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Protein Overview: BET2

General Information:
Name(s) found: BET2 / YPR176C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 325 amino acids

    Gene Ontology:
    Cellular Component: Rab-protein geranylgeranyltransferase complex [IDALink to PubMed article]
    Biological Process: protein amino acid geranylgeranylation [IDALink to PubMed article]
    Molecular Function: Rab geranylgeranyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSLTLLKE KHIRYIESLD TKKHNFEYWL TEHLRLNGIY WGLTALCVLD SPETFVKEEV  60
   61 ISFVLSCWDD KYGAFAPFPR HDAHLLTTLS AVQILATYDA LDVLGKDRKV RLISFIRGNQ 120
  121 LEDGSFQGDR FGEVDTRFVY TALSALSILG ELTSEVVDPA VDFVLKCYNF DGGFGLCPNA 180
  181 ESHAAQAFTC LGALAIANKL DMLSDDQLEE IGWWLCERQL PEGGLNGRPS KLPDVCYSWW 240
  241 VLSSLAIIGR LDWINYEKLT EFILKCQDEK KGGISDRPEN EVDVFHTVFG VAGLSLMGYD 300
  301 NLVPIDPIYC MPKSVTSKFK KYPYK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) BET2 BET4 MRS6
    View Details Gavin AC, et al. (2002) BET2 BET4
    View Details Qiu et al. (2008) BET2 BET4 CDC43 RAM1 RAM2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data BET2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..15]
    [163..325]    		 PSI-BLAST 1053.68867 Rab geranylgeranyltransferase, beta subunit
    2 View Details [16..162] PSI-BLAST 1053.68867 Rab geranylgeranyltransferase, beta subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein prenyltransferase activity
    		•  13.7736019666673 bayes_pls_golite062009
  • protein geranylgeranyltransferase activity
    		•  12.9757276506747 bayes_pls_golite062009
  • Rab geranylgeranyltransferase activity
    		•  12.8088011327065 bayes_pls_golite062009
  • prenyltransferase activity
    		•  11.6786310564018 bayes_pls_golite062009
  • CAAX-protein geranylgeranyltransferase activity
    		•  10.5569796788906 bayes_pls_golite062009
  • protein farnesyltransferase activity
    		•  4.15546866363415 bayes_pls_golite062009
  • binding
    		•  1.68564752993879 bayes_pls_golite062009
  • protein binding
    		•  1.45455287827127 bayes_pls_golite062009
  • transferase activity
    		•  1.0950430724883 bayes_pls_golite062009
  • catalytic activity
    		•  0.497699107100544 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle