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Protein Overview: PGTB1_RAT

General Information:
Name(s) found: PGTB1_RAT [Swiss-Prot]
Description(s) found:
Found 140 descriptions.
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  • Geranylgeranyl transferase type-1 subunit beta OS=Rattus norvegicus GN=Pggt1b PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 377 amino acids

    Gene Ontology:
    Cellular Component: CAAX-protein geranylgeranyltransferase complex [IDA][TAS]
    Biological Process: response to cytokine stimulus [IMP]
    negative regulation of nitric-oxide synthase 2 biosynthetic process [IMP]
    positive regulation of cell proliferation [IMP]
    positive regulation of cell cycle [IMP]
    response to protein stimulus [IDA]
    protein amino acid geranylgeranylation [TAS]
    Molecular Function: zinc ion binding [IDA]
    protein binding [IPI]
    drug binding [IDA]
    prenyltransferase activity [IEA]
    metal ion binding [IEA]
    peptide binding [IDA]
    isoprenoid binding [IDA]
    transferase activity [IEA]
    CAAX-protein geranylgeranyltransferase activity [IDA][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAATEDDRLA GSGEGERLDF LRDRHVRFFQ RCLQVLPERY SSLETSRLTI AFFALSGLDM  60
   61 LDSLDVVNKD DIIEWIYSLQ VLPTEDRSNL DRCGFRGSSY LGIPFNPSKN PGTAHPYDSG 120
  121 HIAMTYTGLS CLIILGDDLS RVDKEACLAG LRALQLEDGS FCAVPEGSEN DMRFVYCASC 180
  181 ICYMLNNWSG MDMKKAISYI RRSMSYDNGL AQGAGLESHG GSTFCGIASL CLMGKLEEVF 240
  241 SEKELNRIKR WCIMRQQNGY HGRPNKPVDT CYSFWVGATL KLLKIFQYTN FEKNRNYILS 300
  301 TQDRLVGGFA KWPDSHPDAL HAYFGICGLS LMEESGICKV HPALNVSTRT SERLRDLHQS 360
  361 WKTKDSKQCS DNVHISS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..377] PSI-BLAST 107.0 Protein Geranylgeranyltransferase type-I Complexed with Geranylgeranyl Diphosphate

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein prenyltransferase activity
    		•  13.7736019666673 bayes_pls_golite062009
  • protein geranylgeranyltransferase activity
    		•  12.9757276506747 bayes_pls_golite062009
  • Rab geranylgeranyltransferase activity
    		•  12.8088011327065 bayes_pls_golite062009
  • prenyltransferase activity
    		•  11.6786310564018 bayes_pls_golite062009
  • CAAX-protein geranylgeranyltransferase activity
    		•  10.5569796788906 bayes_pls_golite062009
  • protein farnesyltransferase activity
    		•  4.15546866363415 bayes_pls_golite062009
  • binding
    		•  1.68564752993879 bayes_pls_golite062009
  • protein binding
    		•  1.45455287827127 bayes_pls_golite062009
  • transferase activity
    		•  1.0950430724883 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.854896924803117 bayes_pls_golite062009
  • catalytic activity
    		•  0.497699107100544 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle