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Protein Overview: RRD2

General Information:
Name(s) found: RRD2 / YPL152W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 358 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TASLink to PubMed article]
    cell fraction [IDALink to PubMed article]
    Biological Process: response to osmotic stress [IGILink to PubMed article][IMPLink to PubMed article]
    mitotic spindle organization in nucleus [IMPLink to PubMed article]
    Molecular Function: protein phosphatase type 2A regulator activity [IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPEKRLLTP DDMKLWEESP TRAHFTKFII DLAESVKGHE NSQYKEPISE SINSMMNLLS  60
   61 QIKDITQKHP VIKDADSSRF GKVEFRDFYD EVSRNSRKIL RSEFPSLTDE QLEQLSIYLD 120
  121 ESWGNKRRID YGSGHELNFM CLLYGLYSYG IFNLSNDSTN LVLKVFIEYL KIMRILETKY 180
  181 WLEPAGSHGV WGLDDYHFLP FLFGAFQLTT HKHLKPISIH NNELVEMFAH RYLYFGCIAF 240
  241 INKVKSSASL RWHSPMLDDI SGVKTWSKVA EGMIKMYKAE VLSKLPIMQH FYFSEFLPCP 300
  301 DGVSPPRGHI HDGTDKDDEC NFEGHVHTTW GDCCGIKLPS AIAATEMNKK HHKPIPFD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC55 PPH22 RRD2 RTS1 TPD3 ZDS1
    View Details Krogan NJ, et al. (2006) CDC55 FIR1 PHR1 PPH21 PPH22 RRD2 TPD3 YRR1 ZDS1 ZDS2
    View Details Gavin AC, et al. (2002) BLM10 CDC55 CIN1 ERG13 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 KAP95 KEL1 LTE1 MYO5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RRD2 RTS1 RTS3 SCL1 SET3 SIF2 SNT1 SRP1 TDH2 TDH3 TEF4 TPD3 YBL104C YOR1 YRA1 ZDS1 ZDS2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MPE1 RRD2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RRD2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..358] Pfam 194.744727 Phosphotyrosyl phosphate activator (PTPA) protein No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein phosphatase 2A binding
    		•  8.91440374532471 bayes_pls_golite062009
  • protein phosphatase type 2A regulator activity
    		•  8.6639960888548 bayes_pls_golite062009
  • phosphatase activator activity
    		•  8.3056988507343 bayes_pls_golite062009
  • protein tyrosine phosphatase activator activity
    		•  8.25208483660706 bayes_pls_golite062009
  • phosphatase regulator activity
    		•  6.19500533578098 bayes_pls_golite062009
  • protein phosphatase regulator activity
    		•  6.15684302555811 bayes_pls_golite062009
  • hydrolase activity
    		•  2.45059495047304 bayes_pls_golite062009
  • protein phosphatase binding
    		•  2.00937322119814 bayes_pls_golite062009
  • phosphatase binding
    		•  1.91058768875586 bayes_pls_golite062009
  • binding
    		•  1.8791829282582 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.7601888817048 bayes_pls_golite062009
  • protein binding
    		•  1.54296590753075 bayes_pls_golite062009
  • enzyme binding
    		•  0.93814259527019 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.877491580866805 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.382201469725949 bayes_pls_golite062009
  • catalytic activity
    		•  0.262417313750414 bayes_pls_golite062009
  • receptor binding
    		•  0.23629695620438 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.0723700055105033 bayes_pls_golite062009
  • ATP binding
    		•  0.00395016899365508 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle