Protein Overview: YIM1

General Information:
Name(s) found:	YIM1 / YMR152W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|732169\|sp\|P28625.2\|YM27_YEAST RecName: Full=Uncharacterized protein YMR152W [NCBI NR] gi\|6323801\|ref\|NP_013872.1\| Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Yim1p [Saccharomyces cerevisiae] [NCBI NR] gi\|45270728\|gb\|AAS56745.1\| YMR152W [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S50409 hypothetical protein YMR152w - yeast (Saccharomyces cerevisiae) [NCBI NR] Uncharacterized protein YMR152W OS=Saccharomyces cerevisiae GN=YMR152W PE=1 SV=2 [Swiss-Prot] YIM1 Mitochondrial inner membrane protease [mips] Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [SGD] YIM1, Chr XIII from 563095-564192 [yeast_orfs2] Chr XIII from 563095-564192 [yeastorf3.fasta] (P28625) Hypothetical 41.6 kDa protein in IMP1-HLJ1 intergenic region (RF1095) [4932.FASTACCERV.txt] YIM1 SGDID:S0004760, Chr XIII from 563095-564192, Verified ORF [yeastflysequest.fasta] Mitochondrial inner membrane protease, similar to E. coli leader peptidase [Saccharomyces cerevisiae]gi\|2131840\|pir\|\|S50409 hypothetical protein YMR152w - yeast (Saccharomyces cerevisiae)gi\|45270728\|gb\|AAS56745.1\| YMR152W [Saccharomyces cerevisiae]gi\|7 [nrdb_11152004_Chlamydomonas] YIM1 SGDID:S000004760, Chr XIII from 563095-564192, Verified ORF, "Protein of unknown function; proposed to be involved in responding to DNA damaging agents" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YIM1 SGDID:S000004760, Chr XIII from 563095-564192, Verified ORF, "Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studi [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Protein of unknown function; proposed to be involved in responding to DNA damaging agents; Yim1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YMR152W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Hypothetical 41.6 kDa protein in IMP1-HLJ1 intergenic region (RF1095) [nr-271106-contam.fasta] YIM1 SGDID:S000004760, Chr XIII from 563095-564192, Verified ORF, "Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Protein YIM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YIM1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YIM1 SGDID:S000004760, Chr XIII from 563096-564193, Genome Release 64-1-1, Verified ORF, "Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" [yeast-030211-contam.fasta] YIM1 SGDID:S000004760, Chr XIII from 563096-564193, Genome Release 64-2-1, Verified ORF, "Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; may have a role in lipid metabolism, based on localization to lipid droplets; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta] TR4476\|c0_g1_i1\|g.3165 ORF TR4476\|c0_g1_i1\|g.3165 TR4476\|c0_g1_i1\|m.3165 type:complete len:366 (+) TR4476\|c0_g1_i1:510-1607(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR5905\|c0_g1_i1\|g.4172 ORF TR5905\|c0_g1_i1\|g.4172 TR5905\|c0_g1_i1\|m.4172 type:complete len:366 (+) TR5905\|c0_g1_i1:581-1678(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YMR152W SGDID:S000004760, Chr XIII from 563096-564193, Genome Release 64-1-1, Verified ORF, "Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_4319\|g.2522 ORF ID=asmbl_4319\|g.2522 ID=asmbl_4319\|m.2522 type:complete len:366 (+) ID=asmbl_4319:199-1296(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	365 amino acids
Gene Ontology:
Cellular Component:	lipid particle [IDA] cytoplasm [IDA] mitochondrion [IDA ]
Biological Process:	response to DNA damage stimulus [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDEIVTNKS VTYVNNTTPV TITSSELDLR SCYQDDEVVI EVHAAALNPI DFITHQLCNS  60
   61 YIFGKYPKTY SRDYSGVIIK AGKDVDNRWK VGDKVNGMYS HIYGERGTLT HYLILNPAKD 120
  121 VPITHMVEVP KDENDPYDDF VYAAAWPLTF GTAFSTLYDF KKDWTSDSKV LVIGASTSVS 180
  181 YAFVHIAKNY FNIGTVVGIC SKNSIERNKK LGYDYLVPYD EGSIVENVKK LKQSVLENDK 240
  241 FDMIFDSVGN HDFFPVIDQF LKPKAKNSFY VTIAGNNKAD YKNISWRDFV SLSSILKAIN 300
  301 PFKKYNWRFG HPYPPNNFIE VGNEMIKKGT YKPPIDSVYE FDQYKEAIDR LMSNRAKGKV 360
  361 VVKMK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YKU80	YIM1	1	Unpublished Fields Lab Data
View Screen	SPT21	YIM1	1	Unpublished Fields Lab Data
View Screen	RPC19	YIM1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YIM1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..131]	PSI-BLAST	68.0	Alcohol dehydrogenase
2	View Details	[132..151] [302..365]	PSI-BLAST	68.0	Alcohol dehydrogenase
3	View Details	[152..301]	PSI-BLAST	68.0	Alcohol dehydrogenase

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
oxidoreductase activity	2.38343643417648	bayes_pls_golite062009
binding	2.29520443217747	bayes_pls_golite062009
protein binding	1.35579823286173	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.30535930879645	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	1.22416351603098	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.22202241547461	bayes_pls_golite062009
chaperone binding	1.19079350615542	bayes_pls_golite062009
DNA binding	1.02274180655721	bayes_pls_golite062009
transcription regulator activity	0.955628854752953	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.905392379451071	bayes_pls_golite062009
nucleic acid binding	0.901776352952123	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	0.861534636764975	bayes_pls_golite062009
transporter activity	0.793769336118517	bayes_pls_golite062009
structural molecule activity	0.75267483298133	bayes_pls_golite062009
ligase activity	0.742884668104576	bayes_pls_golite062009
transmembrane transporter activity	0.635891484075352	bayes_pls_golite062009
alcohol dehydrogenase activity, zinc-dependent	0.558610278939188	bayes_pls_golite062009
substrate-specific transporter activity	0.555188550031886	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.51503848775098	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.410307505174239	bayes_pls_golite062009
transcription factor activity	0.368443846770004	bayes_pls_golite062009
hydrolase activity	0.358696225508357	bayes_pls_golite062009
ion transmembrane transporter activity	0.29802814097478	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.261132005311306	bayes_pls_golite062009
active transmembrane transporter activity	0.239024094835991	bayes_pls_golite062009
catalytic activity	0.217171374336363	bayes_pls_golite062009
cation transmembrane transporter activity	0.212092278332619	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.113340150368917	bayes_pls_golite062009
pyrophosphatase activity	0.0696058100530442	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0591634687578807	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0560606007580392	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2