Protein Overview: BET2

General Information:
Name(s) found:	BET2 / YPR176C [SGD]
Description(s) found: Found 27 descriptions. SHOW ALL	Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	325 amino acids
Gene Ontology:
Cellular Component:	Rab-protein geranylgeranyltransferase complex [IDA]
Biological Process:	protein amino acid geranylgeranylation [IDA]
Molecular Function:	Rab geranylgeranyltransferase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSLTLLKE KHIRYIESLD TKKHNFEYWL TEHLRLNGIY WGLTALCVLD SPETFVKEEV  60
   61 ISFVLSCWDD KYGAFAPFPR HDAHLLTTLS AVQILATYDA LDVLGKDRKV RLISFIRGNQ 120
  121 LEDGSFQGDR FGEVDTRFVY TALSALSILG ELTSEVVDPA VDFVLKCYNF DGGFGLCPNA 180
  181 ESHAAQAFTC LGALAIANKL DMLSDDQLEE IGWWLCERQL PEGGLNGRPS KLPDVCYSWW 240
  241 VLSSLAIIGR LDWINYEKLT EFILKCQDEK KGGISDRPEN EVDVFHTVFG VAGLSLMGYD 300
  301 NLVPIDPIYC MPKSVTSKFK KYPYK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		BET2 BET4 MRS6
View Details	Gavin AC, et al. (2002)		BET2 BET4
View Details	Qiu et al. (2008)		BET2 BET4 CDC43 RAM1 RAM2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SEC17	BET2	1	Unpublished Fields Lab Data
View Screen	HMT1	BET2	1	Unpublished Fields Lab Data
View Screen	SWI5	BET2	1	Unpublished Fields Lab Data
View Screen	RAD6	BET2	1	Unpublished Fields Lab Data
View Screen	SPO21	BET2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	BET2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..15] [163..325]	PSI-BLAST	1053.68867	Rab geranylgeranyltransferase, beta subunit
2	View Details	[16..162]	PSI-BLAST	1053.68867	Rab geranylgeranyltransferase, beta subunit

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
protein prenyltransferase activity	13.7736019666673	bayes_pls_golite062009
protein geranylgeranyltransferase activity	12.9757276506747	bayes_pls_golite062009
Rab geranylgeranyltransferase activity	12.8088011327065	bayes_pls_golite062009
prenyltransferase activity	11.6786310564018	bayes_pls_golite062009
CAAX-protein geranylgeranyltransferase activity	10.5569796788906	bayes_pls_golite062009
protein farnesyltransferase activity	4.15546866363415	bayes_pls_golite062009
binding	1.68564752993879	bayes_pls_golite062009
protein binding	1.45455287827127	bayes_pls_golite062009
transferase activity	1.0950430724883	bayes_pls_golite062009
catalytic activity	0.497699107100544	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.89

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2