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Protein Overview: UB2D1_RAT

General Information:
Name(s) found: UB2D1_RAT [Swiss-Prot]
Description(s) found:
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  • gi|157818361|ref|NP_001102000.1| ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog [Rattus norvegicus] [NCBI NR]
  • gi|149043805|gb|EDL97256.1| ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog (yeast) (predicted) [Rattus norvegicus] [NCBI NR]
  • gi|109509372|ref|XP_342126.3| PREDICTED: similar to ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog [Rattus norvegicus] [NCBI NR]
  • Ubiquitin-conjugating enzyme E2 D1 OS=Rattus norvegicus GN=Ube2d1 PE=1 SV=1 [Swiss-Prot]
  • ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog (yeast) (predicted) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • PREDICTED: similar to ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog [Rattus norvegicus] [nr-271106-contam.fasta]
  • Ubiquitin-conjugating enzyme E2 D1 OS=Rattus norvegicus GN=Ube2d1 [011711_HMR.fasta]
  • Isoform of D3ZDK2, Ubiquitin-conjugating enzyme E2 D1 OS=Rattus norvegicus GN=Ube2d1 PE=3 SV=2 [RAT.fasta.20160308]
    • Organism: Rattus norvegicus
    Length: 147 amino acids

    Gene Ontology:
    Cellular Component: cytosol [UNKNOWN]
    nucleoplasm [UNKNOWN]
    Biological Process: regulation of protein metabolic process [IEA]
    protein polyubiquitination [UNKNOWN]
    BMP signaling pathway [UNKNOWN]
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [UNKNOWN]
    positive regulation of protein ubiquitination [UNKNOWN]
    positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [UNKNOWN]
    post-translational protein modification [IEA]
    ubiquitin-dependent protein catabolic process [UNKNOWN]
    negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [UNKNOWN]
    Molecular Function: protein binding [UNKNOWN]
    small conjugating protein ligase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALKRIQKEL SDLQRDPPAH CSAGPVGDDL FHWQATIMGP PDSAYQGGVF FLTVHFPTDY  60
   61 PFKPPKIAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 120
  121 PDIAQIYKSD KEKYNRHARE WTQKYAM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] PSI-BLAST 55.522879 The 1.1A crystallographic structure of ubiquitin-conjugating enzyme (ubc-2) from Caenorhabditis elegans: functional and evolutionary significance

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.3486134076304 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.2964721480824 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.2401422444624 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  8.93602533934698 bayes_pls_golite062009
  • HLH domain binding
    		•  8.10904818707269 bayes_pls_golite062009
  • ligase activity
    		•  5.17219147802758 bayes_pls_golite062009
  • SUMO ligase activity
    		•  3.88357560284404 bayes_pls_golite062009
  • ISG15 ligase activity
    		•  3.37361650623694 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21355731489173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13970605403492 bayes_pls_golite062009
  • DNA binding
    		•  1.95596447916631 bayes_pls_golite062009
  • protein binding
    		•  1.77678273247394 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5236035191291 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19240180311941 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  0.715654744941217 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.122859425935324 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0104967529560147 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle