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Protein Overview: USP16

General Information:
Name(s) found: USP16 [HGNC (HUGO)]
Description(s) found:
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  • gi|7717310|emb|CAB90432.1| human ubiquitin processing protease, EC 3.1.2.15 [Homo sapiens] [NCBI NR]
  • gi|75992941|ref|NP_001027582.1| ubiquitin specific protease 16 isoform a [Homo sapiens] [NCBI NR]
  • gi|6686071|sp|Q9Y5T5.1|UBP16_HUMAN RecName: Full=Ubiquitin carboxyl-terminal hydrolase 16; AltName: Full=Ubiquitin thioesterase 16; AltName: Full=Ubiquitin-specific-processing protease 16; AltName: Full=Deubiquitinating enzyme 16; AltName: Full=Ubiquitin- [NCBI NR]
  • gi|5454156|ref|NP_006438.1| ubiquitin specific protease 16 isoform a [Homo sapiens] [NCBI NR]
  • gi|4454565|gb|AAD20949.1| ubiquitin processing protease [Homo sapiens] [NCBI NR]
  • gi|119630334|gb|EAX09929.1| ubiquitin specific peptidase 16, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119630332|gb|EAX09927.1| ubiquitin specific peptidase 16, isoform CRA_a [Homo sapiens] [NCBI NR]
  • ubiquitin specific peptidase 16 [HGNC (HUGO)]
  • Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens GN=USP16 PE=1 SV=1 [Swiss-Prot]
  • (Q9Y5T5) Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.1.2.15) (Ubiquitin thiolesterase 16) (Ubiquitin-specific processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin processing protease UBP-M) [Swiss-Prot]
  • Ubiquitin carboxyl-terminal hydrolase 16 [hmr_yeast5_DM3-1_pombe.fasta]
  • ubiquitin specific protease 16; human ubiquitin processing protease [HMR_022704.fasta]
  • ubiquitin specific protease 16 isoform a; ubiquitin processing protease UBP-M; ubiquitin carboxyl-terminal hydrolase 16; ubiquitin thiolesterase 16; deubiquitinating enzyme 16 [071204_hmrz_cont.fasta]
  • ubiquitin specific protease 16 isoform a [Homo sapiens]gi|7717310|emb|CAB90432.1| human ubiquitin processing protease, EC 3.1.2.15 [Homo sapiens]gi|4454565|gb|AAD20949.1| ubiquitin processing protease [Homo sapiens]gi|6686071|sp|Q9Y5T5|UB16_HUMAN Ubiqu [nrdb_11152004_Chlamydomonas]
  • Ubiquitin carboxyl-terminal hydrolase 16 (Ubiquitin thiolesterase 16) (Ubiquitin-specific processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin processing protease UBP-M) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Ubiquitin carboxyl-terminal hydrolase 16 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_006447) ubiquitin specific protease 16; human ubiquitin processing protease [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • ubiquitin specific protease 16 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • ubiquitin specific protease 16 isoform a; ubiquitin processing protease UBP-M; ubiquitin carboxyl-terminal hydrolase 16; ubiquitin thiolesterase 16; deubiquitinating enzyme 16 [Homo sapiens] [HumanGallus06162005.fasta]
  • ubiquitin specific protease 16; human ubiquitin processing protease [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 16 (Ubiquitin thioesterase 16) (Ubiquitin-specific-processing protease 16) (Deubiquitinating enzyme 16) (Ubiquitin-processing protease UBP-M) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ubiquitin specific peptidase 16, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • human ubiquitin processing protease, EC 3.1.2.15 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ubiquitin processing protease [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=USP16 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 16 [human-ipi-250309-contam.fasta]
  • IPI:IPI00001780.1|SWISS-PROT:Q9Y5T5-1|ENSEMBL:ENSP00000334808;ENSP00000382858|REFSEQ:NP_001027582;NP_006438|H-INV:HIT000297755|VEGA:OTTHUMP00000096469;OTTHUMP00000096470 Tax_Id=9606 Gene_Symbol=USP16 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 16 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=USP16 Ubiquitin carboxyl-terminal hydrolase 16 ENSG00000156256 IPI00001780 IPI00428464 IPI00792644 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=USP16 Ubiquitin carboxyl-terminal hydrolase 16 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • Q9Y5T5;A8MU43;B3KN13;B4DFV8;B4DY37;Q53GP7;Q53HA0;Q5VKN8;Q8NEL3;Q9H3E6; RecName: Full=Ubiquitin carboxyl-terminal hydrolase 16; AltName: Full=Ubiquitin thioesterase 16; AltName: Full=Ubiquitin-specific-processing protease 16; AltName: Full=Deubiquitinating enzyme 16; AltName: Full=Ubiquitin-processing protease UBP-M; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 16 OS=Homo sapiens GN=USP16 [011711_HMR.fasta]
  • IPI:IPI00001780.1|SWISS-PROT:Q9Y5T5-1|TREMBL:D3DSD9|ENSEMBL:ENSP00000334808;ENSP00000382858|REFSEQ:NP_001027582;NP_006438|H-INV:HIT000297755|VEGA:OTTHUMP00000096469;OTTHUMP00000096470 Tax_Id=9606 Gene_Symbol=USP16 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 16 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=USP16 Synonyms=UBP-M ubiquitin carboxyl-terminal hydrolase 16 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 16 GN=USP16 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 823 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKRTKGKT VPIDDSSETL EPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK  60
   61 AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYVCD 120
  121 NEVQYCSSNQ LGQVVDYVRK QASITTPKPA EKDNGNIELE NKKLEKESKN EQEREKKENM 180
  181 AKENPPMNSP CQITVKGLSN LGNTCFFNAV MQNLSQTPVL RELLKEVKMS GTIVKIEPPD 240
  241 LALTEPLEIN LEPPGPLTLA MSQFLNEMQE TKKGVVTPKE LFSQVCKKAV RFKGYQQQDS 300
  301 QELLRYLLDG MRAEEHQRVS KGILKAFGNS TEKLDEELKN KVKDYEKKKS MPSFVDRIFG 360
  361 GELTSMIMCD QCRTVSLVHE SFLDLSLPVL DDQSGKKSVN DKNLKKTVED EDQDSEEEKD 420
  421 NDSYIKERSD IPSGTSKHLQ KKAKKQAKKQ AKNQRRQQKI QGKVLHLNDI CTIDHPEDSE 480
  481 YEAEMSLQGE VNIKSNHISQ EGVMHKEYCV NQKDLNGQAK MIESVTDNQK STEEVDMKNI 540
  541 NMDNDLEVLT SSPTRNLNGA YLTEGSNGEV DISNGFKNLN LNAALHPDEI NIEILNDSHT 600
  601 PGTKVYEVVN EDPETAFCTL ANREVFNTDE CSIQHCLYQF TRNEKLRDAN KLLCEVCTRR 660
  661 QCNGPKANIK GERKHVYTNA KKQMLISLAP PVLTLHLKRF QQAGFNLRKV NKHIKFPEIL 720
  721 DLAPFCTLKC KNVAEENTRV LYSLYGVVEH SGTMRSGHYT AYAKARTANS HLSNLVLHGD 780
  781 IPQDFEMESK GQWFHISDTH VQAVPTTKVL NSQAYLLFYE RIL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..161] PSI-BLAST 21.09691 No description for 2i50A was found.
    2 View Details [162..525] PSI-BLAST 52.69897 No description for 2gfoA was found.
    3 View Details [526..823] PSI-BLAST 34.39794 Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • cysteine-type peptidase activity
    		•  6.54685807643041 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  6.39247995905454 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  5.91394445088241 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  4.1832081096766 bayes_pls_golite062009
  • SUMO-specific protease activity
    		•  2.65263825059319 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  2.43852076378819 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.13534310479552 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.05460016317651 bayes_pls_golite062009
  • DNA binding
    		•  1.95013248594294 bayes_pls_golite062009
  • protein binding
    		•  1.92445772322782 bayes_pls_golite062009
  • binding
    		•  1.92046698500094 bayes_pls_golite062009
  • transcription activator activity
    		•  1.24058404587058 bayes_pls_golite062009
  • peptidase activity
    		•  1.2363147273892 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20242512567523 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.10408384086394 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • NEDD8-specific protease activity
    		•  0.687958315289315 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  0.519017048367076 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.473735812426592 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.415253171908598 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.144331158319621 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.117572636180329 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.117572636180329 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.100416047932277 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle