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Protein Overview: CDC43

General Information:
Name(s) found: CDC43 / YGL155W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: CAAX-protein geranylgeranyltransferase complex [IDALink to PubMed article]
    intracellular [TASLink to PubMed article]
    Biological Process: small GTPase mediated signal transduction [TASLink to PubMed article]
    cellular calcium ion homeostasis [IMPLink to PubMed article]
    protein amino acid geranylgeranylation [IDALink to PubMed article]
    Molecular Function: protein geranylgeranyltransferase activity [IDALink to PubMed articleLink to PubMed article]
    CAAX-protein geranylgeranyltransferase activity [IDALink to PubMed article]
    signal transducer activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCQATNGPSR VVTKKHRKFF ERHLQLLPSS HQGHDVNRMA IIFYSISGLS IFDVNVSAKY  60
   61 GDHLGWMRKH YIKTVLDDTE NTVISGFVGS LVMNIPHATT INLPNTLFAL LSMIMLRDYE 120
  121 YFETILDKRS LARFVSKCQR PDRGSFVSCL DYKTNCGSSV DSDDLRFCYI AVAILYICGC 180
  181 RSKEDFDEYI DTEKLLGYIM SQQCYNGAFG AHNEPHSGYT SCALSTLALL SSLEKLSDKF 240
  241 KEDTITWLLH RQVSSHGCMK FESELNASYD QSDDGGFQGR ENKFADTCYA FWCLNSLHLL 300
  301 TKDWKMLCQT ELVTNYLLDR TQKTLTGGFS KNDEEDADLY HSCLGSAALA LIEGKFNGEL 360
  361 CIPQEIFNDF SKRCCF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC43 RAM2
    View Details (MIPS) Mewes HW, et al. (2004) CDC43 RAM2
    View Details Krogan NJ, et al. (2006) CDC43 RAM2
    View Details Qiu et al. (2008) BET2 BET4 CDC43 RAM1 RAM2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CDC43 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..19]
    [198..376]    		 PSI-BLAST 232.54902 Rab geranylgeranyltransferase, beta subunit
    2 View Details [20..197] PSI-BLAST 232.54902 Rab geranylgeranyltransferase, beta subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein prenyltransferase activity
    		•  13.7736019666673 bayes_pls_golite062009
  • protein geranylgeranyltransferase activity
    		•  12.9757276506747 bayes_pls_golite062009
  • Rab geranylgeranyltransferase activity
    		•  12.8088011327065 bayes_pls_golite062009
  • prenyltransferase activity
    		•  11.6786310564018 bayes_pls_golite062009
  • CAAX-protein geranylgeranyltransferase activity
    		•  10.5569796788906 bayes_pls_golite062009
  • protein farnesyltransferase activity
    		•  4.15546866363415 bayes_pls_golite062009
  • binding
    		•  1.68564752993879 bayes_pls_golite062009
  • transferase activity
    		•  1.0950430724883 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.854896924803117 bayes_pls_golite062009
  • catalytic activity
    		•  0.497699107100544 bayes_pls_golite062009
  • protein binding
    		•  0.404098609552806 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle