]
    dorsal/ventral pattern formation [IMP]
    hair follicle development [IMP]
    kidney development [IMP]
    axonogenesis [IMP]
    Wnt receptor signaling pathway [IDA][IMP]
    regulation of cell cycle [IMP]
    positive regulation of microtubule polymerization [IMP]
    mitotic metaphase/anaphase transition [IGI][IMP]
    stem cell maintenance [IMP]
    positive regulation of pseudopodium assembly [UNKNOWN]
    pattern specification process [IMP]
    positive regulation of protein catabolic process [UNKNOWN][IMP]
    negative regulation of microtubule depolymerization [UNKNOWN][IMP]
    regulation of apoptosis [IGI]
    regulation of epithelial cell differentiation [IMP]
    positive regulation of epithelial cell differentiation [IGI]
    negative regulation of epithelial cell proliferation [IGI][IMP]
    negative regulation of Wnt receptor signaling pathway [IGI][IMP]
    regulation of cell migration [IGI][IMP]
    positive regulation of cell migration [UNKNOWN][IMP]
    muscle cell homeostasis [IGI]
    negative regulation of MAPKKK cascade [IGI][IMP]
    negative regulation of cell proliferation [IGI][IMP]
    positive regulation of cell adhesion [IMP]
    regulation of osteoblast differentiation [IMP]
    thymus development [IMP]
    positive regulation of cell division [IMP]
    regulation of cell differentiation [IGI]
    cytokinesis after mitosis [UNKNOWN][IMP]
    regulation of osteoclast differentiation [IMP]
    negative regulation of odontogenesis [IMP]
    somatic stem cell maintenance [IGI][IMP]
    Wnt receptor signaling pathway through beta-catenin [IMP]
    cell migration [IMP]
    regulation of attachment of spindle microtubules to kinetochore [UNKNOWN][IMP]
    negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
    T cell differentiation in the thymus [IMP]
    neuron projection development [UNKNOWN]
    establishment or maintenance of cell polarity [UNKNOWN]
    positive regulation of cell differentiation [IMP]
    negative regulation of Wnt receptor signaling pathway through beta-catenin [UNKNOWN]
    chromosome organization [IGI][IMP]
    negative regulation of apoptosis [IMP]
    positive regulation of apoptosis [UNKNOWN][IMP]
    Molecular Function: protein binding [IPI]
    beta-catenin binding [IDA][IPI]
    binding [IEA]
    microtubule binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDETM  60
   61 TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS VSSRSGECSP VPMGSFPRRT 120
  121 FVNGSRESTG YLEELEKERS LLLADLDKEE KEKDWYYAQL QNLTKRIDSL PLTENFSLQT 180
  181 DMTRRQLEYE ARQIRAAMEE QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA 240
  241 ERSSQSRHDA ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR 300
  301 RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC LPLLIQLLHG 360
  361 NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR EIRVLHLLEQ IRAYCETCWE 420
  421 WQEAHEQGMD QDKNPMPAPV EHQICPAVCV LMKLSFDEEH RHAMNELGGL QAIAELLQVD 480
  481 CEMYGLTNDH YSVTLRRYAG MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ 540
  541 VIASVLRNLS WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN 600
  601 KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH RQILRENNCL 660
  661 QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG AVSMLKNLIH SKHKMIAMGS 720
  721 AAALRNLMAN RPAKYKDANI MSPGSSLPSL HVRKQKALEA ELDAQHLSET FDNIDNLSPK 780
  781 ASHRSKQRHK QNLYGDYAFD ANRHDDSRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD 840
  841 SSRSEKDRSL ERERGIGLSA YHPTTENAGT SSKRGLQITT TAAQIAKVME EVSAIHTSQD 900
  901 DRSSASTTEF HCVADDRSAA RRSSASHTHS NTYNFTKSEN SNRTCSMPYA KVEYKRSSND 960
  961 SLNSVTSSDG YGKRGQMKPS VESYSEDDES KFCSYGQYPA DLAHKIHSAN HMDDNDGELD1020
 1021 TPINYSLKYS DEQLNSGRQS PSQNERWARP KHVIEDEIKQ NEQRQARSQN TSYPVYSENT1080
 1081 DDKHLKFQPH FGQQECVSPY RSRGTSGSET NRMGSSHAIN QNVNQSLCQE DDYEDDKPTN1140
 1141 YSERYSEEEQ HEEEEERPTN YSIKYNEEKH HVDQPIDYSL KYATDISSSQ KPSFSFSKNS1200
 1201 SAQSTKPEHL SPSSENTAVP PSNAKRQNQL RPSSAQRNGQ TQKGTTCKVP SINQETIQTY1260
 1261 CVEDTPICFS RCSSLSSLSS ADDEIGCDQT TQEADSANTL QTAEVKENDV TRSAEDPATE1320
 1321 VPAVSQNARA KPSRLQASGL SSESTRHNKA VEFSSGAKSP SKSGAQTPKS PPEHYVQETP1380
 1381 LVFSRCTSVS SLDSFESRSI ASSVQSEPCS GMVSGIISPS DLPDSPGQTM PPSRSKTPPP1440
 1441 PPQTVQAKRE VPKSKVPAAE KRESGPKQTA VNAAVQRVQV LPDVDTLLHF ATESTPDGFS1500
 1501 CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNGNETESEQ PEESNENQDK EVEKPDSEKD1560
 1561 LLDDSDDDDI EILEECIISA MPTKSSRKAK KLAQTASKLP PPVARKPSQL PVYKLLPAQN1620
 1621 RLQAQKHVSF TPGDDVPRVY CVEGTPINFS TATSLSDLTI ESPPNELATG DGVRAGIQSG1680
 1681 EFEKRDTIPT EGRSTDDAQR GKISSIVTPD LDDNKAEEGD ILAECINSAM PKGKSHKPFR1740
 1741 VKKIMDQVQQ ASSTSSGANK NQVDTKKKKP TSPVKPMPQN TEYRTRVRKN TDSKVNVNTE1800
 1801 ETFSDNKDSK KPSLQTNAKA FNEKLPNNED RVRGTFALDS PHHYTPIEGT PYCFSRNDSL1860
 1861 SSLDFDDDDV DLSREKAELR KGKESKDSEA KVTCRPEPNS SQQAASKSQA SIKHPANRAQ1920
 1921 SKPVLQKQPT FPQSSKDGPD RGAATDEKLQ NLAIENTPVC FSRNSSLSSL SDIDQENNNN1980
 1981 KESEPIKEAE PANSQGEPSK PQASGYAPKS FHVEDTPVCF SRNSSLSSLS IDSEDDLLQE2040
 2041 CISSAMPKKK RPSRLKSESE KQSPRKVGGI LAEDLTLDLK DLQRPDSEHA FSPGSENFDW2100
 2101 KAIQEGANSI VSSLHQAAAA AACLSRQASS DSDSILSLKS GISLGSPFHL TPDQEEKPFT2160
 2161 SNKGPRILKP GEKSTLEAKK IESENKGIKG GKKVYKSLIT GKIRSNSEIS SQMKQPLPTN2220
 2221 MPSISRGRTM IHIPGLRNSS SSTSPVSKKG PPLKTPASKS PSEGPGATTS PRGTKPAGKS2280
 2281 ELSPITRQTS QISGSNKGSS RSGSRDSTPS RPTQQPLSRP MQSPGRNSIS PGRNGISPPN2340
 2341 KLSQLPRTSS PSTASTKSSG SGKMSYTSPG RQLSQQNLTK QASLSKNASS IPRSESASKG2400
 2401 LNQMSNGNGS NKKVELSRMS STKSSGSESD SSERPALVRQ STFIKEAPSP TLRRKLEESA2460
 2461 SFESLSPSSR PDSPTRSQAQ TPVLSPSLPD MSLSTHPSVQ AGGWRKLPPN LSPTIEYNDG2520
 2521 RPTKRHDIAR SHSESPSRLP INRAGTWKRE HSKHSSSLPR VSTWRRTGSS SSILSASSES2580
 2581 SEKAKSEDER HVSSMPAPRQ MKENQVPTKG TWRKIKESDI SPTGMASQSA SSGAASGAES2640
 2641 KPLIYQMAPP VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSVSEKG SSSIKDSKDS2700
 2701 KDTHGKQSVG SGSPVQTVGL ETRLNSFVQV EAPEQKGTEA KPGQSNPVSI AETAETCIAE2760
 2761 RTPFSSSSSS KHSSPSGTVA ARVTPFNYNP SPRKSSADST SARPSQIPTP VSTNTKKRDS2820
 2821 KTDITESSGA QSPKRHSGSY LVTSV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle