YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: USP11
Organism: Homo sapiens
Length: 963 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for USP11.

Description E-value Query
Range
Subject
Range
gi|109130539 - gi|109130539|ref|XP_001093504.1| PREDICTED: similar to ubiquitin specific protease 11 isoform 4 [Mac...
0.0 [1..963] [1..963]
gi|55727816|emb|... - hypothetical protein [Pongo pygmaeus]
gi|55727816 - gi|55727816|emb|CAH90661.1| hypothetical protein [Pongo abelii]
0.0 [33..963] [1..931]
gi|39795322 - gi|39795322|gb|AAH63668.1| USP11 protein [Homo sapiens]
0.0 [65..963] [25..923]
gi|76655800 - gi|76655800|ref|XP_583852.2| PREDICTED: similar to ubiquitin specific protease 11 isoform 1 [Bos tau...
0.0 [1..963] [1..952]
UBP11_RAT - Ubiquitin carboxyl-terminal hydrolase 11 OS=Rattus norvegicus GN=Usp11 PE=1 SV=1
0.0 [66..963] [18..921]

Back

Predicted Domain #1
Region A:
Residues: [1-187]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVAPRLFGG LCFRFRDQNP EVAVEGRLPI SHSCVGCRRE RTAMATVAAN PAAAAAAVAA  60
   61 AAAVTEDREP QHEELPGLDS QWRQIENGES GRERPLRAGE SWFLVEKHWY KQWEAYVQGG 120
  121 DQDSSTFPGC INNATLFQDE INWRLKEGLV EGEDYVLLPA AAWHYLVSWY GLEHGQPPIE 180
  181 RKVIELP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 30.39794
Match: 1w6vA
Description: Solution structure of the DUSP domain of hUSP15
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.69173405245576 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.43109370848144 bayes_pls_golite062009
endopeptidase activity 2.75397594334424 bayes_pls_golite062009
hydrolase activity 2.73447072772242 bayes_pls_golite062009
binding 2.43973746940455 bayes_pls_golite062009
cysteine-type peptidase activity 2.03076448806511 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.33423779714503 bayes_pls_golite062009
protein binding 1.14776614585261 bayes_pls_golite062009
small conjugating protein-specific protease activity 0.95030254676609 bayes_pls_golite062009
ubiquitin-specific protease activity 0.72977635292048 bayes_pls_golite062009
catalytic activity 0.639120026974844 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [188-289]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIQKVEVYPV ELLLVRHNDL GKSHTVQFSH TDSIGLVLRT ARERFLVEPQ EDTRLWAKNS  60
   61 EGSLDRLYDT HITVLDAALE TGQLIIMETR KKDGTWPSAQ LH

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.51
Match: 1v5oA
Description: Solution Structure of the Ubiquitin-like Domain from Mouse Hypothetical 1700011N24Rik Protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.11588141989606 bayes_pls_golite062009
hydrolase activity 1.71270780201188 bayes_pls_golite062009
small conjugating protein ligase activity 1.64626529520014 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.03640529353043 bayes_pls_golite062009
protein binding 1.03325409251792 bayes_pls_golite062009
acid-amino acid ligase activity 0.778769490362734 bayes_pls_golite062009
nucleic acid binding 0.406724367405638 bayes_pls_golite062009
DNA binding 0.102021710653816 bayes_pls_golite062009
transcription regulator activity 0.0672274772804511 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [290-657]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VMNNNMSEED EDFKGQPGIC GLTNLGNTCF MNSALQCLSN VPQLTEYFLN NCYLEELNFR  60
   61 NPLGMKGEIA EAYADLVKQA WSGHHRSIVP HVFKNKVGHF ASQFLGYQQH DSQELLSFLL 120
  121 DGLHEDLNRV KKKEYVELCD AAGRPDQEVA QEAWQNHKRR NDSVIVDTFH GLFKSTLVCP 180
  181 DCGNVSVTFD PFCYLSVPLP ISHKRVLEVF FIPMDPRRKP EQHRLVVPKK GKISDLCVAL 240
  241 SKHTGISPER MMVADVFSHR FYKLYQLEEP LSSILDRDDI FVYEVSGRIE AIEGSREDIV 300
  301 VPVYLRERTP ARDYNNSYYG LMLFGHPLLV SVPRDRFTWE GLYNVLMYRL SRYVTKPNSD 360
  361 DEDDGDEK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.0
Match: 2gfoA
Description: No description for 2gfoA was found.

Predicted Domain #4
Region A:
Residues: [658-963]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDDEEDKDDV PGPSTGGSLR DPEPEQAGPS SGVTNRCPFL LDNCLGTSQW PPRRRRKQLF  60
   61 TLQTVNSNGT SDRTTSPEEV HAQPYIAIDW EPEMKKRYYD EVEAEGYVKH DCVGYVMKKA 120
  121 PVRLQECIEL FTTVETLEKE NPWYCPSCKQ HQLATKKLDL WMLPEILIIH LKRFSYTKFS 180
  181 REKLDTLVEF PIRDLDFSEF VIQPQNESNP ELYKYDLIAV SNHYGGMRDG HYTTFACNKD 240
  241 SGQWHYFDDN SVSPVNENQI ESKAAYVLFY QRQDVARRLL SPAGSSGAPA SPACSSPPSS 300
  301 EFMDVN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.045757
Match: 1nb8A
Description: Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.81781093386823 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.44809261178642 bayes_pls_golite062009
hydrolase activity 3.74079711298952 bayes_pls_golite062009
endopeptidase activity 3.37014194828197 bayes_pls_golite062009
cysteine-type peptidase activity 3.05412701733177 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
ubiquitin thiolesterase activity 1.71956723967893 bayes_pls_golite062009
binding 1.3276268995308 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.16758945018031 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
thiolester hydrolase activity 0.86592833690416 bayes_pls_golite062009
ubiquitin-specific protease activity 0.495368836247989 bayes_pls_golite062009
nucleic acid binding 0.439226369799415 bayes_pls_golite062009
kininogen binding 0.41283715939055 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
protein binding 0.177568040298733 bayes_pls_golite062009
DNA binding 0.168761518285256 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle