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Protein Overview: CAF120

General Information:
Name(s) found: CAF120 / YNL278W [SGD]
Description(s) found:
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  • gi|6324051|ref|NP_014121.1| Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; Caf120p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S63252 hypothetical protein YNL278w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1730643|sp|P53836.1|CA120_YEAST RecName: Full=CCR4-NOT transcriptional complex subunit CAF120; AltName: Full=120 kDa CCR4-associated factor [NCBI NR]
  • gi|1302347|emb|CAA96190.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Uncharacterized protein YNL278W - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot]
  • CCR4-NOT transcriptional complex subunit CAF120 OS=Saccharomyces cerevisiae GN=CAF120 PE=1 SV=1 [Swiss-Prot]
  • CAF120 CCR4 Associated Factor 120 kDa [mips]
  • Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation [SGD]
  • Chr XIV from 113269-116451 [yeastorf3.fasta]
  • (P53836) Hypothetical 118.3 kDa protein in ERG24-MET2 intergenic region [4932.FASTACCERV.txt]
  • CAF120, Chr XIV from 113269-116451 [yeast_orfs2]
  • CAF120 SGDID:S0005222, Chr XIV from 113269-116451, Verified ORF [yeastflysequest.fasta]
  • CCR4 Associated Factor 120 kDa [Saccharomyces cerevisiae]gi|1302347|emb|CAA96190.1| unnamed protein product [Saccharomyces cerevisiae]gi|1730643|sp|P53836|YN18_YEAST Hypothetical 118.3 kDa protein in ERG24-MET2 intergenic regiongi|2131952|pir||S63252 h [nrdb_11152004_Chlamydomonas]
  • CAF120 SGDID:S000005222, Chr XIV from 113271-116453, Verified ORF, "Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation; Caf120p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Hypothetical 118.3 kDa protein in ERG24-MET2 intergenic region [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • CCR4-NOT transcriptional complex subunit CAF120 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CAF120 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • CAF120 SGDID:S000005222, Chr XIV from 113271-116453, Genome Release 64-1-1, Verified ORF, "Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation" [yeast-030211-contam.fasta]
  • CAF120 SGDID:S000005222, Chr XIV from 113271-116453, Genome Release 64-2-1, Verified ORF, "Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YNL278W SGDID:S000005222, Chr XIV from 113271-116453, Genome Release 64-1-1, Verified ORF, "Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1060 amino acids

    Gene Ontology:
    Cellular Component: CCR4-NOT complex [IPILink to PubMed article]
    Biological Process: regulation of transcription from RNA polymerase II promoter [IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIFSGDNKV VDSLASNPGL MSPSNFGGDF GSRLKVNVTS KKKLNDSSPT SPMESSPVSP  60
   61 ELVPILTLLN AHTHRRYHEG VFLILQDLNN NGTHAARKWK DVYGVLLGTQ LALWDAKELA 120
  121 EFTDPSCPVS EKKLKEVASK PTYINLTDAT LRTLDNSDNI VMECGKNLTN ALVVSTTLKN 180
  181 RYFLQFGNKE SFNAWNSAIR LCLYECSSLQ EAYTGAFISS RGAKLGDIRI LLTNRKYDYK 240
  241 DWVSVRFGAG MPWKRCYAVI SQSSSKKKGH FGEINLYEND KKVKKNHAMA TIVEAKALYA 300
  301 VYPSSPKLID SSTIIKVVGS VKFEKKESAQ EKDVFIMPEK HQAVPSYDTI IRFLIPAMDT 360
  361 FKLYGRPEKL LSSKNDPHSL LFGLPVLPHI YYLEVEDLLP LTNSVSSLHW SNNEWKEHIS 420
  421 DILQRKIAQG YCGCNSTSNI TSPLPSPFLG SADLFERADG VLSPKLSYGS KSSSNNSSKN 480
  481 SLPKRERVKL SSSSEQDLNN SDSPSIKRKS PPLVISESPH KVHTPTDASF RTRVTEGSPY 540
  541 AKQRHPKPFA SSVNDSPSDR AKSRTVPYNN NDRKATTPEK FERGETSCGK NVDESLEKVR 600
  601 NMKLEIPESN FDKFMTDKNL LSVDSKCSNE KKLSVESDLS AIYEKYSNGP FGHTEGLNGS 660
  661 SDETYLRFQR ASVHSESNYN SRKSFTPSDF SNGNEEEHAV LQELNSLTQR INELGMESIN 720
  721 SNSDSDRING SYSQVDFGNN NDEDDMNLFD PDFMAQDQLR AEERDYNKDD RTPLAKVPAA 780
  781 FQSTGLGITP DDDIERQYIT EHRSRHEVPK RSPEKPSNPL EIGNPYAKPG TRLNTTHTHS 840
  841 KTDRSITPQR GQPVPSGQQI SSYVQPANIN SPNKMYGANN SAMGSPRNPK TRAPPGPYNQ 900
  901 GWNNRPSPSN IYQRPHPSDT QPQAYHLPGN PYSTGNRPNM QAQYHPQQVP MPILQQPNRP 960
  961 YQPYAMNTHM GSPGGYAGAA PPFQPANVNY NTRPQQPWPT PNSPSAHYRP PPNLNQPQNG1020
 1021 SAGYYRPPAP QLQNSQARPQ KKDGFSQFMP SATTKNPYAQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) CAF120 CPR6 QNS1 TRR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CAF120 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] deduced N/A No confident structure predictions are available.
    2 View Details [76..232] Pfam 8.585027 PH domain No confident structure predictions are available.
    3 View Details [233..331] deduced N/A No confident structure predictions are available.
    4 View Details [332..1060] MSA 37.355997 View MSA. No confident structure predictions are available.
    5 View Details [792..865] MSA 1.250991 View MSA. No confident structure predictions are available.
    6 View Details [866..1060] MSA 5.247997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.16245771986829 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.13588211069605 bayes_pls_golite062009
  • protein binding
    		•  1.95763087285706 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.89560227697295 bayes_pls_golite062009
  • DNA binding
    		•  1.80618207914839 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.7376876470681 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.698266875418824 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle