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Protein Overview: RTT10

General Information:
Name(s) found: RTT10 / YPL183C [SGD]
Description(s) found:
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  • gi|74676484|sp|Q08924.1|YP183_YEAST RecName: Full=Uncharacterized WD repeat-containing protein YPL183C [NCBI NR]
  • gi|6325074|ref|NP_015142.1| Cytoplasmic protein of unknown function, plays a role in restricting Ty1 transposition; Rtt10p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S65195 probable membrane protein YPL183c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1370384|emb|CAA97892.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Uncharacterized WD repeat-containing protein YPL183C OS=Saccharomyces cerevisiae GN=YPL183C PE=1 SV=1 [Swiss-Prot]
  • Protein of unknown function localised to cytoplasm [mips]
  • Cytoplasmic protein with a role in regulation of Ty1 transposition [SGD]
  • >Q08924 (Q08924) Chromosome XVI reading frame ORF YPL183C [4932.FASTACCERV.txt]
  • Chr XVI from 202535-199494, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XVI from 199494-202535, reverse complement [yeastorf3.fasta]
  • YPL183C, Chr XVI from 199494-202535, reverse complement [yeast_orfs2]
  • YPL183C SGDID:S0006104, Chr XVI from 202535-199494, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • Ypl183cp [Saccharomyces cerevisiae]gi|1370384|emb|CAA97892.1| unnamed protein product [Saccharomyces cerevisiae]gi|2132992|pir||S65195 probable membrane protein YPL183c - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • (Q08924) ORF YPL183c [cerv4932.FASTAC]
  • YPL183C SGDID:S000006104, Chr XVI from 202535-199494, reverse complement, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • RTT10 SGDID:S000006104, Chr XVI from 202535-199494, reverse complement, Verified ORF, "Cytoplasmic protein with a role in regulation of Ty1 transposition" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • hypothetical protein; Ypl183cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • WD repeat protein YPL183C [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • RTT10 SGDID:S000006104, Chr XVI from 202536-199495, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic protein with a role in regulation of Ty1 transposition" [yeast-030211-contam.fasta]
  • RTT10 SGDID:S000006104, Chr XVI from 202536-199495, Genome Release 64-2-1, reverse complement, Verified ORF, "WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6" [20141208_orf_trans.fasta]
  • YPL183C SGDID:S000006104, Chr XVI from 202536-199495, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoplasmic protein with a role in regulation of Ty1 transposition" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1013 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKDLSHYGPA LCVKFYNDYV LAGYGPFIHV YDYHSATLIN KCRLFHYNKV HGLSLSSEGK  60
   61 ILAYGARSVT IVELEDVLKK ESLVDFERIN SDWITGATFS FDNLQIYLLT CYNKVLICDL 120
  121 NCEVLFRKSL GGERSILYSG IIKVFGPDKV YVNAGTVMGG VIIWDLFSET KIHNLLGHEG 180
  181 SIFYVNLSNN GRYVASCSDD RSIRLWDLET GKQLSVGWSH TARIWNLMFF DNDSKLISVS 240
  241 EDCTCRVWNI IESRENVAEL SISNVYEVHL IKSIWGVDVK DDEMIAVTSG NDGRLKLIDL 300
  301 LQLKRHGDEE TSFSLDDIAK QCGDIFEKNE SIKGFQWFSF GVIAITSLGK ILKYSDVTKQ 360
  361 WKLLLTNEKF NSYPITNGIQ TQNIAVFSNN KSDILLIKFS KDSADIIETE EFHLDELSKT 420
  421 NNCLVTEYDD DSFLLTLQSP NPREKFVCLE ISLQNLKIKS KHCFNKPENF SSSCLTSFRN 480
  481 HILVGSRFST LVIYNLLDES EEPFIIRRLS PGDTTTSIEF VEDKDNSAVF SVTNRDGYYV 540
  541 FIELTKNSLE EGPYRLSYKV LHSNKMMKGF LEGAFFNSKG EYITYGFKSS LFYLYNETNC 600
  601 YELASEVCGG SHRLWNLAKI TDGHVLMYIK ASRFHLRKIY NSIVPETLEN GVHGREIRDI 660
  661 SICPVSNTNT NDNFKDGHIF CTASEDTTIK LGYFNNRTGK VQNFWTQRKH VSGLQRCQFI 720
  721 NHKLMISSSA REELFLWELN DKYNKRPYMT IRQALPVSTN NSDLRIMDFD VKFISQSGDF 780
  781 LLVTVYSDST IKIWHYRENQ NKFDLIMQGR YKTCCLFNVV FIALKEELLV VISPTDGHLV 840
  841 VYNITEYVPF SVDPISGDLV DHKLDATISN LPAPVAQLPV HQSGVKSLDY VANATRTSAT 900
  901 ILTGGDDNGL GLSNLKLDDS NKVTLKTSDF IAAAASSTIT SGMLINGGKE VITTSVDQVI 960
  961 RAWEITAGKL SLVDKKRTTV ADTGSLEIIS NDEDADSEKT LLIGGVGLSI WKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CLB1 CUE5 LSB3 RTT10 TRM7 YMR259C YSC84

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RTT10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..116] PSI-BLAST 124.10721 beta1-subunit of the signal-transducing G protein heterotrimer
    2 View Details [117..419] PSI-BLAST 126.9794 Tup1, C-terminal domain
    3 View Details [420..498] PSI-BLAST 6.221849 Surface layer protein
    4 View Details [499..811] MSA 16.952993 View MSA. No confident structure predictions are available.
    5 View Details [812..1013] MSA 2.148995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.826090766828089 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.579815310385678 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.570141050045461 bayes_pls_golite062009
  • transcription factor binding
    		•  0.271710180601245 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.259860754265901 bayes_pls_golite062009
  • DNA binding
    		•  0.0736878329528894 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle