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Protein Overview: CPR8

General Information:
Name(s) found: CPR8 / YNR028W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 308 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: peptidyl-prolyl cis-trans isomerase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSFFLYLYV AFMFSCITAL PLPVDNKRAS SDSLDLKKKY APDPPITHNV NIGIVFTDPE  60
   61 SSEEAGRLIT IDLYGTMVPK TVMTFCQYVD SVKDRLASRH SYSPERDFDK ILPNGAIEGS 120
  121 SVSSSSIEET EMLAPKLPEE NHSLIHDRPG RVSMIKDDKG LKFIIETSET PLEGESVVFG 180
  181 QVTAGLKDLM DKLANVKTDE NGKPEQPITI GYISSQEHRI QHAKEAHEKY LQRLQDYQNG 240
  241 DLEKGITLKN YLYQGSQRKL EDAKYNQLHH PLPKIMLGIS VLLLFYVLAK YRKRIFNRSS 300
  301 KIVSIRED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CPR8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..253] PSI-BLAST 161.522879 Cyclophilin (eukaryotic)
    2 View Details [254..308] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  2.94609837984526 bayes_pls_golite062009
  • mRNA binding
    		•  1.45537055700871 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.26149030245805 bayes_pls_golite062009
  • binding
    		•  1.0658238478447 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  1.05326644345172 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  0.985752998974367 bayes_pls_golite062009
  • DNA binding
    		•  0.9531600253493 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.939772862764466 bayes_pls_golite062009
  • catalytic activity
    		•  0.748655649755714 bayes_pls_golite062009
  • procollagen-proline 4-dioxygenase activity
    		•  0.482467028485988 bayes_pls_golite062009
  • procollagen-proline dioxygenase activity
    		•  0.482467028485988 bayes_pls_golite062009
  • peptidyl-proline dioxygenase activity
    		•  0.482467028485988 bayes_pls_golite062009
  • peptidyl-proline 4-dioxygenase activity
    		•  0.482467028485988 bayes_pls_golite062009
  • transcription factor activity
    		•  0.374364600772076 bayes_pls_golite062009
  • protein binding
    		•  0.213899354841013 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0640969351727338 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle