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View Structure Prediction Details

Protein: MSX3_MOUSE
Organism: Mus musculus
Length: 204 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSX3_MOUSE.

Description E-value Query
Range
Subject
Range
gi|786328 - gi|786328|gb|AAB32671.1| Pax-6 [Rattus sp.]
gi|480038, gi|446399 - gi|480038|pir||S36166 paired box transcription factor Pax-6 - rat (fragment), gi|446399|prf||1911405...
133.0 [0..26] [163..56]
gi|30704771 - gi|30704771|gb|AAH51983.1| Msx3 protein [Mus musculus]
131.0 [0..1] [204..20]
gi|47222353 - gi|47222353|emb|CAG05102.1| unnamed protein product [Tetraodon nigroviridis]
130.0 [0..3] [194..70]
gi|1334651 - gi|1334651|emb|CAA30124.1| unnamed protein product [Xenopus laevis]
127.0 [0..85] [163..1]
gi|34419191 - gi|34419191|dbj|BAC84954.1| homeobox protein Chx10-1 [Cynops pyrrhogaster]
125.0 [0..24] [198..87]
gi|5441871 - gi|5441871|dbj|BAA82371.1| Hoxb-5 [Paralichthys olivaceus]
125.0 [0..79] [162..3]
gi|745777, gi|52... - gi|745777|prf||2016458D Hox-5 gene, gi|520614|emb|CAA84517.1| Hox-5 homeodomain protein [Branchiosto...
124.0 [0..82] [164..1]
gi|68389607 - gi|68389607|ref|XP_693830.1| PREDICTED: similar to cartilage homeo protein 1 [Danio rerio]
124.0 [0..12] [202..130]

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Predicted Domain #1
Region A:
Residues: [1-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARATFDMNA AGLEARGGGH TEHGPLPFSV ESLLEAERVP GSESGELGVE RPLGASKPGA  60
   61 WPPPVAHSCP PRAPSPPPCT LRKHKTNRKP RTPFTTAQLL ALERKFHQKQ YLSIAERAEF 120
  121 SSSLSLTETQ VKIWFQNRRA KAKRLQEAEL EKLKLAAKPL LPAAFALPFP LGTQLHSSAA 180
  181 TFGGNAVPGI LAGPVAAYGM YYLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1pufA
Description: Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
transcription repressor activity 3.55154985983449 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription corepressor activity 1.49423102874486 bayes_pls_golite062009
histone acetyltransferase activity 1.41914532284031 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.41914532284031 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
histone binding 0.557787598121402 bayes_pls_golite062009
N-acyltransferase activity 0.354455864390293 bayes_pls_golite062009
N-acetyltransferase activity 0.141579851073927 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.141400887946529 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle