Protein Overview: IGF1R_MOUSE

General Information:
Name(s) found:	IGF1R_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|33859572\|ref\|NP_034643.1\| insulin-like growth factor I receptor [Mus musculus] [NCBI NR] gi\|3025894\|gb\|AAC12782.1\| insulin-like growth factor I receptor; IGF-I receptor [Mus musculus] [NCBI NR] gi\|187953037\|gb\|AAI38870.1\| Igf1r protein [Mus musculus] [NCBI NR] gi\|187951237\|gb\|AAI38869.1\| Igf1r protein [Mus musculus] [NCBI NR] gi\|12644455\|sp\|Q60751.3\|IGF1R_MOUSE RecName: Full=Insulin-like growth factor 1 receptor; AltName: Full=Insulin-like growth factor I receptor; Short=IGF-I receptor; AltName: CD_antigen=CD221; Contains: RecName: Full=Insulin-like growth factor 1 receptor al [NCBI NR] Insulin-like growth factor 1 receptor OS=Mus musculus GN=Igf1r PE=1 SV=3 [Swiss-Prot] (Q60751) Insulin-like growth factor I receptor precursor (EC 2.7.1.112) [Swiss-Prot] Ensembl_locations(Chr-bp):7-56081387;7-56081387 Insulin-like growth factor I receptor precursor [hmr_yeast5_DM3-1_pombe.fasta] insulin-like growth factor I receptor [HMR_022704-rand.fasta] Insulin-like growth factor I receptor precursor [ipi.MOUSE.v3.06.fasta] insulin-like growth factor I receptor [Mus musculus]gi\|12644455\|sp\|Q60751\|IG1R_MOUSE Insulin-like growth factor I receptor precursorgi\|3025894\|gb\|AAC12782.1\| insulin-like growth factor I receptor; IGF-I receptor [Mus musculus] [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Insulin-like growth factor 1 receptor precursor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] insulin-like growth factor I receptor [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Tax_Id=10090 Insulin-like growth factor I receptor precursor [EBI-IPI_mouse_3.06_05-10-2005_origrev_con.fasta] Insulin-like growth factor 1 receptor precursor (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Igf1r protein [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] insulin-like growth factor I receptor; IGF-I receptor [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 INSULIN-LIKE GROWTH FACTOR I RECEPTOR PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Igf1r Insulin-like growth factor 1 receptor [mouse-ipi-250309-contam.fasta] Tax_Id=10090 Gene_Symbol=Igf1r Insulin-like growth factor 1 receptor precursor [ipi.MOUSE_jw_12may08.contam.fasta] Tax_Id=10090 Gene_Symbol=Igf1r Insulin-like growth factor 1 receptor precursor ENSMUSG00000005533 IPI00120225 [IPIxENS.MOUSE_plus_REVERSE.fasta] IPI:IPI00120225.1\|SWISS-PROT:Q60751\|TREMBL:Q3U1L4;Q3UVJ3\|ENSEMBL:ENSMUSP00000005671\|REFSEQ:NP_034643 Tax_Id=10090 Gene_Symbol=Igf1r Insulin-like growth factor 1 receptor [ipi.MOUSE.fasta.20090209] Insulin-like growth factor 1 receptor OS=Mus musculus GN=Igf1r [011711_HMR.fasta] sp\|Q60751\|IGF1R_MOUSE Insulin-like growth factor 1 receptor OS=Mus musculus GN=Igf1r PE=1 SV=3 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	1373 amino acids
Gene Ontology:
Cellular Component:	caveola [UNKNOWN] membrane [IEA] integral to membrane [IEA] neuron projection [UNKNOWN] plasma membrane [IDA]
Biological Process:	prostate gland epithelium morphogenesis [IMP] negative regulation of MAPKKK cascade [IMP] neuron projection development [UNKNOWN] insulin-like growth factor receptor signaling pathway [IC] transmembrane receptor protein tyrosine kinase signaling pathway [IEA] protein amino acid autophosphorylation [IEA] auxin biosynthetic process [IEA] protein heterooligomerization [UNKNOWN] positive regulation of MAPKKK cascade [IMP] brain development [IMP] protein amino acid phosphorylation [IDA] positive regulation of anti-apoptosis [UNKNOWN] organ morphogenesis [IMP] male sex determination [IMP] mammary gland development [IMP] axonogenesis [UNKNOWN] positive regulation of DNA metabolic process [UNKNOWN] establishment of cell polarity [UNKNOWN] exocrine pancreas development [IMP] positive regulation of cytokinesis [UNKNOWN] positive regulation of protein kinase B signaling cascade [IMP] negative regulation of protein kinase B signaling cascade [IMP]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] protein tyrosine kinase activity [IEA] protein binding [IPI] metal ion binding [IEA] transmembrane receptor protein tyrosine kinase activity [IEA] insulin receptor substrate binding [UNKNOWN] protein kinase activity [IEA] transferase activity [IEA] receptor activity [IEA] kinase activity [IEA] insulin-like growth factor binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSGSGGGSP TSLWGLVFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGFLH  60
   61 ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF 120
  121 EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTIDWSLI LDAVSNNYIV GNKPPKECGD 180
  181 LCPGTLEEKP MCEKTTINNE YNYRCWTTNR CQKMCPSVCG KRACTENNEC CHPECLGSCH 240
  241 TPDDNTTCVA CRHYYYKGVC VPACPPGTYR FEGWRCVDRD FCANIPNAES SDSDGFVIHD 300
  301 DECMQECPSG FIRNSTQSMY CIPCEGPCPK VCGDEEKKTK TIDSVTSAQM LQGCTILKGN 360
  361 LLINIRRGNN IASELENFMG LIEVVTGYVK IRHSHALVSL SFLKNLRLIL GEEQLEGNYS 420
  421 FYVLDNQNLQ QLWDWNHRNL TVRSGKMYFA FNPKLCVSEI YRMEEVTGTK GRQSKGDINT 480
  481 RNNGERASCE SDVLRFTSTT TWKNRIIITW HRYRPPDYRD LISFTVYYKE APFKNVTEYD 540
  541 GQDACGSNSW NMVDVDLPPN KEGEPGILLH GLKPWTQYAV YVKAVTLTMV ENDHIRGAKS 600
  601 EILYIRTNAS VPSIPLDVLS ASNSSSQLIV KWNPPTLPNG NLSYYIVRWQ RQPQDGYLYR 660
  661 HNYCSKDKIP IRKYADGTID VEEVTENPKT EVCGGDKGPC CACPKTEAEK QAEKEEAEYR 720
  721 KVFENFLHNS IFVPRPERRR RDVMQVANTT MSSRSRNTTV ADTYNITDPE EFETEYPFFE 780
  781 SRVDNKERTV ISNLRPFTLY RIDIHSCNHE AEKLGCSASN FVFARTMPAE GADDIPGPVT 840
  841 WEPRPENSIF LKWPEPENPN GLILMYEIKY GSQVEDQREC VSRQEYRKYG GAKLNRLNPG 900
  901 NYTARIQATS LSGNGSWTDP VFFYVPAKTT YENFMHLIIA LPVAILLIVG GLVIMLYVFH 960
  961 RKRNNSRLGN GVLYASVNPE YFSAADVYVP DEWEVAREKI TMNRELGQGS FGMVYEGVAK1020
 1021 GVVKDEPETR VAIKTVNEAA SMRERIEFLN EASVMKEFNC HHVVRLLGVV SQGQPTLVIM1080
 1081 ELMTRGDLKS YLRSLRPEVE QNNLVLIPPS LSKMIQMAGE IADGMAYLNA NKFVHRDLAA1140
 1141 RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW MSPESLKDGV FTTHSDVWSF1200
 1201 GVVLWEIATL AEQPYQGLSN EQVLRFVMEG GLLDKPDNCP DMLFELMRMC WQYNPKMRPS1260
 1261 FLEIIGSIKD EMEPSFQEVS FYYSEENKPP EPEELEMELE MEPENMESVP LDPSASSASL1320
 1321 PLPERHSGHK AENGPGPGVL VLRASFDERQ PYAHMNGGRA NERALPLPQS STC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: IGF1R_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: