Protein Overview: SRBP1_RAT

General Information:
Name(s) found:	SRBP1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|166899085\|sp\|P56720.3\|SRBP1_RAT RecName: Full=Sterol regulatory element-binding protein 1; Short=SREBP-1; AltName: Full=Sterol regulatory element-binding transcription factor 1; AltName: Full=Adipocyte determination- and differentiation-dependent facto [NCBI NR] gi\|149052816\|gb\|EDM04633.1\| sterol regulatory element binding factor 1, isoform CRA_b [Rattus norvegicus] [NCBI NR] Sterol regulatory element-binding protein 1 OS=Rattus norvegicus GN=Srebf1 PE=1 SV=3 [Swiss-Prot] Tax_Id=10116 121 kDa protein [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1) (Adipocyte determination- and differentiation-dependent factor 1) (ADD1) [Contains: Processed sterol regulatory element-binding protein 1] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] sterol regulatory element binding factor 1, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Srebf1 Isoform SREBP-1A of Sterol regulatory element-binding protein 1 [rat-ipi-250309-contam.fasta] Isoform SREBP-1A of Sterol regulatory element-binding protein 1 OS=Rattus norvegicus GN=Srebf1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1134 amino acids
Gene Ontology:
Cellular Component:	endoplasmic reticulum membrane [IEA] nucleus [UNKNOWN][IDA][IEA] cytoplasm [UNKNOWN][IEA] ER to Golgi transport vesicle membrane [IEA] membrane [IEA] microsome [IDA] integral to membrane [IEA] cytoplasmic vesicle [IEA] Golgi membrane [IEA] endoplasmic reticulum [UNKNOWN][IEA] Golgi apparatus [IEA] protein complex [IDA]
Biological Process:	response to food [IEP] insulin receptor signaling pathway [UNKNOWN][IEA] positive regulation of histone deacetylation [UNKNOWN][IEA] response to progesterone stimulus [IEP] cholesterol metabolic process [IMP] steroid metabolic process [IEA] positive regulation of transcription [IMP] response to cAMP [IEP] positive regulation of cholesterol biosynthetic process [UNKNOWN][IEA] negative regulation of insulin secretion [UNKNOWN][IEA] regulation of transcription [UNKNOWN][IEA] positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA] negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA] cellular response to insulin stimulus [IEP] regulation of insulin secretion [UNKNOWN] response to glucose stimulus [UNKNOWN][IEA] response to retinoic acid [IEP] response to insulin stimulus [TAS] positive regulation of gene-specific transcription [IEA] response to lipid [IEP] response to fatty acid [IEP] lung development [IEP] regulation of heart rate by chemical signal [UNKNOWN][IEA] lipid biosynthetic process [TAS] cellular response to starvation [IDA] response to organic cyclic substance [IEP] aging [IEP] response to peptide hormone stimulus [IEP] positive regulation of triglyceride biosynthetic process [UNKNOWN][IEA] response to drug [IEP] response to glucagon stimulus [IEP] positive regulation of transcription via sterol regulatory element binding [UNKNOWN][IEA] regulation of fatty acid metabolic process [UNKNOWN][IEA]
Molecular Function:	DNA binding [UNKNOWN] transcription factor activity [UNKNOWN][ISS] protein binding [UNKNOWN] transcription regulator activity [IEA] specific RNA polymerase II transcription factor activity [IDA] sequence-specific DNA binding [IDA] chromatin binding [UNKNOWN][IDA][IEA] protein complex binding [IPI] sterol response element binding [UNKNOWN][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDELPFGEAA LEQALAEVCE MDAALLTDIE DMLQLINNQD SDFPGLFDAP YAGGETGDTG  60
   61 PSSPGASSPE SFSSPASLGS SLEAFLGGPK VTPAPLSPPP SAPTAVKMYP SVPPFSPGPG 120
  121 IKEEPVPLTI LQPPAPQPSP GTLLPPSFPP PPVQLSPAPV LGYSSLPSGF SGTLPGNTQQ 180
  181 TPSSLPLGST PGISPTPLHT QVQSSAAQQP PPASAAPRMS TVASQIQQVP VVLQPHFIKA 240
  241 DSLLLTAVKT DTGATMKTAG INTLAPGTAV QAGPLQTLVS GGTILATVPL VVDTDKLPIH 300
  301 RLAAGGKALG SAQSRGEKRT AHNAIEKRYR SSINDKIVEL KDLVVGTEAK LNKSAVLRKA 360
  361 IDYIRFLQHS NQKLKQENLT LRSAHKSKSL KDLVSACGSG GGTDVSMEGM KPEVVETLTP 420
  421 PPSDAGSPSQ SSPLSLGSRG SSSGGSDSEP DSPAFEDNQV KAQRLPSHSR GMLDRSRLAL 480
  481 CVLVFLCLTC NPLASLFGWG ILTPSDASGV HRSSGRSMLE AESRDGSNWT QWLLPPLVWL 540
  541 ANGLLVLACL ALLFVYGEPV TRPHSGPAVH FWRHRKQADL DLARGDFAQA AQQLWLALQA 600
  601 LGRPLPTSNL DLACSLLWNL VRHLLQRLWV GRWLAGQAGG LQRDYRLRKD ARASARDAAV 660
  661 VYHKLHQLHA MGKYTGGHLV ASNLALSALN LAECAGDAIS MATLAEIYVA AALRVKTSLP 720
  721 RALHFLTRFF LSSARQACLA QSGAVPLAMQ WLCHPVGHRF FVDGDWAVHG APQESLYSVA 780
  781 GNPVDPLAQV TRLFCEHLLE RALNCIAQPS PGAADGDREF SDALGYLQLL NSCSDAVGAP 840
  841 ACSFSVSSSM ATTTGTDPVA KWWASLTAVV IHWLRRDEEA AERLYPLVEH IPQVLQETER 900
  901 PLPRAALYSF KAARALLDHR KVESSPASLA ICEKASGYLR DSLASTSTAS SIDKAMQLLL 960
  961 CDLLLVARTS LWRRQQSAAS AQGAHGTSNG PQASALELRG FQHDLSSLRR LAQSFRPAMR1020
 1021 RVFLHEATAR LMAGASPART HQLLDRSLRR RAGSSGKGGA AAELEPRPTW REHTEALLLA1080
 1081 SCYLPPAFLS APGQRVSMLA EAARTVEKLG DHRLLLDCQQ MLLRLGGGTT VTSS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: SRBP1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: