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Protein Overview: PPQ1

General Information:
Name(s) found: PPQ1 / YPL179W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 549 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: regulation of translation [IMPLink to PubMed article]
    protein amino acid dephosphorylation [ISSLink to PubMed article]
    Molecular Function: protein serine/threonine phosphatase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRSPSRSNN NFAVPNCSTN SNSSQQQLTT PSDDLNSNEP NDPDDSRSLP TIKKFNNKHS  60
   61 INNYNTLASA GKNNNNKRAS NDNLLIPGEN AHKQKIYTKD ENLKSLYLDI DVSVAKALSS 120
  121 SATAPKLINT ARTSSTTTAT TSNNILTSPS YRESNYSSPS SYSFSSYYSS ATSASSSTSS 180
  181 FLKSSGLSSR VKSPSSSVKA GSFGAPSSPT SGIPNPKSSK KPIFLRRYSH DTSSNEGLDI 240
  241 DVAIEKLLQV GESREITKTS KKKNFPFHSW EIQLICYHAR EIFLNQPTLL RLQAPIKVVG 300
  301 DVHGQFNDLL RILKLSGVPS DTNYLFLGDY VDRGKNSLET ILLLLCYKIK YKDNFFMLRG 360
  361 NHESANVTKM YGFYDECKRR LSSKVWKMFV DVFNTLPLAA IIQDKIFCVH GGISPDLHDM 420
  421 KQIEKVARPT DIPESGLVTD LLWSDPDPQV TDWSENDRGV SYTFSKRNVL DFCAKFKFDL 480
  481 ILRGHMVVED GYEFFARKKF VTIFSAPNYC GEFHNWGAVM SVTTGMMCSF ELLKPRALKN 540
  541 KKKLYKTKV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) PPQ1 SDS22

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YPI1 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PPQ1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] deduced N/A No confident structure predictions are available.
    2 View Details [73..231] PSI-BLAST 32.39794 Protein phosphatase 5
    3 View Details [232..549] PSI-BLAST 1302.0 Protein phosphatase-1 (PP-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.22791066554607 bayes_pls_golite062009
  • phosphatase activity
    		•  6.21754026490199 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.00674602220619 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  5.86006406811342 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.18314342778634 bayes_pls_golite062009
  • binding
    		•  2.71974493738804 bayes_pls_golite062009
  • protein binding
    		•  2.67835748923436 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.36571535004008 bayes_pls_golite062009
  • DNA binding
    		•  1.71381351716702 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.62783430593918 bayes_pls_golite062009
  • transcription factor activity
    		•  1.01338808398786 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.967526235944614 bayes_pls_golite062009
  • acetylglucosaminyltransferase activity
    		•  0.78476205818302 bayes_pls_golite062009
  • receptor activity
    		•  0.765633559982614 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.679771252160931 bayes_pls_golite062009
  • signal transducer activity
    		•  0.679771252160931 bayes_pls_golite062009
  • hydrolase activity
    		•  0.619711232527193 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.606264963283666 bayes_pls_golite062009
  • transcription factor binding
    		•  0.518146612491969 bayes_pls_golite062009
  • RNA binding
    		•  0.497066934302855 bayes_pls_golite062009
  • signal sequence binding
    		•  0.49295886046194 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.370858685623455 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30464889749774 bayes_pls_golite062009
  • peptide binding
    		•  0.280393897104229 bayes_pls_golite062009
  • transferase activity
    		•  0.127854220687373 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.116119418380222 bayes_pls_golite062009
  • ligase activity
    		•  0.102007806594868 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0593768116971065 bayes_pls_golite062009
  • acetyltransferase activity
    		•  0.0233291331884218 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • kinase activity
    		•  0.671153901928902 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.653838048261886 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.632790145692488 bayes_pls_golite062009
  • signal transducer activity
    		•  0.632790145692488 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.574603802558181 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • protein kinase activity
    		•  0.375779843321939 bayes_pls_golite062009
  • transferase activity
    		•  0.319184977255763 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.126411744957937 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle