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View Structure Prediction Details

Protein: USP16
Organism: Homo sapiens
Length: 823 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for USP16.

Description E-value Query
Range
Subject
Range
gi|62896921 - gi|62896921|dbj|BAD96401.1| ubiquitin specific protease 16 isoform a variant [Homo sapiens]
0.0 [1..823] [1..823]
gi|114683768, gi... - gi|114683768|ref|XP_001160171.1| PREDICTED: ubiquitin specific protease 16 isoform 7 [Pan troglodyte...
0.0 [1..823] [1..826]
gi|109065603, gi... - gi|109065605|ref|XP_001102518.1| PREDICTED: similar to ubiquitin specific protease 16 isoform a isof...
0.0 [1..823] [1..826]
gi|74001074, gi|... - gi|74001076|ref|XP_535575.2| PREDICTED: similar to ubiquitin specific protease 16 isoform a isoform ...
0.0 [1..823] [1..826]

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Predicted Domain #1
Region A:
Residues: [1-161]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKRTKGKT VPIDDSSETL EPVCRHIRKG LEQGNLKKAL VNVEWNICQD CKTDNKVKDK  60
   61 AEEETEEKPS VWLCLKCGHQ GCGRNSQEQH ALKHYLTPRS EPHCLVLSLD NWSVWCYVCD 120
  121 NEVQYCSSNQ LGQVVDYVRK QASITTPKPA EKDNGNIELE N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.09691
Match: 2i50A
Description: No description for 2i50A was found.

Predicted Domain #2
Region A:
Residues: [162-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKLEKESKNE QEREKKENMA KENPPMNSPC QITVKGLSNL GNTCFFNAVM QNLSQTPVLR  60
   61 ELLKEVKMSG TIVKIEPPDL ALTEPLEINL EPPGPLTLAM SQFLNEMQET KKGVVTPKEL 120
  121 FSQVCKKAVR FKGYQQQDSQ ELLRYLLDGM RAEEHQRVSK GILKAFGNST EKLDEELKNK 180
  181 VKDYEKKKSM PSFVDRIFGG ELTSMIMCDQ CRTVSLVHES FLDLSLPVLD DQSGKKSVND 240
  241 KNLKKTVEDE DQDSEEEKDN DSYIKERSDI PSGTSKHLQK KAKKQAKKQA KNQRRQQKIQ 300
  301 GKVLHLNDIC TIDHPEDSEY EAEMSLQGEV NIKSNHISQE GVMHKEYCVN QKDLNGQAKM 360
  361 IESV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.69897
Match: 2gfoA
Description: No description for 2gfoA was found.

Predicted Domain #3
Region A:
Residues: [526-823]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDNQKSTEEV DMKNINMDND LEVLTSSPTR NLNGAYLTEG SNGEVDISNG FKNLNLNAAL  60
   61 HPDEINIEIL NDSHTPGTKV YEVVNEDPET AFCTLANREV FNTDECSIQH CLYQFTRNEK 120
  121 LRDANKLLCE VCTRRQCNGP KANIKGERKH VYTNAKKQML ISLAPPVLTL HLKRFQQAGF 180
  181 NLRKVNKHIK FPEILDLAPF CTLKCKNVAE ENTRVLYSLY GVVEHSGTMR SGHYTAYAKA 240
  241 RTANSHLSNL VLHGDIPQDF EMESKGQWFH ISDTHVQAVP TTKVLNSQAY LLFYERIL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.39794
Match: 1nb8A
Description: Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.91394445088241 bayes_pls_golite062009
ubiquitin thiolesterase activity 4.1832081096766 bayes_pls_golite062009
SUMO-specific protease activity 2.65263825059319 bayes_pls_golite062009
thiolester hydrolase activity 2.43852076378819 bayes_pls_golite062009
transcription regulator activity 2.13534310479552 bayes_pls_golite062009
nucleic acid binding 2.05460016317651 bayes_pls_golite062009
DNA binding 1.95013248594294 bayes_pls_golite062009
protein binding 1.92445772322782 bayes_pls_golite062009
binding 1.92046698500094 bayes_pls_golite062009
transcription activator activity 1.24058404587058 bayes_pls_golite062009
peptidase activity 1.2363147273892 bayes_pls_golite062009
transcription factor activity 1.20242512567523 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.10408384086394 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
cysteine-type endopeptidase activity 0.519017048367076 bayes_pls_golite062009
N-acetyltransferase activity 0.473735812426592 bayes_pls_golite062009
endopeptidase activity 0.415253171908598 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.144331158319621 bayes_pls_golite062009
lysine N-acetyltransferase activity 0.117572636180329 bayes_pls_golite062009
histone acetyltransferase activity 0.117572636180329 bayes_pls_golite062009
N-acyltransferase activity 0.100416047932277 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle