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Protein Overview: ASN1

General Information:
Name(s) found: ASN1 / YPR145W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 572 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: asparagine biosynthetic process [TASLink to PubMed article]
    Molecular Function: asparagine synthase (glutamine-hydrolyzing) activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCGIFAAFRH EDVHRYKPKA LQLSKRIRHR GPDWSGNAIK NSTIFVHERL AIVGVESGAQ  60
   61 PITSSDGEYM LCVNGEIYNH IQLREECADY EFGTLSDCEP IIPMYLKHDI DAPKYLDGMF 120
  121 AWTLYDAKQD RIVAARDPIG ITTLYMGRSS ASPKTVYFAS ELKCLTDDCD TITAFPPGHV 180
  181 YDSKTDKITR YFTPDWLDEK RIPSTPIDYM AIRHSLEKAV RKRLMAEVPY GVLLSGGLDS 240
  241 SLIASIAARE TAKATNDVEP STYDSKARHL AGIDDDGKLH TAGWTSLHSF AIGLPNAPDL 300
  301 QAARKVAKFI GSIHHEHTFT LQEGLDALDD VIYHLETYDV TTIRASTPMF LLSRKIKAQG 360
  361 VKMVLSGEGS DEIFGGYLYF AQAPSAAEFH TESVQRVKNL HLADCLRANK STMAWGLEAR 420
  421 VPFLDREFLQ LCMNIDPNEK MIKPKEGRIE KYILRKAFDT TGEPDAKPYL PEEILWRQKE 480
  481 QFSDGVGYSW IDGLKDTAEA VISDEMFASP KAEWGSDIPT TKEAFWYRLK FDALFPQKTV 540
  541 ADTVMRWIPK ADWGCAEDPS GRYAQIHEKH IE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ASN1 ASN2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ASN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..192] PSI-BLAST 1614.0 Asparagine synthetase B, C-terminal domain; Asparagine synthetase B, N-terminal domain
    2 View Details [193..572] PSI-BLAST 1614.0 Asparagine synthetase B, C-terminal domain; Asparagine synthetase B, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • asparagine synthase (glutamine-hydrolyzing) activity
    		•  3.86770527955716 bayes_pls_golite062009
  • asparaginase activity
    		•  2.94567124791739 bayes_pls_golite062009
  • peptidase activity
    		•  1.76298553502805 bayes_pls_golite062009
  • DNA binding
    		•  1.66643360311025 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.65897778831304 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.58381740825719 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.56290563467621 bayes_pls_golite062009
  • acid-ammonia (or amide) ligase activity
    		•  1.41109692769794 bayes_pls_golite062009
  • N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
    		•  1.2528157874993 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009
  • binding
    		•  1.18139971903068 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  1.17174228126736 bayes_pls_golite062009
  • hydrolase activity
    		•  1.05106912722792 bayes_pls_golite062009
  • protein binding
    		•  1.03373728327879 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle