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Protein Overview: APM4

General Information:
Name(s) found: APM4 / YOL062C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 491 amino acids

    Gene Ontology:
    Cellular Component: AP-2 adaptor complex [ISSLink to PubMed articleLink to PubMed article]
    Biological Process: vesicle-mediated transport [TASLink to PubMed article]
    intracellular protein transport [ISSLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MISGVLVYSS RGELVLNKFF KNSLKRSISD IFRVQVINNL DVRSPVLTLG STTFHHIRSR  60
   61 HGDNLWLVTI TRSNANSAAI WEFLYKLDAV MNAYRLDREE ALKEEFMIVH EMLDIMLGGN 120
  121 GIPIDTELNS VIAQMSVKPV RNMGGLLDSP DGNDVLSSSS SPTSSAGELH FPKFLTKRSS 180
  181 SFLGQGDSTS DFYDNNKITW RPKGIIHKKD EVFLYVNERI NILVSRDGSI LKSYVDGTID 240
  241 ITTHLSGTPI CRFGLNDSLG MQSEDEKKWL AQQQRHSGSD FGNKNFIPKA AAGSVLLEDC 300
  301 KFHECVSLDK FNRNHIIEFV PPDGSMELMK YHVRDNINLP FKVTPIVTHS TRDNEIDYRI 360
  361 TLKSLFPGKL SAKDVVLHIP VPPSTVDCKI SVSNGHCKFV PEENAMIWRF NKYNGLTENT 420
  421 LSAVTVSTSD TTQLNLQQWT RPPISLEFEV MMFSNSGLVV RYFTISGKDS KHRAVKWIKY 480
  481 ISKAGSYEVR Y

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) APL1 APM4 APS2
    View Details (MIPS) Mewes HW, et al. (2004) APL1 APL3 APM4 APS2
    View Details Krogan NJ, et al. (2006) APM4 APS2
    View Details Gavin AC, et al. (2006) APL1 APM4
    View Details Gavin AC, et al. (2002) APL1 APL3 APL5 APL6 APM3 APM4 APS2 APS3 CKB1 ENO2
    View Details Ho Y, et al. (2002) APM4 SEC53
    View Details Qiu et al. (2008) APL1 APL3 APM4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data APM4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..179] PSI-BLAST 842.9794 Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; Mu2 adaptin (clathrin coat assembly protein AP50)
    2 View Details [180..491] PSI-BLAST 842.9794 Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor; Mu2 adaptin (clathrin coat assembly protein AP50)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle