Protein Overview: MRS2

General Information:
Name(s) found:	MRS2 / YOR334W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324909\|ref\|NP_014979.1\| Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; Mrs2p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S62064 mitochondrial RNA splicing protein MRS2 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1709102\|sp\|Q01926.2\|MRS2_YEAST RecName: Full=Magnesium transporter MRS2, mitochondrial; AltName: Full=RNA-splicing protein MRS2; Flags: Precursor [NCBI NR] gi\|1420727\|emb\|CAA99656.1\| MRS2 [Saccharomyces cerevisiae] [NCBI NR] gi\|1163068\|emb\|CAA89979.1\| MRS2 [Saccharomyces cerevisiae] [NCBI NR] Magnesium transporter MRS2, mitochondrial OS=Saccharomyces cerevisiae GN=MRS2 PE=1 SV=2 [Swiss-Prot] MRS2 Mitochondrial inner membrane Mg(2+) channel, suport correct Mg(2+) level for splicing of group II introns [mips] Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns [SGD] (Q01926) RNA splicing protein MRS2, mitochondrial precursor [4932.FASTACCERV.txt] Chr XV from 944589-946001 [hmr_yeast5_DM3-1_pombe.fasta] Chr XV from 944588-946000 [yeastorf3.fasta] MRS2, Chr XV from 944588-946000 [yeast_orfs2] MRS2 SGDID:S0005861, Chr XV from 944591-946003, Verified ORF [yeastflysequest.fasta] Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns [Saccharomyces cerevisiae]gi\|1420727\|emb\|CAA99656.1\| MRS2 [Saccharomyces cerevi [nrdb_11152004_Chlamydomonas] MRS2 SGDID:S000005861, Chr XV from 944591-946003, Verified ORF, "Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] MRS2 SGDID:S000005861, Chr XV from 944593-946005, Verified ORF, "Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns" [yeast-contam.fasta] MRS2 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; Mrs2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Magnesium transporter MRS2, mitochondrial precursor (RNA-splicing protein MRS2) [nr-271106-contam.fasta] [chemostatdb.fasta] Magnesium transporter MRS2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRS2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MRS2 SGDID:S000005861, Chr XV from 944596-946008, Genome Release 64-1-1, Verified ORF, "Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns" [yeast-030211-contam.fasta] MRS2 SGDID:S000005861, Chr XV from 944596-946008, Genome Release 64-2-1, Verified ORF, "Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA" [20141208_orf_trans.fasta] YOR334W SGDID:S000005861, Chr XV from 944596-946008, Genome Release 64-1-1, Verified ORF, "Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	470 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial inner membrane [IDA]
Biological Process:	Group II intron splicing [IMP] mitochondrial magnesium ion transport [IDA][IGI][IMP][ISS]
Molecular Function:	magnesium ion transmembrane transporter activity [IDA][IGI][IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRRLLVRSI SCFQPLSRIT FGRPNTPFLR KYADTSTAAN TNSTILRKQL LSLKPISASD  60
   61 SLFISCTVFN SKGNIISMSE KFPKWSFLTE HSLFPRDLRK IDNSSIDIIP TIMCKPNCIV 120
  121 INLLHIKALI ERDKVYVFDT TNPSAAAKLS VLMYDLESKL SSTKNNSQFY EHRALESIFI 180
  181 NVMSALETDF KLHSQICIQI LNDLENEVNR LKLRHLLIKS KDLTLFYQKT LLIRDLLDEL 240
  241 LENDDDLANM YLTVKKSPKD NFSDLEMLIE TYYTQCDEYV QQSESLIQDI KSTEEIVNII 300
  301 LDANRNSLML LELKVTIYTL GFTVASVLPA FYGMNLKNFI EESEWGFTSV AVFSIVSALY 360
  361 ITKKNFNSLR SVTKMTMYPN SPANSSVYPK TSASIALTNK LKRRRKWWKS TKQRLGVLLY 420
  421 GSSYTNKANL SNNKINKGFS KVKKFNMEND IKNKQNRDMI WKWLIEDKKN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		BI4 CBP6 MRS1 MRS2 MRS3 MRS4 MSS1 MSS116 MSS18 MTF2 NAM2 PET54 TIM10
View Details	Krogan NJ, et al. (2006)		MRS2 SUE1 YIL169C
View Details	Qiu et al. (2008)		ATP6 ATP8 CCS1 LPE10 MNR2 MRS2 MRS3 MTM1 ODC1 OLI1 PET54

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

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	BAIT	PREY	HITS	PUBLICATION
View Screen	PRP16	MRS2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MRS2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..156]	MSA	2.248996	View MSA. No confident structure predictions are available.
2	View Details	[157..379]	MSA	14.298996	View MSA. No confident structure predictions are available.
3	View Details	[380..470]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	pre 2.0c	PSIPRED	pre v2.61
SignalP	pre 3.0	COILS	1999
DISOPRED	pre v0.2	NCBI nr	circa 2005
PSI-BLAST	~2.2.10	FFAS	ffas
PDB	~2005	Pfam	16
HMMER	2.3.1