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View Structure Prediction Details

Protein: AKR2
Organism: Saccharomyces cerevisiae
Length: 749 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AKR2.

Description E-value Query
Range		 Subject
Range
AKR2 - Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransfer...
AKR2_YEAST - Probable palmitoyltransferase AKR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AKR2 ...
 0.0 [1..749] [1..749]
gi|4589536 - gi|4589536|dbj|BAA76790.1| KIAA0946 protein [Homo sapiens]
 0.0 [57..618] [99..632]
SPAC2F7.10 - palmitoyltransferase
AKR1_SCHPO - Palmitoyltransferase akr1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=akr1 PE=3 SV=1
 0.0 [54..619] [4..567]
gi|220943582 - gi|220943582|gb|ACL84334.1| Hip14-PA [synthetic construct]
FBpp0305754, Hip... - The gene Huntingtin-interacting protein 14 is referred to in FlyBase by the symbol Dmel\Hip14 (CG601...
 2.0E-98 [57..619] [52..587]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 4.0E-97 [1..411] [219..623]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 9.0E-97 [1..411] [219..623]

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Predicted Domain #1
Region A:
Residues: [1-80] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSMSIIDDE NVKKTSNGAA VVTDVAQHAV SDSDNNKAQL LGDGSNTEYV VDIFIEAAKD  60
   61 GDLKVVKDVV ESGAVDINND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
protein binding 2.69918165732603 bayes_pls_golite062009
binding 2.17983095277661 bayes_pls_golite062009
transporter activity 1.19000052859754 bayes_pls_golite062009
transmembrane transporter activity 1.02570255606772 bayes_pls_golite062009
receptor activity 0.794712986057462 bayes_pls_golite062009
signal transducer activity 0.789486768149117 bayes_pls_golite062009
molecular transducer activity 0.789486768149117 bayes_pls_golite062009
transmembrane receptor activity 0.694785132815586 bayes_pls_golite062009
substrate-specific transporter activity 0.581121752453591 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.428839878681413 bayes_pls_golite062009
transcription regulator activity 0.304692936026767 bayes_pls_golite062009
ion transmembrane transporter activity 0.240863793118641 bayes_pls_golite062009
nucleic acid binding 0.171334135216535 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [81-184] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIDELSGLHW ACINNRFSVA KFLLLRGANP NQAAGPGGAT ALHWAARYGN IYIVDLLLKH  60
   61 GADPTLKDEQ GLNIMHFSVY SSNILLVVYV LYFVVNNNDN VDID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 104.38764
Match: 1k1aA_
Description: bcl-3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein binding 1.29825545184374 bayes_pls_golite062009
transporter activity 1.29200212594063 bayes_pls_golite062009
binding 1.10226396973253 bayes_pls_golite062009
transmembrane transporter activity 1.08174821699506 bayes_pls_golite062009
catalytic activity 0.481338897251745 bayes_pls_golite062009
active transmembrane transporter activity 0.304549276964021 bayes_pls_golite062009
primary active transmembrane transporter activity 0.0736199735231255 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [185-337] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKDNNNRTPL LWAAYQGDFL TVELLLKFGS TVAWTDNRGF NALHCALVGG DQRVICDLIL  60
   61 SGANFYERNN QKQDCFDLAE GMGTKSLFEQ ALQHHGYDRL GNQKDKLFKK SSHAQFTIFL 120
  121 SPFLLMVYIY LISLVLSPVL AIMLSLLVTV VMV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 104.38764
Match: 1k1aA_
Description: bcl-3
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [338-637] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTLKKFVLPC LPRKNTYKVS LTRTPFFSGL FLSTFCFLIY IWTKKLYPYS VSDYTMKNVQ  60
   61 FLVTSFLTVV LFLRLVRSDP GCLKTDDSLT SIQETIKQLI DLGKFDRENF CVETLERKPL 120
  121 RSKYSFFSGA LVARYDHYCP WIYNDVGLKN HKLFVFFAVT VQYHMFLFMW LCLAYFKKTN 180
  181 YIYEQVEEYA RCALLKNETL CKGSNYDPST FFLFIWISVN FIWLGAMLIV QFFQILKGIT 240
  241 TPELFILIKE EHKAKFINLI PFENSIYTSE SKGVEDSDMI PEGPSATTIT HTISIDGLEP 300
  301

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [638-749] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNRRRAILSA CFSMMGINQW LVTIKEIVGI THILHGQVPQ QHHSSLLRSF LVTNHWKTNL  60
   61 TDFWLNSDVT APLWQRFFYS SDTSKAMLGG TEVDYYELYE YPAREGEVLR PN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle