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Protein Overview: PUS1

General Information:
Name(s) found: PUS1 / YPL212C [SGD]
Description(s) found:
Found 25 descriptions.
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  • tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 544 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    tRNA modification [IDALink to PubMed article]
    Molecular Function: RNA binding [IEA]
    pseudouridine synthase activity [IDA][IEA]
    isomerase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEENLRPAY DDQVNEDVYK RGAQSKLTKA RKADFDDEKD KKKDNDKHID KRPKSGPRLD  60
   61 ENGNPLPKEP RLPKRKVAVM VGYCGTGYHG MQYNPPNPTI ESALFKAFVE AGAISKDNSN 120
  121 DLKKNGFMRA ARTDKGVHAG GNLISLKMII EDPDIKQKIN EKLPEGIRVW DIERVNKAFD 180
  181 CRKMCSSRWY EYLLPTYSLI GPKPGSILYR DIEESKTELP GVLDEDLESK EFWEEFKKDA 240
  241 NEKFSTEEIE AILAYVPPAR DEFDINEELY QKVKKYKQLE NAHRRRYRIS AAKLAKFRAS 300
  301 TSQYLGAHNF HNFTLGKDFK EPSAIRFMKD IKVSDPFVIG DAQTEWISIK IHGQSFMLHQ 360
  361 IRKMVSMATL ITRCGCPVER ISQAYGQQKI NIPKAPALGL LLEAPVFEGY NKRLEQFGYK 420
  421 AIDFSKYQDE VDKFKMKHIY DKIYKEEVDE NVFNAFFSYI DSFNKVTGAQ GEETADKSGP 480
  481 AVQKSIFEFL TAKGIPGLTD APESNKKIKQ RKRMEEEEAA SKKAEISSTT QSNEPEVQPE 540
  541 AAAN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) APL5 APL6 APM3 APS3 PUS1
    View Details Gavin AC, et al. (2002) PUS1 UTP22

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PUS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..64] deduced N/A No confident structure predictions are available.
    2 View Details [65..201] PSI-BLAST 100.68867 Pseudouridine synthase I
    3 View Details [202..306] PSI-BLAST 100.68867 Pseudouridine synthase I
    4 View Details [307..544] MSA 3.146957 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle