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Protein Overview: APL1

General Information:
Name(s) found: APL1 / YJR005W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 700 amino acids

    Gene Ontology:
    Cellular Component: AP-2 adaptor complex [ISSLink to PubMed article]
    Biological Process: vesicle-mediated transport [ISSLink to PubMed article][TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDQKVFARY KANEIVTDLQ HFGVKKFKSN ITRRKNALRK IIANLVLGNY GEMSVLFSEL  60
   61 LKFWQIEDDL EVKRICHEYI RVIGALKPQQ AREALPFIMD DFKSRDEKLQ IMALRTLVLV 120
  121 PVKELSDQAF DCIISLVNHK SPPEQVTRTA IYALLDLDEI DHERVLGLSS ILHDIVKAQS 180
  181 SSPEVIVAAL HTLYSIHEKN ANMEPFRIPL ELAFDMLELL PELNEWNKAT VLEVLTTSVV 240
  241 PQHYLDTHEM IELALPYLQQ VNTYVVLNSL KFIMYLLNYV DVIKETLAEK LSNSVIALLD 300
  301 KPPELQFLVL RNVILLLLSR ESSLLRLDIS YFFIEYNDPI YIKDTKLECL YLLANKETLP 360
  361 RILEELEQYA TDIDIQMSRK SVRAIGNLAV KLDEDSVHDC VAVLLDLLEF GVDYVVQEII 420
  421 SVFRNILRKY PNNFKANVTE LVKHTEVVQE PESKNAMIWI ITQYSDVIPN YLELFRVFSS 480
  481 NMFSETLEVQ FSILNSAIKF FIRSPTKETE ELCMDLLKGC IDHENNPDLR DKTLMYWRLL 540
  541 SLTKTSRISN AITFESLKSV LDGELPLIEM NTKLDPTVLE ELELNIGTIV SIYLKPVSHI 600
  601 FRLNKTKLLP QSPILNPNKD LLPVVGNSFP PTGANRDRQN SESQSSTKSR KTAMMDDYDK 660
  661 PAEKINQLKG KRKSSSNNPS KLSRKPSTLL RKLSMKRPFS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) APL1 APL3 APM4 APS2
    View Details (MIPS) Mewes HW, et al. (2004) APL1 APL3 APM4 APS2
    View Details Krogan NJ, et al. (2006) ALY2 APL1 APL3 IST1
    View Details Gavin AC, et al. (2006) APL1 APM4
    View Details Gavin AC, et al. (2002) APL1 APL3 APL5 APL6 APM3 APM4 APS2 APS3 CKB1 ENO2
    View Details Qiu et al. (2008) APL1 APL3 APM4 APS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data APL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..97] PSI-BLAST 745.0103 Adaptin beta subunit N-terminal fragment
    2 View Details [98..205] PSI-BLAST 745.0103 Adaptin beta subunit N-terminal fragment
    3 View Details [206..341]
    [570..611]    		 PSI-BLAST 745.0103 Adaptin beta subunit N-terminal fragment
    4 View Details [342..434] PSI-BLAST 745.0103 Adaptin beta subunit N-terminal fragment
    5 View Details [435..569] PSI-BLAST 745.0103 Adaptin beta subunit N-terminal fragment
    6 View Details [612..700] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle