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Protein Overview: APS3

General Information:
Name(s) found: APS3 / YJL024C [SGD]
Description(s) found:
Found 34 descriptions.
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  • Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 194 amino acids

    Gene Ontology:
    Cellular Component: AP-3 adaptor complex [ISSLink to PubMed article]
    Biological Process: vesicle-mediated transport [TASLink to PubMed article]
    Golgi to vacuole transport [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIHAVLIFNK KCQPRLVKFY TPVDLPKQKL LLEQVYELIS QRNSDFQSSF LVTPPSLLLS  60
   61 NENNNDEVNN EDIQIIYKNY ATLYFTFIVD DQESELAILD LIQTFVESLD RCFTEVNELD 120
  121 LIFNWQTLES VLEEIVQGGM VIETNVNRIV ASVDELNKAA ESTDSKIGRL TSTGFGSALQ 180
  181 AFAQGGFAQW ATGQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) APL5 APL6 APM3 APS3
    View Details (MIPS) Mewes HW, et al. (2004) APL5 APL6 APM3 APS3
    View Details Krogan NJ, et al. (2006) APL5 APL6 APM3 APS3 PUS1
    View Details Gavin AC, et al. (2002) APL1 APL3 APL5 APL6 APM3 APM4 APS2 APS3 CKB1 ENO2
    View Details Qiu et al. (2008) APL5 APL6 APM3 APS3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data APS3 Huh WK, et al. (2003)
    View Data APS3 and COP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] PSI-BLAST 175.30103 Sigma2 adaptin (clathrin coat assembly protein AP17)
    2 View Details [104..194] PSI-BLAST 175.30103 Sigma2 adaptin (clathrin coat assembly protein AP17)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle