Protein Overview: USP11

General Information:
Name(s) found:	USP11 [HGNC (HUGO)]
Description(s) found: Found 27 descriptions. SHOW ALL	ubiquitin specific peptidase 11 [HGNC (HUGO)]
Organism:	Homo sapiens
Length:	963 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVAPRLFGG LCFRFRDQNP EVAVEGRLPI SHSCVGCRRE RTAMATVAAN PAAAAAAVAA  60
   61 AAAVTEDREP QHEELPGLDS QWRQIENGES GRERPLRAGE SWFLVEKHWY KQWEAYVQGG 120
  121 DQDSSTFPGC INNATLFQDE INWRLKEGLV EGEDYVLLPA AAWHYLVSWY GLEHGQPPIE 180
  181 RKVIELPNIQ KVEVYPVELL LVRHNDLGKS HTVQFSHTDS IGLVLRTARE RFLVEPQEDT 240
  241 RLWAKNSEGS LDRLYDTHIT VLDAALETGQ LIIMETRKKD GTWPSAQLHV MNNNMSEEDE 300
  301 DFKGQPGICG LTNLGNTCFM NSALQCLSNV PQLTEYFLNN CYLEELNFRN PLGMKGEIAE 360
  361 AYADLVKQAW SGHHRSIVPH VFKNKVGHFA SQFLGYQQHD SQELLSFLLD GLHEDLNRVK 420
  421 KKEYVELCDA AGRPDQEVAQ EAWQNHKRRN DSVIVDTFHG LFKSTLVCPD CGNVSVTFDP 480
  481 FCYLSVPLPI SHKRVLEVFF IPMDPRRKPE QHRLVVPKKG KISDLCVALS KHTGISPERM 540
  541 MVADVFSHRF YKLYQLEEPL SSILDRDDIF VYEVSGRIEA IEGSREDIVV PVYLRERTPA 600
  601 RDYNNSYYGL MLFGHPLLVS VPRDRFTWEG LYNVLMYRLS RYVTKPNSDD EDDGDEKEDD 660
  661 EEDKDDVPGP STGGSLRDPE PEQAGPSSGV TNRCPFLLDN CLGTSQWPPR RRRKQLFTLQ 720
  721 TVNSNGTSDR TTSPEEVHAQ PYIAIDWEPE MKKRYYDEVE AEGYVKHDCV GYVMKKAPVR 780
  781 LQECIELFTT VETLEKENPW YCPSCKQHQL ATKKLDLWML PEILIIHLKR FSYTKFSREK 840
  841 LDTLVEFPIR DLDFSEFVIQ PQNESNPELY KYDLIAVSNH YGGMRDGHYT TFACNKDSGQ 900
  901 WHYFDDNSVS PVNENQIESK AAYVLFYQRQ DVARRLLSPA GSSGAPASPA CSSPPSSEFM 960
  961 DVN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	None Entered	Sample pIC145 from april 2005	Okada, M., et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..187]	PSI-BLAST	30.39794	Solution structure of the DUSP domain of hUSP15
2	View Details	[188..289]	FFAS03	1.51	Solution Structure of the Ubiquitin-like Domain from Mouse Hypothetical 1700011N24Rik Protein
3	View Details	[290..657]	PSI-BLAST	61.0	No description for 2gfoA was found.
4	View Details	[658..963]	PSI-BLAST	40.045757	Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
peptidase activity	3.69173405245576	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.43109370848144	bayes_pls_golite062009
endopeptidase activity	2.75397594334424	bayes_pls_golite062009
hydrolase activity	2.73447072772242	bayes_pls_golite062009
binding	2.43973746940455	bayes_pls_golite062009
cysteine-type peptidase activity	2.03076448806511	bayes_pls_golite062009
cysteine-type endopeptidase activity	1.33423779714503	bayes_pls_golite062009
protein binding	1.14776614585261	bayes_pls_golite062009
small conjugating protein-specific protease activity	0.95030254676609	bayes_pls_golite062009
ubiquitin-specific protease activity	0.72977635292048	bayes_pls_golite062009
catalytic activity	0.639120026974844	bayes_pls_golite062009

2

Term	Confidence	Notes
binding	2.11588141989606	bayes_pls_golite062009
hydrolase activity	1.71270780201188	bayes_pls_golite062009
small conjugating protein ligase activity	1.64626529520014	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.03640529353043	bayes_pls_golite062009
protein binding	1.03325409251792	bayes_pls_golite062009
acid-amino acid ligase activity	0.778769490362734	bayes_pls_golite062009
nucleic acid binding	0.406724367405638	bayes_pls_golite062009
DNA binding	0.102021710653816	bayes_pls_golite062009
transcription regulator activity	0.0672274772804511	bayes_pls_golite062009

3

No functions predicted.

4

Term	Confidence	Notes
peptidase activity	4.81781093386823	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	4.44809261178642	bayes_pls_golite062009
hydrolase activity	3.74079711298952	bayes_pls_golite062009
endopeptidase activity	3.37014194828197	bayes_pls_golite062009
cysteine-type peptidase activity	3.05412701733177	bayes_pls_golite062009
cysteine-type endopeptidase activity	1.95802900199539	bayes_pls_golite062009
ubiquitin thiolesterase activity	1.71956723967893	bayes_pls_golite062009
binding	1.3276268995308	bayes_pls_golite062009
small conjugating protein-specific protease activity	1.16758945018031	bayes_pls_golite062009
catalytic activity	1.05972260874031	bayes_pls_golite062009
thiolester hydrolase activity	0.86592833690416	bayes_pls_golite062009
ubiquitin-specific protease activity	0.495368836247989	bayes_pls_golite062009
nucleic acid binding	0.439226369799415	bayes_pls_golite062009
kininogen binding	0.41283715939055	bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity	0.196538841514154	bayes_pls_golite062009
protein binding	0.177568040298733	bayes_pls_golite062009
DNA binding	0.168761518285256	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.56

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle