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Protein Overview: GCD10

General Information:
Name(s) found: GCD10 / YNL062C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 478 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    translational initiation [TASLink to PubMed article]
    tRNA methylation [IDALink to PubMed article]
    Molecular Function: tRNA (adenine-N1-)-methyltransferase activity [IDALink to PubMed article][IPILink to PubMed article]
    tRNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNALTTIDFN QHVIVRLPSK NYKIVELKPN TSVSLGKFGA FEVNDIIGYP FGLTFEIYYD  60
   61 GEEVSSDENR DSKPKNKIPI GKVRLLSQEI KDVNNDKDDG QSEPPLSIKE KSVSLELSSI 120
  121 DSSATNQNLV NMGSKAQELT VEEIEKMKQE SLSSKEIIDK IIKSHKSFHN KTVYSQEKYV 180
  181 NRKKQKFAKY FTVEYLSSSN LLQFLIDKGD IQRVLDMSQE SMGMLLNLAN IQSEGNYLCM 240
  241 DETGGLLVYF LLERMFGGDN ESKSKGKVIV IHENEHANLD LLKFANYSEK FIKEHVHTIS 300
  301 LLDFFEPPTL QEIQSRFTPL PKEEARALKG GKKNSYYRKL RWYNTQWQIL ELTGEFLYDG 360
  361 LVMATTLHLP TLVPKLAEKI HGSRPIVCYG QFKETLLELA HTLYSDLRFL APSILETRCR 420
  421 PYQSIRGKLH PLMTMKGGGG YLMWCHRVIP APEPVSENAT AADSSEKLAE HGAKKQKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GCD10 GCD14
    View Details (MIPS) Mewes HW, et al. (2004) GCD10 NIP1 PRT1 RPG1 SUI1 TIF34 TIF35
    View Details Krogan NJ, et al. (2006) GCD10 GCD14
    View Details Qiu et al. (2008) GCD10 GCD14 NCL1 TRM1 TRM10 TRM8 TRM82

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GCD10 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..324] MSA 1.009926 View MSA. No confident structure predictions are available.
    2 View Details [325..478] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  8.35052619058198 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  8.35052619058198 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  7.44275105246879 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  6.5439125367639 bayes_pls_golite062009
  • methyltransferase activity
    		•  3.68431317301075 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.64494850793256 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  3.60853685152199 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  3.51986359093355 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  2.666651371662 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  2.63941856307703 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  1.99340565364513 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  1.99340565364513 bayes_pls_golite062009
  • transferase activity
    		•  1.97261773840408 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  1.85380504590369 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  1.77527486495102 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  1.64765900536818 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  1.54257365884902 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  1.54257365884902 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  1.27753381141602 bayes_pls_golite062009
  • catalytic activity
    		•  1.16970557486814 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.953292160159369 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.750060357052574 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  0.735680462496249 bayes_pls_golite062009
  • DNA binding
    		•  0.728534001468705 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  0.51222176401398 bayes_pls_golite062009
  • binding
    		•  0.486361285495359 bayes_pls_golite062009
  • RNA binding
    		•  0.413112349791396 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.286806504860858 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  0.113328595762489 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.0390774859535424 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle