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Protein Overview: MOD5

General Information:
Name(s) found: MOD5 / YOR274W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 428 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    cytosol [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: tRNA modification [IMPLink to PubMed article]
    Molecular Function: tRNA isopentenyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKGPLKGCL NMSKKVIVIA GTTGVGKSQL SIQLAQKFNG EVINSDSMQV YKDIPIITNK  60
   61 HPLQEREGIP HHVMNHVDWS EEYYSHRFET ECMNAIEDIH RRGKIPIVVG GTHYYLQTLF 120
  121 NKRVDTKSSE RKLTRKQLDI LESTDPDVIY NTLVKCDPDI ATKYHPNDYR RVQRMLEIYY 180
  181 KTGKKPSETF NEQKITLKFD TLFLWLYSKP EPLFQRLDDR VDDMLERGAL QEIKQLYEYY 240
  241 SQNKFTPEQC ENGVWQVIGF KEFLPWLTGK TDDNTVKLED CIERMKTRTR QYAKRQVKWI 300
  301 KKMLIPDIKG DIYLLDATDL SQWDTNASQR AIAISNDFIS NRPIKQERAP KALEELLSKG 360
  361 ETTMKKLDDW THYTCNVCRN ADGKNVVAIG EKYWKIHLGS RRHKSNLKRN TRQADFEKWK 420
  421 INKKETVE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MOD5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] ORFEUS 14.3 Replication factor C
    2 View Details [129..195] ORFEUS 14.3 Replication factor C
    3 View Details [196..305] ORFEUS 14.3 Replication factor C
    4 View Details [306..428] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  3.37529385176635 bayes_pls_golite062009
  • DNA binding
    		•  3.3049326844117 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.24981360535232 bayes_pls_golite062009
  • binding
    		•  2.79894364685962 bayes_pls_golite062009
  • transcription factor activity
    		•  2.44389510173662 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.57041104288348 bayes_pls_golite062009
  • transcription activator activity
    		•  1.20323819132961 bayes_pls_golite062009
  • protein binding
    		•  0.852654490075478 bayes_pls_golite062009
  • RNA binding
    		•  0.84315767580466 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.732558534458316 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.686318575498149 bayes_pls_golite062009
  • chromatin binding
    		•  0.626365497850853 bayes_pls_golite062009
  • transcription factor binding
    		•  0.515821187939278 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.200483461579207 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.113925660147477 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0855506955761403 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle