Protein Overview: COG2

General Information:
Name(s) found:	COG2 / YGR120C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|37362655\|ref\|NP_011635.2\| Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog2p [Sac [NCBI NR] gi\|110282946\|sp\|P53271.2\|COG2_YEAST RecName: Full=Conserved oligomeric Golgi complex subunit 2; Short=COG complex subunit 2; AltName: Full=Component of oligomeric Golgi complex 2; AltName: Full=Protein SEC35 [NCBI NR] Conserved oligomeric Golgi complex subunit 2 OS=Saccharomyces cerevisiae GN=COG2 PE=1 SV=2 [Swiss-Prot] COG2 Conserved oligomeric golgi complex [mips] Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [SGD] Chr VII from 730823-730035, reverse complement [yeastorf5.fasta] COG2 SGDID:S0003352, Chr VII from 730824-730036, reverse complement, Verified ORF [yeastflysequest.fasta] COG2 SGDID:S0003352, Chr VII from 730826-730038, reverse complement, Verified ORF [10112005cervSGD.fasta] Cog2p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] COG2 SGDID:S000003352, Chr VII from 730826-730038, reverse complement, Verified ORF, "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusio [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Protein SEC35) [nr-271106-contam.fasta] COG2 SGDID:S000003352, Chr VII from 730826-730038, reverse complement, Verified ORF, "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Conserved oligomeric Golgi complex subunit 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COG2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] COG2 SGDID:S000003352, Chr VII from 730821-730033, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" [yeast-030211-contam.fasta] COG2 SGDID:S000003352, Chr VII from 730821-730033, Genome Release 64-2-1, reverse complement, Verified ORF, "Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; the components of the Golgi complex are Gog1p through Cog8p" [20141208_orf_trans.fasta] YGR120C SGDID:S000003352, Chr VII from 730821-730033, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	262 amino acids
Gene Ontology:
Cellular Component:	Golgi transport complex [IPI] soluble fraction [IDA] peripheral to membrane of membrane fraction [IDA]
Biological Process:	ER to Golgi vesicle-mediated transport [IGI] intra-Golgi vesicle-mediated transport [IGI][IPI] retrograde transport, vesicle recycling within Golgi [IMP][TAS]
Molecular Function:	protein binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFLNDDELD LDLPVTAEIS KELFATEIEK YRESETNGTD VDNFDVDRFL VQKNFHYLPL  60
   61 DSLIRDLSGL SQKMVQTLLE QIRSNYDDYL TFSNTYTDEE NETLINLEKT QSDLQKFMTQ 120
  121 LDHLIKDDIS NTQEIIKDVL EYLKKLDEIY GSLRNHSQLT EALSLGKRLS KSLHEMCGIE 180
  181 PLEEEICSGL IEQLYKLITA SRRILESCAD SNSPYIHHLR NDYQDLLQEF QISLKILTEK 240
  241 CLENPSSLQN LSLTLVSIIK TA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		COG1 COG2 COG3 COG4 COG6 COG7 COG8
View Details	(MIPS) Mewes HW, et al. (2004)		COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8
View Details	Krogan NJ, et al. (2006)		COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8
View Details	Gavin AC, et al. (2006)		COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8 IML1
View Details	Qiu et al. (2008)		COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8 SEC22 SFB3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#19b Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)
View Run	MLP2	#19a Asynchronous Prep1-new search criteria	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PCF11	COG2	1	Unpublished Fields Lab Data
View Screen	SWC4	COG2	1	Hazbun TR, et al. (2003)
View Screen	RRB1	COG2	1	Unpublished Fields Lab Data
View Screen	CIN4	COG2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	COG2	Huh WK, et al. (2003)
View Data	COG2 and COP1	Huh WK, et al. (2003)
View Data	COG2 and ANP1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..262]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2