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Protein Overview: APS2

General Information:
Name(s) found: APS2 / YJR058C [SGD]
Description(s) found:
Found 36 descriptions.
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  • Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 147 amino acids

    Gene Ontology:
    Cellular Component: AP-2 adaptor complex [ISSLink to PubMed article]
    Biological Process: vesicle-mediated transport [ISSLink to PubMed article][TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVQFILCFN KQGVVRLVRW FDVHSSDPQR SQDAIAQIYR LISSRDHKHQ SNFVEFSDST  60
   61 KLIYRRYAGL YFVMGVDLLD DEPIYLCHIH LFVEVLDAFF GNVCELDIVF NFYKVYMIMD 120
  121 EMFIGGEIQE ISKDMLLERL SILDRLD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) APL1 APM4 APS2
    View Details (MIPS) Mewes HW, et al. (2004) APL1 APL3 APM4 APS2
    View Details Krogan NJ, et al. (2006) APM4 APS2
    View Details Gavin AC, et al. (2002) APL1 APL3 APL5 APL6 APM3 APM4 APS2 APS3 CKB1 ENO2
    View Details Qiu et al. (2008) APL1 APL3 APS2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data APS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..90] PSI-BLAST 309.0 Sigma2 adaptin (clathrin coat assembly protein AP17)
    2 View Details [91..147] PSI-BLAST 309.0 Sigma2 adaptin (clathrin coat assembly protein AP17)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle