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View Structure Prediction Details

Protein: CDC43
Organism: Saccharomyces cerevisiae
Length: 376 amino acids
Reference: Malmstr÷m L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CDC43.

Description E-value Query
Range
Subject
Range
PGTB1_YEAST - Geranylgeranyl transferase type-1 subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
CDC43 - Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine resi...
0.0 [1..376] [1..376]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [5..369] [12..322]
PGTB_MOUSE, PGTB... - Geranylgeranyl transferase type-2 subunit beta - Mus musculus (Mouse), Geranylgeranyl transferase ty...
4.0E-96 [5..369] [20..330]
PGGT1B - protein geranylgeranyltransferase type I, beta subunit
1.0E-91 [10..356] [19..336]
PGTB1_RAT - Geranylgeranyl transferase type-1 subunit beta OS=Rattus norvegicus GN=Pggt1b PE=1 SV=1
4.0E-91 [10..356] [19..336]
gi|11878247 - gi|11878247|gb|AAG40865.1|AF311225_1 geranylgeranyltransferase beta subunit [Arabidopsis thaliana]
3.0E-89 [7..361] [30..363]
betaggt-II-PA - The gene ├?Ž├?┬▓ subunit of type II geranylgeranyl transferase is referred to in FlyBase by the...
gi|220956328, gi... - gi|220956328|gb|ACL90707.1| betaggt-II-PA [synthetic construct], gi|220946648|gb|ACL85867.1| betaggt...
6.0E-89 [15..369] [33..336]

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Predicted Domain #1
Region A:
Residues: [1-19]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCQATNGPSR VVTKKHRKF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [198-376]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YIMSQQCYNG AFGAHNEPHS GYTSCALSTL ALLSSLEKLS DKFKEDTITW LLHRQVSSHG  60
   61 CMKFESELNA SYDQSDDGGF QGRENKFADT CYAFWCLNSL HLLTKDWKML CQTELVTNYL 120
  121 LDRTQKTLTG GFSKNDEEDA DLYHSCLGSA ALALIEGKFN GELCIPQEIF NDFSKRCCF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 232.54902
Match: 1dceB_
Description: Rab geranylgeranyltransferase, beta subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein prenyltransferase activity 13.7736019666673 bayes_pls_golite062009
protein geranylgeranyltransferase activity 12.9757276506747 bayes_pls_golite062009
Rab geranylgeranyltransferase activity 12.8088011327065 bayes_pls_golite062009
prenyltransferase activity 11.6786310564018 bayes_pls_golite062009
CAAX-protein geranylgeranyltransferase activity 10.5569796788906 bayes_pls_golite062009
protein farnesyltransferase activity 4.15546866363415 bayes_pls_golite062009
binding 1.68564752993879 bayes_pls_golite062009
transferase activity 1.0950430724883 bayes_pls_golite062009
enzyme regulator activity 0.854896924803117 bayes_pls_golite062009
catalytic activity 0.497699107100544 bayes_pls_golite062009
protein binding 0.404098609552806 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [20-197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FERHLQLLPS SHQGHDVNRM AIIFYSISGL SIFDVNVSAK YGDHLGWMRK HYIKTVLDDT  60
   61 ENTVISGFVG SLVMNIPHAT TINLPNTLFA LLSMIMLRDY EYFETILDKR SLARFVSKCQ 120
  121 RPDRGSFVSC LDYKTNCGSS VDSDDLRFCY IAVAILYICG CRSKEDFDEY IDTEKLLG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 232.54902
Match: 1dceB_
Description: Rab geranylgeranyltransferase, beta subunit
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle