| Protein: | AKR2 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 749 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AKR2.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..749] | [1..749] |
|
|
0.0 | [57..618] | [99..632] |
|
|
0.0 | [54..619] | [4..567] |
|
|
2.0E-98 | [57..619] | [52..587] |
|
|
4.0E-97 | [1..411] | [219..623] |
|
|
9.0E-97 | [1..411] | [219..623] |
|
Region A: Residues: [1-80] |
1 11 21 31 41 51
| | | | | |
1 MTSMSIIDDE NVKKTSNGAA VVTDVAQHAV SDSDNNKAQL LGDGSNTEYV VDIFIEAAKD 60
61 GDLKVVKDVV ESGAVDINND
|
| Detection Method: |  |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.699 | a.77.1 | DEATH domain |
| View | Download | 0.692 | a.77.1 | DEATH domain |
| View | Download | 0.622 | a.163.1 | Crustacean CHH/MIH/GIH neurohormone |
| View | Download | 0.394 | a.77.1 | DEATH domain |
| View | Download | 0.354 | d.120.1 | Cytochrome b5 |
| View | Download | 0.347 | a.37.1 | A DNA-binding domain in eukaryotic transcription factors |
| View | Download | 0.318 | a.61.1 | Retroviral matrix proteins |
| View | Download | 0.311 | a.50.1 | Anaphylotoxins (complement system) |
| View | Download | 0.306 | a.60.11 | Hypothetical protein YjbJ |
| View | Download | 0.306 | d.58.17 | Metal-binding domain |
| View | Download | 0.277 | a.8.1 | Bacterial immunoglobulin/albumin-binding domains |
| View | Download | 0.266 | d.58.40 | D-ribose-5-phosphate isomerase (RpiA), lid domain |
| View | Download | 0.263 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.256 | a.61.1 | Retroviral matrix proteins |
| View | Download | 0.251 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.249 | d.58.1 | 4Fe-4S ferredoxins |
| View | Download | 0.242 | a.39.1 | EF-hand |
| View | Download | 0.241 | d.68.3 | SirA-like |
| View | Download | 0.239 | d.68.6 | DNA-binding protein Sso10b (AlbA) |
| View | Download | 0.233 | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.216 | d.58.1 | 4Fe-4S ferredoxins |
| View | Download | 0.207 | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.206 | d.58.12 | eEF-1beta-like |
| View | Download | 0.205 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.205 | d.58.3 | Protease propeptides/inhibitors |
| View | Download | 0.204 | a.85.1 | Hemocyanin, N-terminal domain |
| View | Download | 0.204 | a.60.3 | C-terminal domain of RNA polymerase alpha subunit |
| View | Download | 0.203 | a.64.2 | Bacteriocin AS-48 |
| View | Download | 0.200 | d.95.2 | Homing endonucleases |
| Term | Confidence | Notes |
| protein binding | 2.69918165732603 | bayes_pls_golite062009 |
| binding | 2.17983095277661 | bayes_pls_golite062009 |
| transporter activity | 1.19000052859754 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.02570255606772 | bayes_pls_golite062009 |
| receptor activity | 0.794712986057462 | bayes_pls_golite062009 |
| signal transducer activity | 0.789486768149117 | bayes_pls_golite062009 |
| molecular transducer activity | 0.789486768149117 | bayes_pls_golite062009 |
| transmembrane receptor activity | 0.694785132815586 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.581121752453591 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.428839878681413 | bayes_pls_golite062009 |
| transcription regulator activity | 0.304692936026767 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.240863793118641 | bayes_pls_golite062009 |
| nucleic acid binding | 0.171334135216535 | bayes_pls_golite062009 |
|
Region A: Residues: [81-184] |
1 11 21 31 41 51
| | | | | |
1 RIDELSGLHW ACINNRFSVA KFLLLRGANP NQAAGPGGAT ALHWAARYGN IYIVDLLLKH 60
61 GADPTLKDEQ GLNIMHFSVY SSNILLVVYV LYFVVNNNDN VDID
|
| Detection Method: | |
| Confidence: | 104.38764 |
| Match: | 1k1aA_ |
| Description: | bcl-3 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein binding | 1.29825545184374 | bayes_pls_golite062009 |
| transporter activity | 1.29200212594063 | bayes_pls_golite062009 |
| binding | 1.10226396973253 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.08174821699506 | bayes_pls_golite062009 |
| catalytic activity | 0.481338897251745 | bayes_pls_golite062009 |
| active transmembrane transporter activity | 0.304549276964021 | bayes_pls_golite062009 |
| primary active transmembrane transporter activity | 0.0736199735231255 | bayes_pls_golite062009 |
|
Region A: Residues: [185-337] |
1 11 21 31 41 51
| | | | | |
1 SKDNNNRTPL LWAAYQGDFL TVELLLKFGS TVAWTDNRGF NALHCALVGG DQRVICDLIL 60
61 SGANFYERNN QKQDCFDLAE GMGTKSLFEQ ALQHHGYDRL GNQKDKLFKK SSHAQFTIFL 120
121 SPFLLMVYIY LISLVLSPVL AIMLSLLVTV VMV
|
| Detection Method: | |
| Confidence: | 104.38764 |
| Match: | 1k1aA_ |
| Description: | bcl-3 |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [338-637] |
1 11 21 31 41 51
| | | | | |
1 NTLKKFVLPC LPRKNTYKVS LTRTPFFSGL FLSTFCFLIY IWTKKLYPYS VSDYTMKNVQ 60
61 FLVTSFLTVV LFLRLVRSDP GCLKTDDSLT SIQETIKQLI DLGKFDRENF CVETLERKPL 120
121 RSKYSFFSGA LVARYDHYCP WIYNDVGLKN HKLFVFFAVT VQYHMFLFMW LCLAYFKKTN 180
181 YIYEQVEEYA RCALLKNETL CKGSNYDPST FFLFIWISVN FIWLGAMLIV QFFQILKGIT 240
241 TPELFILIKE EHKAKFINLI PFENSIYTSE SKGVEDSDMI PEGPSATTIT HTISIDGLEP 300
301
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.396 | N/A | N/A | d.95.2 | Homing endonucleases |
| View | Download | 0.373 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.360 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.349 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.344 | N/A | N/A | a.60.2 | RuvA domain 2-like |
|
Region A: Residues: [638-749] |
1 11 21 31 41 51
| | | | | |
1 RNRRRAILSA CFSMMGINQW LVTIKEIVGI THILHGQVPQ QHHSSLLRSF LVTNHWKTNL 60
61 TDFWLNSDVT APLWQRFFYS SDTSKAMLGG TEVDYYELYE YPAREGEVLR PN
|
| Detection Method: | |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.396 | N/A | N/A | d.95.2 | Homing endonucleases |
| View | Download | 0.373 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.360 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.349 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.344 | N/A | N/A | a.60.2 | RuvA domain 2-like |
| View | Download | 0.331 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.320 | N/A | N/A | a.36.1 | Signal peptide-binding domain |
| View | Download | 0.317 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.299 | N/A | N/A | b.60.1 | Lipocalins |
| View | Download | 0.282 | N/A | N/A | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.276 | N/A | N/A | a.60.6 | DNA polymerase beta, N-terminal domain-like |
| View | Download | 0.255 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.222 | N/A | N/A | d.92.1 | Metalloproteases ("zincins"), catalytic domain |
| View | Download | 0.221 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.205 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
