Protein Overview: Dscam-PAB

General Information:
Name(s) found:	Dscam-PAB / FBpp0110342 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|116007638\|ref\|NP_001036515.1\| down syndrome cell adhesion molecule, isoform AB [Drosophila melanogaster] [NCBI NR] gi\|113194620\|gb\|ABI31066.1\| down syndrome cell adhesion molecule, isoform AB [Drosophila melanogaster] [NCBI NR] The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase] type=protein; loc=2R:complement(3208188..3208269,3209088..3209154,3210065..3210223,3210281..3210461,3210527..3210837,3211324..3211473,3212087..3212242,3213657..3213869,3216794..3216960,3217018..3217194,3217248..3217356,3217422..3218105,3218164..3218319,32 [fly-100309-contam.fasta] Down syndrome cell adhesion molecule CG17800-PAB [Drosophila melanogaster] [nr-271106-contam.fasta] CG17800-PAB [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2R:complement(3208188..3208269,3209088..3209154,3210065..3210223,3210281..3210461,3210527..3210837,3211324..3211473,3212087..3212242,3213657..3213869,3216794..3216960,3217018..3217194,3217248..3217356,3217422..3218105,3218164..3218319,3218481..3219707,3219766..3219885,3227660..3227947,3235354..3235515,3235636..3236480,3242592..3242715,3249223..3249372,3252523..3252684,3255893..3256237,3265039..3265099); ID=FBpp0110342; name=Dscam-PAB; parent=FBgn0033159,FBtr0111050; dbxref=FlyBase:FBpp0110342,FlyBase_Annotation_IDs:CG17800-PAB,REFSEQ:NP_001036515,GB_protein:ABI31066; MD5=cb06ca64dcabf1ce321629ec22912510; length=2031; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2R:complement(3208188..3208269,3209088..3209154,3210065..3210223,3210281..3210461,3210527..3210837,3211324..3211473,3212087..3212242,3213657..3213869,3216794..3216960,3217018..3217194,3217248..3217356,3217422..3218105,3218164..3218319,3218481..3219707,3219766..3219885,3227660..3227947,3235354..3235515,3235636..3236480,3242592..3242715,3249223..3249372,3252523..3252684,3255893..3256237,3265039..3265099); ID=FBpp0110342; name=Dscam-PAB; parent=FBgn0033159,FBtr0111050; dbxref=FlyBase:FBpp0110342,FlyBase_Annotation_IDs:CG17800-PAB,REFSEQ:NP_001036515,GB_protein:ABI31066; MD5=cb06ca64dcabf1ce321629ec22912510; length=2031; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Down syndrome cell adhesion molecule, isoform AB OS=Drosophila melanogaster GN=Dscam PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2R:complement(3208188..3208269,3209088..3209154,3210065..3210223,3210281..3210461,3210527..3210837,3211324..3211473,3212087..3212242,3213657..3213869,3216794..3216960,3217018..3217194,3217248..3217356,3217422..3218105,3218164..3218319,3218481..3219707,3219766..3219885,3227660..3227947,3235354..3235515,3235636..3236480,3242592..3242715,3249223..3249372,3252523..3252684,3255893..3256237,3265039..3265099); ID=FBpp0110342; name=Dscam-PAB; parent=FBgn0033159,FBtr0111050; dbxref=FlyBase:FBpp0110342,FlyBase_Annotation_IDs:CG17800-PAB,REFSEQ:NP_001036515,GB_protein:ABI31066,FlyMine:FBpp0110342,modMine:FBpp0110342; MD5=cb06ca64dcabf1ce321629ec22912510; length=2031; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2R:complement(join(7377534..7377594,7368388..7368732,7365018..7365179,7361718..7361867,7355087..7355210,7348131..7348975,7347849..7348010,7340155..7340442,7332261..7332380,7330976..7332202,7330659..7330814,7329917..7330600,7329743..7329851,7329513..7329689,7329289..7329455,7326152..7326364,7324582..7324737,7323819..7323968,7323022..7323332,7322776..7322956,7322560..7322718,7321583..7321649,7320683..7320764)); ID=FBpp0110342; name=Dscam1-PAB; parent=FBgn0033159,FBtr0111050; dbxref=FlyBase:FBpp0110342,FlyBase_Annotation_IDs:CG17800-PAB,REFSEQ:NP_001036515,GB_protein:ABI31066,FlyMine:FBpp0110342,modMine:FBpp0110342; MD5=cb06ca64dcabf1ce321629ec22912510; length=2031; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:complement(join(7377534..7377594,7368388..7368732,7365018..7365179,7361718..7361867,7355087..7355210,7348131..7348975,7347849..7348010,7340155..7340442,7332261..7332380,7330976..7332202,7330659..7330814,7329917..7330600,7329743..7329851,7329513..7329689,7329289..7329455,7326152..7326364,7324582..7324737,7323819..7323968,7323022..7323332,7322776..7322956,7322560..7322718,7321583..7321649,7320683..7320764)); ID=FBpp0110342; name=Dscam1-PAB; parent=FBgn0033159,FBtr0111050; dbxref=FlyBase:FBpp0110342,FlyBase_Annotation_IDs:CG17800-PAB,REFSEQ:NP_001036515,GB_protein:ABI31066,FlyMine:FBpp0110342,modMine:FBpp0110342; MD5=cb06ca64dcabf1ce321629ec22912510; length=2031; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of A0A0B4K823, Down syndrome cell adhesion molecule 1, isoform AB OS=Drosophila melanogaster GN=Dscam1 PE=1 SV=1 [DROME.fasta.20160308] FBpp0110342 type=protein; loc=2R:complement(join(7377534..7377594,7368388..7368732,7365018..7365179,7361718..7361867,7355087..7355210,7348131..7348975,7347849..7348010,7340155..7340442,7332261..7332380,7330976..7332202,7330659..7330814,7329917..7330600,7329743..7329851,7329513..7329689,7329289..7329455,7326152..7326364,7324582..7324737,7323819..7323968,7323022..7323332,7322776..7322956,7322560..7322718,7321583..7321649,7320683..7320764)); ID=FBpp0110342; name=Dscam1-PAB; parent=FBgn0033159,FBtr0111050; dbxref=FlyBase:FBpp0110342,FlyBase_Annotation_IDs:CG17800-PAB,REFSEQ:NP_001036515,GB_protein:ABI31066,FlyMine:FBpp0110342,modMine:FBpp0110342; MD5=cb06ca64dcabf1ce321629ec22912510; length=2031; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2R:complement(join(7377534..7377594,7368388..7368732,7365018..7365179,7361718..7361867,7355087..7355210,7348131..7348975,7347849..7348010,7340155..7340442,7332261..7332380,7330976..7332202,7330659..7330814,7329917..7330600,7329743..7329851,7329513..7329689,7329289..7329455,7326152..7326364,7324582..7324737,7323819..7323968,7323022..7323332,7322776..7322956,7322560..7322718,7321583..7321649,7320683..7320764)); ID=FBpp0110342; name=Dscam1-PAB; parent=FBgn0033159,FBtr0111050; dbxref=FlyBase:FBpp0110342,FlyBase_Annotation_IDs:CG17800-PAB,REFSEQ:NP_001036515,GB_protein:ABI31066,UniProt/TrEMBL:Q0E9J4,FlyMine:FBpp0110342,modMine:FBpp0110342; MD5=cb06ca64dcabf1ce321629ec22912510; length=2031; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2031 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [ISS] dendrite [IDA] neuronal cell body [IDA] axon [IDA]
Biological Process:	mushroom body development [IMP] dendrite self-avoidance [IDA][IMP] phagocytosis [IMP] axon guidance [IGI][IMP][TAS] peripheral nervous system development [IMP] neuron development [IMP] central nervous system morphogenesis [IMP] axonal fasciculation [IMP] axon extension involved in axon guidance [IMP]
Molecular Function:	protein binding [IDA] protein homodimerization activity [IPI] axon guidance receptor activity [IMP][NAS] bacterial cell surface binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVNQY YEAEVVSEYV IRGNTAVLKC TIPSFVADFL RVEAWVASDG 180
  181 TEYAPEEDFD GKYLVLPSGE LHIREVGPED GYKSYQCRTK HRLTGETRLS ATKGRLVITE 240
  241 PVGSVGPKIS VGERLRDAGA PSKSTLTLFC PAQSYPVPSF RWYKFIEGTT RKQAVVLNDR 300
  301 VKQVSGTLII KDAVVEDSGK YLCVVNNSVG GESVETVLTV TAPLSAKIDP PTQTVDFGRP 360
  361 AVFTCQYTGN PIKTVSWMKD GKAIGHSEPV LRIESVKKED KGMYQCFVRN DQESAEASAE 420
  421 LKLGGRFDPP VIRQAFQEET MEPGPSVFLK CVAGGNPTPE ISWELDGKKI ANNDRYQVGQ 480
  481 YVTVNGDVVS YLNITSVHAN DGGLYKCIAK SKVGVAEHSA KLNVYGLPYI RQMEKKAIVA 540
  541 GETLIVTCPV AGYPIDSIVW ERDNRALPIN RKQKVFPNGT LIIENVERNS DQATYTCVAK 600
  601 NQEGYSARGS LEVQVMAPPK ITPFSFGEEP ANVEDSVSVT CLISTGDLPI DIEWFFNEYG 660
  661 ISSYSGISVM KGGKRNSVLS IDSVQARHAG NYSCRAKNHA AAVNYTTDLI VNVPPRWILE 720
  721 PTDKAFAQGS DAKVECKADG FPKPQVTWKK AVGDTPGEYK DLKKSDNIRV EEGTLHVDNI 780
  781 QKTNEGYYLC EAINGIGSGL SAVIMISVQA PPEFTEKLRN QTARRGEPAV LQCEAKGEKP 840
  841 IGILWNMNNM RLDPKNDNRY TIREEILSTG VMSSLSIKRT ERSDSALFTC VATNAFGSDD 900
  901 ASINMIVQEV PEMPYALKVL DKSGRSVQLS WAQPYDGNSP LDRYIIEFKR SRASWSEIDR 960
  961 VIVPGHTTEA QVQKLSPATT YNIRIVAENA IGTSQSSEAV TIITAEEAPS GKPQNIKVEP1020
 1021 VNQTTMRVTW KPPPRTEWNG EILGYYVGYK LSNTNSSYVF ETINFITEEG KEHNLELQNL1080
 1081 RVYTQYSVVI QAFNKIGAGP LSEEEKQFTA EGTPSQPPSD TACTTLTSQT IRVGWVSPPL1140
 1141 ESANGVIKTY KVVYAPSDEW YDETKRHYKK TASSDTVLHG LKKYTNYTMQ VLATTAGGDG1200
 1201 VRSVPIHCQT EPDVPEAPTD VKALVMGNAA ILVSWRPPAQ PNGIITQYTV YSKAEGAETE1260
 1261 TKTQKVPHYQ MSFEATELEK NKPYEFWVTA STTIGEGQQS KSIVAMPSDQ VPAKIASFDD1320
 1321 TFTATFKEDA KMPCLAVGAP QPEITWKIKG VEFSANDRMR VLPDGSLLIK SVNRQDAGDY1380
 1381 SCHAENSIAK DSITHKLIVL APPQSPHVTL SATTTDALTV KLKPHEGDTA PLHGYTLHYK1440
 1441 PEFGEWETSE VSVDSQKHNI EGLLCGSRYQ VYATGFNNIG AGEASDILNT RTKGQKPKLP1500
 1501 EKPRFIEVSS NSVSLHFKAW KDGGCPMSHF VVESKKRDQI EWNQISNNVK PDNNYVVLDL1560
 1561 EPATWYNLRI TAHNSAGFTV AEYDFATLTV TGGTIAPLDD GSGHGNVHTR IRLPAWMPEW1620
 1621 LDLNFMVPLI ATVVVVAVGI CVVCVALSRR RADDMRGGQK DVYYDVVYNQ TMGPGATLDK1680
 1681 RRPDLRDELG YIAPPNRKLP PVPGSNYNTC DRIKRGRGGL RSNHSTWDPR RNPNLYEELK1740
 1741 APPVPMHGNH YGHAHGNAEC HYRHPGMEDE ICPYATFHLL GFREEMDPTK AMNFQTFPHQ1800
 1801 NGHAGPVPGH AGTMLPPGHP GHVHSRSGSQ SMPRANRYQR KNSQGGQSSI YTPAPEYDDP1860
 1861 ANCAEEDQYR RYTRVNSQGG SLYSGPGPEY DDPANCAPEE DQYGSQYGGP YGQPYDHYGS1920
 1921 RGSMGRRSIG SARNPGNGSP EPPPPPPRNH DMSNSSFNDS KESNEISEAE CDRDHGPRGN1980
 1981 YGAVKRSPQP KDQRTTEEMR KLIERNETGP KQLQLQQANG AGFTAYDTMA V

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..137]	PSI-BLAST	79.09691	No description for 2v5sA was found.
2	View Details	[138..810]	PSI-BLAST	60.522879	Model of human carcinoembryonic antigen by homology modelling and curve-fitting to experimental solution scattering data
3	View Details	[811..1349]	PSI-BLAST	26.69897	No description for 2v5yA was found.
4	View Details	[1350..1481]	PSI-BLAST	34.0	No description for 2nziA was found.
5	View Details	[1482..1603]	PSI-BLAST	11.39794	The solution structure of the sixth fibronectin type III domain of human Neogenin
6	View Details	[1604..1784]	deduced	N/A	No confident structure predictions are available.
7	View Details	[1785..2031]	MSA	1.112993	View MSA. No confident structure predictions are available.

Protein Overview: Dscam-PAB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: