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Protein Overview: AKR2

General Information:
Name(s) found: AKR2 / YOR034C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 749 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: protein amino acid palmitoylation [ISSLink to PubMed article]
    endocytosis [ISSLink to PubMed article]
    Molecular Function: protein-cysteine S-palmitoleyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSMSIIDDE NVKKTSNGAA VVTDVAQHAV SDSDNNKAQL LGDGSNTEYV VDIFIEAAKD  60
   61 GDLKVVKDVV ESGAVDINND RIDELSGLHW ACINNRFSVA KFLLLRGANP NQAAGPGGAT 120
  121 ALHWAARYGN IYIVDLLLKH GADPTLKDEQ GLNIMHFSVY SSNILLVVYV LYFVVNNNDN 180
  181 VDIDSKDNNN RTPLLWAAYQ GDFLTVELLL KFGSTVAWTD NRGFNALHCA LVGGDQRVIC 240
  241 DLILSGANFY ERNNQKQDCF DLAEGMGTKS LFEQALQHHG YDRLGNQKDK LFKKSSHAQF 300
  301 TIFLSPFLLM VYIYLISLVL SPVLAIMLSL LVTVVMVNTL KKFVLPCLPR KNTYKVSLTR 360
  361 TPFFSGLFLS TFCFLIYIWT KKLYPYSVSD YTMKNVQFLV TSFLTVVLFL RLVRSDPGCL 420
  421 KTDDSLTSIQ ETIKQLIDLG KFDRENFCVE TLERKPLRSK YSFFSGALVA RYDHYCPWIY 480
  481 NDVGLKNHKL FVFFAVTVQY HMFLFMWLCL AYFKKTNYIY EQVEEYARCA LLKNETLCKG 540
  541 SNYDPSTFFL FIWISVNFIW LGAMLIVQFF QILKGITTPE LFILIKEEHK AKFINLIPFE 600
  601 NSIYTSESKG VEDSDMIPEG PSATTITHTI SIDGLEPRNR RRAILSACFS MMGINQWLVT 660
  661 IKEIVGITHI LHGQVPQQHH SSLLRSFLVT NHWKTNLTDF WLNSDVTAPL WQRFFYSSDT 720
  721 SKAMLGGTEV DYYELYEYPA REGEVLRPN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YPT35 AKR2 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data AKR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] deduced N/A No confident structure predictions are available.
    2 View Details [81..184] PSI-BLAST 104.38764 bcl-3
    3 View Details [185..337] PSI-BLAST 104.38764 bcl-3
    4 View Details [338..637] MSA 47.213989 View MSA. No confident structure predictions are available.
    5 View Details [638..749] MSA 1.018963 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.17983095277661 bayes_pls_golite062009
  • transporter activity
    		•  1.19000052859754 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.02570255606772 bayes_pls_golite062009
  • receptor activity
    		•  0.794712986057462 bayes_pls_golite062009
  • signal transducer activity
    		•  0.789486768149117 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.789486768149117 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.694785132815586 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.581121752453591 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.428839878681413 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.304692936026767 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.240863793118641 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.171334135216535 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein binding
    		•  1.29825545184374 bayes_pls_golite062009
  • transporter activity
    		•  1.29200212594063 bayes_pls_golite062009
  • binding
    		•  1.10226396973253 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08174821699506 bayes_pls_golite062009
  • catalytic activity
    		•  0.481338897251745 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.304549276964021 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.0736199735231255 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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