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Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the reaction: glucosaminyl-inositol (GlcN-Ins) + L-cysteine + ATP = desacetylmycothiol (Cys-GlcN-Ins) + AMP + diphosphate + 2 H+. Catalysis of the reaction: ATP + L-glutamate + putrescine = ADP + phosphate + gamma-L-glutamylputrescine. Catalysis of the reactions: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate and (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide. Catalysis of the reaction: NH3 + L-aspartate + ATP = phosphate + L-asparagine + ADP. Catalysis of the reaction: reduced glutathione + glutathionylspermidine + ATP = trypanothione + ADP + phosphate. Catalysis of the reaction: ATP + D-aspartate + [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n = [beta-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate. Catalysis of the reaction: ATP + 4-methylene-L-glutamate + NH3 = AMP + diphosphate + 4-methylene-L-glutamine. Catalysis of the reaction: ATP + L-glutamate + ethylamine = ADP + phosphate + N5-ethyl-L-glutamine. Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate. Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: acid-ammonia (or amide) ligase activity
Acc: GO:0016880
Aspect: Molecular Function
Desc: Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate.
Synonyms:
  • amide synthase activity
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 57 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016880 - acid-ammonia (or amide) ligase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle