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Protein Overview: MSX3_MOUSE

General Information:
Name(s) found: MSX3_MOUSE [Swiss-Prot]
Description(s) found:
Found 31 descriptions.
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  • Homeobox protein MSX-3 OS=Mus musculus GN=Msx3 PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 204 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IDA][IGI]
    negative regulation of histone acetylation [IGI]
    transcription [IEA]
    multicellular organismal development [IEA]
    regulation of transcription, DNA-dependent [IEA]
    regulation of transcription [IEA]
    regulation of transcription from RNA polymerase II promoter [IDA]
    Molecular Function: DNA binding [IEA]
    transcription factor activity [IEA]
    protein binding [IPI]
    transcription regulator activity [IEA]
    sequence-specific DNA binding [IEA]
    specific transcriptional repressor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARATFDMNA AGLEARGGGH TEHGPLPFSV ESLLEAERVP GSESGELGVE RPLGASKPGA  60
   61 WPPPVAHSCP PRAPSPPPCT LRKHKTNRKP RTPFTTAQLL ALERKFHQKQ YLSIAERAEF 120
  121 SSSLSLTETQ VKIWFQNRRA KAKRLQEAEL EKLKLAAKPL LPAAFALPFP LGTQLHSSAA 180
  181 TFGGNAVPGI LAGPVAAYGM YYLS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..204] PSI-BLAST 26.69897 Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.55154985983449 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.49423102874486 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.41914532284031 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.41914532284031 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • histone binding
    		•  0.557787598121402 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.354455864390293 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.141579851073927 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.141400887946529 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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