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Protein Overview: TLL1

General Information:
Name(s) found: TLL1 [HGNC (HUGO)]
Description(s) found:
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  • gi|74762106|sp|O43897.1|TLL1_HUMAN RecName: Full=Tolloid-like protein 1; Flags: Precursor [NCBI NR]
  • gi|2735327|gb|AAB93878.1| tolloid-like protein [Homo sapiens] [NCBI NR]
  • gi|22547221|ref|NP_036596.3| tolloid-like 1 [Homo sapiens] [NCBI NR]
  • gi|223460108|gb|AAI36430.1| Tolloid-like 1 [Homo sapiens] [NCBI NR]
  • gi|187950349|gb|AAI36431.1| Tolloid-like 1 [Homo sapiens] [NCBI NR]
  • gi|119625218|gb|EAX04813.1| tolloid-like 1 [Homo sapiens] [NCBI NR]
  • tolloid-like 1 [HGNC (HUGO)]
  • Tolloid-like protein 1 OS=Homo sapiens GN=TLL1 PE=1 SV=1 [Swiss-Prot]
  • Tolloid-like protein [hmr_yeast5_DM3-1_pombe.fasta]
  • tolloid-like 1 [Homo sapiens]gi|2735327|gb|AAB93878.1| tolloid-like protein [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Splice Isoform 1 of Tolloid-like protein 1 precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • tolloid-like 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Tolloid-like protein [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • Tolloid-like protein 1 precursor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tolloid-like 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • tolloid-like protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Tolloid-like protein 1 precursor [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 TOLLOID-LIKE PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Tolloid-like protein 1; Flags: Precursor [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=TLL1 Isoform 1 of Tolloid-like protein 1 [human-ipi-250309-contam.fasta]
  • tolloid-like 1 precursor [Homo sapiens] [NCBI-RefSeq_human_na_10-19-2009_con_reversed.fasta]
  • IPI:IPI00018381.1|SWISS-PROT:O43897-1|TREMBL:B2RMU2|ENSEMBL:ENSP00000061240|REFSEQ:NP_036596|H-INV:HIT000222598 Tax_Id=9606 Gene_Symbol=TLL1 Isoform 1 of Tolloid-like protein 1 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=TLL1 Isoform 1 of Tolloid-like protein 1 precursor ENSG00000038295 IPI00018381 IPI00718863 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=TLL1 Isoform 1 of Tolloid-like protein 1 precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • tolloid-like protein 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • O43897;B2RMU2;Q96AN3;Q9NQS4; RecName: Full=Tolloid-like protein 1; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Tolloid-like protein 1 OS=Homo sapiens GN=TLL1 [011711_HMR.fasta]
  • IPI:IPI00018381.1|SWISS-PROT:O43897-1|ENSEMBL:ENSP00000061240|REFSEQ:NP_036596|H-INV:HIT000222598 Tax_Id=9606 Gene_Symbol=TLL1 Isoform 1 of Tolloid-like protein 1 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=TLL1 Synonyms=ASD6|TLL tolloid-like protein 1 precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00018381.1|SWISS-PROT:O43897-1|ENSEMBL:ENSP00000061240|REFSEQ:NP_036596|H-INV:HIT000222598|VEGA:OTTHUMP00000219730 Tax_Id=9606 Gene_Symbol=TLL1 Isoform 1 of Tolloid-like protein 1 [ipi.HUMAN.20110912.fasta]
  • Tolloid-like protein 1 GN=TLL1 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 1013 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLGTLSPRM LVWLVASGIV FYGELWVCAG LDYDYTFDGN EEDKTETIDY KDPCKAAVFW  60
   61 GDIALDDEDL NIFQIDRTID LTQNPFGNLG HTTGGLGDHA MSKKRGALYQ LIDRIRRIGF 120
  121 GLEQNNTVKG KVPLQFSGQN EKNRVPRAAT SRTERIWPGG VIPYVIGGNF TGSQRAMFKQ 180
  181 AMRHWEKHTC VTFIERSDEE SYIVFTYRPC GCCSYVGRRG NGPQAISIGK NCDKFGIVVH 240
  241 ELGHVIGFWH EHTRPDRDNH VTIIRENIQP GQEYNFLKME PGEVNSLGER YDFDSIMHYA 300
  301 RNTFSRGMFL DTILPSRDDN GIRPAIGQRT RLSKGDIAQA RKLYRCPACG ETLQESNGNL 360
  361 SSPGFPNGYP SYTHCIWRVS VTPGEKIVLN FTTMDLYKSS LCWYDYIEVR DGYWRKSPLL 420
  421 GRFCGDKLPE VLTSTDSRMW IEFRSSSNWV GKGFAAVYEA ICGGEIRKNE GQIQSPNYPD 480
  481 DYRPMKECVW KITVSESYHV GLTFQSFEIE RHDNCAYDYL EVRDGTSENS PLIGRFCGYD 540
  541 KPEDIRSTSN TLWMKFVSDG TVNKAGFAAN FFKEEDECAK PDRGGCEQRC LNTLGSYQCA 600
  601 CEPGYELGPD RRSCEAACGG LLTKLNGTIT TPGWPKEYPP NKNCVWQVVA PTQYRISVKF 660
  661 EFFELEGNEV CKYDYVEIWS GLSSESKLHG KFCGAEVPEV ITSQFNNMRI EFKSDNTVSK 720
  721 KGFKAHFFSD KDECSKDNGG CQHECVNTMG SYMCQCRNGF VLHDNKHDCK EAECEQKIHS 780
  781 PSGLITSPNW PDKYPSRKEC TWEISATPGH RIKLAFSEFE IEQHQECAYD HLEVFDGETE 840
  841 KSPILGRLCG NKIPDPLVAT GNKMFVRFVS DASVQRKGFQ ATHSTECGGR LKAESKPRDL 900
  901 YSHAQFGDNN YPGQVDCEWL LVSERGSRLE LSFQTFEVEE EADCGYDYVE LFDGLDSTAV 960
  961 GLGRFCGSGP PEEIYSIGDS VLIHFHTDDT INKKGFHIRY KSIRYPDTTH TKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] deduced N/A No confident structure predictions are available.
    2 View Details [107..361] PSI-BLAST 40.69897 STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
    3 View Details [362..769] PSI-BLAST 13.69897 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    4 View Details [770..874] PSI-BLAST 31.0 Mannose-binding protein associated serine protease 2, MASP2
    5 View Details [875..1013] PSI-BLAST 4.39794 CRYSTAL STRUCTURE OF ACIDIC SEMINAL FLUID PROTEIN (ASFP) AT 1.9 A RESOLUTION: A BOVINE POLYPEPTIDE FROM THE SPERMADHESIN FAMILY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  5.33358263548929 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.99457783001146 bayes_pls_golite062009
  • endopeptidase activity
    		•  4.16532996235931 bayes_pls_golite062009
  • metallopeptidase activity
    		•  3.94798058866011 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  3.43236442601127 bayes_pls_golite062009
  • integrin binding
    		•  2.88756686973769 bayes_pls_golite062009
  • hydrolase activity
    		•  2.63109625301237 bayes_pls_golite062009
  • exopeptidase activity
    		•  2.07461908743946 bayes_pls_golite062009
  • receptor binding
    		•  2.07222569254168 bayes_pls_golite062009
  • protein binding
    		•  1.74238091923401 bayes_pls_golite062009
  • binding
    		•  1.55761777216628 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.994405248731328 bayes_pls_golite062009
  • catalytic activity
    		•  0.891187593353827 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.61233964043845 bayes_pls_golite062009
  • zinc ion binding
    		•  0.49304764842799 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.489265029264191 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.46452174183235 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.393080846858665 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.374597710524442 bayes_pls_golite062009
  • heparin binding
    		•  0.33626934218604 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  0.286312555161631 bayes_pls_golite062009
  • peptidyl-dipeptidase activity
    		•  0.27229268642689 bayes_pls_golite062009
  • growth factor activity
    		•  0.259654587796416 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  0.252655558968584 bayes_pls_golite062009
    3
    Term Confidence Notes
  • receptor binding
    		•  4.33045214660893 bayes_pls_golite062009
  • growth factor activity
    		•  3.53240291240997 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  3.49243532917035 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  3.33042410578504 bayes_pls_golite062009
  • protein binding
    		•  3.1871213817468 bayes_pls_golite062009
  • heparin binding
    		•  3.0535264040722 bayes_pls_golite062009
  • polysaccharide binding
    		•  2.79319890241656 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  2.60188936442106 bayes_pls_golite062009
  • binding
    		•  2.54996368217395 bayes_pls_golite062009
  • pattern binding
    		•  1.7855850180475 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.883503304213219 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.847169032980225 bayes_pls_golite062009
  • transcription factor binding
    		•  0.73345647755411 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.65375278435874 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  0.65339109098708 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.37481112933019 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.230499048015879 bayes_pls_golite062009
    4
    Term Confidence Notes
  • peptidase activity
    		•  3.17967257091654 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.2470239332285 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.22068546360893 bayes_pls_golite062009
  • protein binding
    		•  1.66454811956715 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  1.39151268274571 bayes_pls_golite062009
  • binding
    		•  1.35566487950264 bayes_pls_golite062009
  • metallopeptidase activity
    		•  1.34388258592372 bayes_pls_golite062009
  • hydrolase activity
    		•  0.970440417433029 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.144877066449329 bayes_pls_golite062009
  • receptor activity
    		•  0.125459063751662 bayes_pls_golite062009
  • catalytic activity
    		•  0.075748351866431 bayes_pls_golite062009
    5
    Term Confidence Notes
  • peptidase activity
    		•  3.17967257091654 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.2470239332285 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.22068546360893 bayes_pls_golite062009
  • protein binding
    		•  1.66454811956715 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  1.39151268274571 bayes_pls_golite062009
  • binding
    		•  1.35566487950264 bayes_pls_golite062009
  • metallopeptidase activity
    		•  1.34388258592372 bayes_pls_golite062009
  • hydrolase activity
    		•  0.970440417433029 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.144877066449329 bayes_pls_golite062009
  • receptor activity
    		•  0.125459063751662 bayes_pls_golite062009
  • catalytic activity
    		•  0.075748351866431 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle