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Protein Overview: BET4

General Information:
Name(s) found: BET4 / YJL031C [SGD]
Description(s) found:
Found 20 descriptions.
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  • Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 327 amino acids

    Gene Ontology:
    Cellular Component: Rab-protein geranylgeranyltransferase complex [IDALink to PubMed article]
    Biological Process: protein amino acid geranylgeranylation [IDALink to PubMed article]
    Molecular Function: Rab geranylgeranyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHGIKRKQWT KELLRQKRVQ DEKKIYDYRS LTENVLNMRD EKIYSIEALK KTSELLEKNP  60
   61 EFNAIWNYRR DIIASLASEL EIPFWDKELV FVMMLLKDYP KVYWIWNHRL WVLKHYPTSS 120
  121 PKVWQTELAV VNKLLEQDAR NYHGWHYRRI VVGNIESITN KSLDKEEFEY TTIKINNNIS 180
  181 NYSAWHQRVQ IISRMFQKGE VGNQKEYIRT EISYIINAMF TDAEDQSVWF YIKWFIKNDI 240
  241 VCKTLDEQEY LKMLKDLREN ILLINNDEIE FSGKQNIWCL KILLVLEDIL EEKEALTERS 300
  301 SEQYLVQLID ADPLRKNRYL HLLEQHK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) BET2 BET4 MRS6
    View Details Gavin AC, et al. (2002) BET2 BET4
    View Details Qiu et al. (2008) BET2 BET4 CDC43 RAM1 RAM2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..242] PSI-BLAST 18.09691 Rab geranylgeranyltransferase alpha-subunit, N-terminal domain; Rab geranylgeranyltransferase alpha-subunit, insert domain; Rab geranylgeranyltransferase alpha-subunit, C-terminal domain
    2 View Details [243..327] PSI-BLAST 6.69897 FKBP51, C-terminal domain; FKBP51, N-terminal domains

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein prenyltransferase activity
    		•  14.5503734940473 bayes_pls_golite062009
  • Rab geranylgeranyltransferase activity
    		•  13.1624958019148 bayes_pls_golite062009
  • protein geranylgeranyltransferase activity
    		•  13.1460127219249 bayes_pls_golite062009
  • prenyltransferase activity
    		•  12.4552179391942 bayes_pls_golite062009
  • protein farnesyltransferase activity
    		•  5.75066035906508 bayes_pls_golite062009
  • CAAX-protein geranylgeranyltransferase activity
    		•  3.82151622786875 bayes_pls_golite062009
  • transferase activity
    		•  1.86754243570948 bayes_pls_golite062009
  • binding
    		•  1.29714843812125 bayes_pls_golite062009
  • catalytic activity
    		•  0.874200184943744 bayes_pls_golite062009
  • protein binding
    		•  0.439760416772506 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle